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Protein

RNA polymerase II-associated protein 3

Gene

Rpap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II-associated protein 3
Gene namesi
Name:Rpap3
Synonyms:D15Ertd682e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1277218 Rpap3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003027952 – 660RNA polymerase II-associated protein 3Add BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei117PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei476PhosphoserineBy similarity1
Cross-linki493Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D706
MaxQBiQ9D706
PaxDbiQ9D706
PeptideAtlasiQ9D706
PRIDEiQ9D706

PTM databases

iPTMnetiQ9D706
PhosphoSitePlusiQ9D706

Expressioni

Gene expression databases

BgeeiENSMUSG00000022466
CleanExiMM_RPAP3
GenevisibleiQ9D706 MM

Interactioni

Subunit structurei

Tightly associated with the RNA polymerase II complex. Component of the R2TP complex composed at least of PIHD1, RUVBL1, RUVBL2 and RPAP3. Interacts with PIH1D1.By similarity

Protein-protein interaction databases

IntActiQ9D706, 1 interactor
MINTiQ9D706
STRINGi10090.ENSMUSP00000023104

Structurei

3D structure databases

ProteinModelPortaliQ9D706
SMRiQ9D706
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 41TPR 1Add BLAST34
Repeati134 – 167TPR 2Add BLAST34
Repeati169 – 201TPR 3Add BLAST33
Repeati202 – 235TPR 4Add BLAST34
Repeati284 – 317TPR 5Add BLAST34
Repeati319 – 351TPR 6Add BLAST33
Repeati352 – 385TPR 7Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 71Poly-Lys9

Sequence similaritiesi

Belongs to the RPAP3 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4648 Eukaryota
ENOG4111KG3 LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000154181
HOVERGENiHBG059892
InParanoidiQ9D706
OMAiSYSKAFA
OrthoDBiEOG091G0IS5
PhylomeDBiQ9D706
TreeFamiTF106243

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR025986 RPAP3-like_C
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13877 RPAP3_C, 1 hit
PF00515 TPR_1, 2 hits
PF13176 TPR_7, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSASKAVEL QLQVKHNAEE LQDFMRDLEH WEKDMKEKDL ELRRQGGVAE
60 70 80 90 100
ENLPPIRNGN FRKKKKKGKA KESSRKTKEE NTKNRIKSYD YDAWAKLDVD
110 120 130 140 150
RILDELDKED STHDSLSQES ESDEDGIRVD SQKALVLKEK GNKYFKQGKY
160 170 180 190 200
DEAIECYTKG MDADPYNPVL PTNRASAYFR LKKFAVAESD CNLAIALSRT
210 220 230 240 250
YTKAYARRGA ARFALQKLED ARKDYEKVLE LEPDNFEATN ELRKINQALT
260 270 280 290 300
SKENSGPGAA AAAESKPAAG ESKPTGGQQG RQKAIAEKDL GNGFFKEGKY
310 320 330 340 350
EQAIECYTRG IAADRTNALL PANRAMAYLK IQRYEEAERD CTQAIVLDGS
360 370 380 390 400
YSKAFARRGT ARTFLGKINE AKQDFETVLL LEPGNKQAAT ELSRIKKELI
410 420 430 440 450
EKGHWDDVFL DSTQRHHVVK AVDNPPRGSP KALKKVFIEE TGNLIETVDA
460 470 480 490 500
PDSSATVPES DRATAAVGTG TKKNPSEGVS LPAGDRPRAK VLKIEAVSDT
510 520 530 540 550
SAPQAQVGVK QDARQPGSEK ASVRAEQMPG QLAAAGLPPV PANSFQLESD
560 570 580 590 600
FRQLRSSPEM LYQYVKNIEP SLYPKLFQKN LDPDVFNQII KILHDFYIER
610 620 630 640 650
EKPALIFEVL ERLSQLRRFD MAVMFMSGPE RKLTNVLFNH LEKSDLKEDS
660
VEELKKRYGG
Length:660
Mass (Da):74,096
Last modified:June 1, 2001 - v1
Checksum:i0D04AAD9F1D479CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009765 mRNA Translation: BAB26489.1
AK169097 mRNA Translation: BAE40880.1
BC004046 mRNA Translation: AAH04046.1
CCDSiCCDS27782.1
RefSeqiNP_082279.1, NM_028003.2
UniGeneiMm.12255

Genome annotation databases

EnsembliENSMUST00000023104; ENSMUSP00000023104; ENSMUSG00000022466
GeneIDi71919
KEGGimmu:71919
UCSCiuc007xkv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRPAP3_MOUSE
AccessioniPrimary (citable) accession number: Q9D706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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