Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A16

Gene

S100a16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro). Overexpression in 3T3-L1 preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (PubMed:21266506, PubMed:23526364).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi67 – 78Low affinity1 PublicationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A16
Alternative name(s):
Protein S100FImported
S100 calcium binding protein A16
Gene namesi
Name:S100a16Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915110 S100a16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004418021 – 124Protein S100-A16Add BLAST124

Proteomic databases

MaxQBiQ9D708
PaxDbiQ9D708
PRIDEiQ9D708

Expressioni

Tissue specificityi

Ubiquitous (PubMed:17030513). Widely distributed throughout the adult brain and predominantly expressed within specific astrocyte populations (PubMed:17030513). Expressed at high level in adipose tissues of obese animals (PubMed:21266506).2 Publications

Gene expression databases

BgeeiENSMUSG00000074457 Expressed in 273 organ(s), highest expression level in esophagus
ExpressionAtlasiQ9D708 baseline and differential

Interactioni

Subunit structurei

Homodimer (PubMed:17030513). Interacts with TP53 (PubMed:21266506).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096509

Structurei

3D structure databases

ProteinModelPortaliQ9D708
SMRiQ9D708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 37EF-hand 1; degenerate1 PublicationAdd BLAST15
Domaini54 – 89EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Domaini

S100A16 proteins, but not other S100 proteins, have only one functional Ca2+ binding site per monomer (PubMed:14684152, PubMed:17030513). Upon Ca2+ binding, undergoes conformational changes leading to the exposure of hydrophobic patches which could be implicated in the Ca2+-dependent nuclear export. Binds Zn2+ (PubMed:17030513). Ca2+ and Zn2+ do not bind to the same site (PubMed:17030513). Does not bind Cu2+ (PubMed:17030513).1 Publication1 Publication

Sequence similaritiesi

Belongs to the S-100 family.SAAS annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXNY Eukaryota
ENOG41115R5 LUCA
GeneTreeiENSGT00390000000920
HOGENOMiHOG000013071
HOVERGENiHBG001479
InParanoidiQ9D708
OMAiQQECQQE
OrthoDBiEOG091G0YU7
TreeFamiTF332727

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D708-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADCYTELEK AVVVLVENFY KYVSKHSLVK NKISKSSFRK MLQRELNHML
60 70 80 90 100
TDTGNRKAAD KLIQNLDANH DGRICFDEYW TMIGGITSPM ANLIRQQECQ
110 120
QESQQECQQE SQQESQQESQ QGSS
Length:124
Mass (Da):14,324
Last modified:June 1, 2001 - v1
Checksum:i644E9AC026C5AE7D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2Y6D3Z2Y6_MOUSE
Protein S100-A16
S100a16
72Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39R → Q in BAE35676 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY221962 mRNA Translation: AAP46153.1
AK009762 mRNA Translation: BAB26486.1
AK160178 mRNA Translation: BAE35676.1
AK160512 mRNA Translation: BAE35835.1
AK167006 mRNA Translation: BAE39183.1
AC160552 Genomic DNA No translation available.
CH466547 Genomic DNA Translation: EDL15119.1
CH466547 Genomic DNA Translation: EDL15120.1
CH466547 Genomic DNA Translation: EDL15121.1
CH466547 Genomic DNA Translation: EDL15122.1
BC020031 mRNA Translation: AAH20031.1
CCDSiCCDS17536.1
RefSeqiNP_080692.1, NM_026416.2
XP_006502011.1, XM_006501948.2
XP_006502012.1, XM_006501949.3
XP_006502013.1, XM_006501950.3
XP_006502014.1, XM_006501951.1
XP_006502015.1, XM_006501952.1
UniGeneiMm.331185

Genome annotation databases

EnsembliENSMUST00000098910; ENSMUSP00000096509; ENSMUSG00000074457
ENSMUST00000098911; ENSMUSP00000096510; ENSMUSG00000074457
ENSMUST00000107331; ENSMUSP00000102954; ENSMUSG00000074457
ENSMUST00000107333; ENSMUSP00000102956; ENSMUSG00000074457
ENSMUST00000107334; ENSMUSP00000102957; ENSMUSG00000074457
ENSMUST00000107335; ENSMUSP00000102958; ENSMUSG00000074457
GeneIDi67860
KEGGimmu:67860
UCSCiuc008qcw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY221962 mRNA Translation: AAP46153.1
AK009762 mRNA Translation: BAB26486.1
AK160178 mRNA Translation: BAE35676.1
AK160512 mRNA Translation: BAE35835.1
AK167006 mRNA Translation: BAE39183.1
AC160552 Genomic DNA No translation available.
CH466547 Genomic DNA Translation: EDL15119.1
CH466547 Genomic DNA Translation: EDL15120.1
CH466547 Genomic DNA Translation: EDL15121.1
CH466547 Genomic DNA Translation: EDL15122.1
BC020031 mRNA Translation: AAH20031.1
CCDSiCCDS17536.1
RefSeqiNP_080692.1, NM_026416.2
XP_006502011.1, XM_006501948.2
XP_006502012.1, XM_006501949.3
XP_006502013.1, XM_006501950.3
XP_006502014.1, XM_006501951.1
XP_006502015.1, XM_006501952.1
UniGeneiMm.331185

3D structure databases

ProteinModelPortaliQ9D708
SMRiQ9D708
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096509

Proteomic databases

MaxQBiQ9D708
PaxDbiQ9D708
PRIDEiQ9D708

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098910; ENSMUSP00000096509; ENSMUSG00000074457
ENSMUST00000098911; ENSMUSP00000096510; ENSMUSG00000074457
ENSMUST00000107331; ENSMUSP00000102954; ENSMUSG00000074457
ENSMUST00000107333; ENSMUSP00000102956; ENSMUSG00000074457
ENSMUST00000107334; ENSMUSP00000102957; ENSMUSG00000074457
ENSMUST00000107335; ENSMUSP00000102958; ENSMUSG00000074457
GeneIDi67860
KEGGimmu:67860
UCSCiuc008qcw.1 mouse

Organism-specific databases

CTDi140576
MGIiMGI:1915110 S100a16

Phylogenomic databases

eggNOGiENOG410IXNY Eukaryota
ENOG41115R5 LUCA
GeneTreeiENSGT00390000000920
HOGENOMiHOG000013071
HOVERGENiHBG001479
InParanoidiQ9D708
OMAiQQECQQE
OrthoDBiEOG091G0YU7
TreeFamiTF332727

Miscellaneous databases

PROiPR:Q9D708
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074457 Expressed in 273 organ(s), highest expression level in esophagus
ExpressionAtlasiQ9D708 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10AG_MOUSE
AccessioniPrimary (citable) accession number: Q9D708
Secondary accession number(s): Q3TVE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again