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Protein

Interleukin-36 beta

Gene

Il36b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4+ T-cells and splenocytes.By similarity2 Publications

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-9014826 Interleukin-36 pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-36 beta
Alternative name(s):
Interleukin-1 family member 8
Short name:
IL-1F8
Gene namesi
Name:Il36b
Synonyms:Fil1e, Il1f8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916927 Il1f8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00004305481 – 301 PublicationAdd BLAST30
ChainiPRO_000015364731 – 183Interleukin-36 betaAdd BLAST153

Post-translational modificationi

N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).1 Publication

Proteomic databases

PaxDbiQ9D6Z6
PRIDEiQ9D6Z6

PTM databases

PhosphoSitePlusiQ9D6Z6

Expressioni

Gene expression databases

BgeeiENSMUSG00000026985 Expressed in 23 organ(s), highest expression level in uterine cervix
CleanExiMM_IL1F8
ExpressionAtlasiQ9D6Z6 baseline and differential
GenevisibleiQ9D6Z6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028363

Structurei

3D structure databases

ProteinModelPortaliQ9D6Z6
SMRiQ9D6Z6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JCFD Eukaryota
ENOG41118F0 LUCA
GeneTreeiENSGT00900000141014
HOVERGENiHBG052100
InParanoidiQ9D6Z6
KOiK05486
OMAiERGITNN
OrthoDBiEOG091G0T4K
PhylomeDBiQ9D6Z6
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR027172 IL-36_beta
IPR008996 IL1/FGF
PANTHERiPTHR10078:SF24 PTHR10078:SF24, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D6Z6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAFPPQSCV HVLPPKSIQM WEPNHNTMHG SSQSPRNYRV HDSQQMVWVL
60 70 80 90 100
TGNTLTAVPA SNNVKPVILS LIACRDTEFQ DVKKGNLVFL GIKNRNLCFC
110 120 130 140 150
CVEMEGKPTL QLKEVDIMNL YKERKAQKAF LFYHGIEGST SVFQSVLYPG
160 170 180
WFIATSSIER QTIILTHQRG KLVNTNFYIE SEK
Length:183
Mass (Da):20,878
Last modified:June 1, 2001 - v1
Checksum:iA3ACE339FB96F02F
GO

Sequence cautioni

The sequence AAL67152 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY071842 mRNA Translation: AAL67152.1 Different initiation.
AK009787 mRNA Translation: BAB26505.1
CCDSiCCDS38063.1
RefSeqiNP_081439.1, NM_027163.4
UniGeneiMm.45901

Genome annotation databases

EnsembliENSMUST00000028363; ENSMUSP00000028363; ENSMUSG00000026985
GeneIDi69677
KEGGimmu:69677
UCSCiuc008ion.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY071842 mRNA Translation: AAL67152.1 Different initiation.
AK009787 mRNA Translation: BAB26505.1
CCDSiCCDS38063.1
RefSeqiNP_081439.1, NM_027163.4
UniGeneiMm.45901

3D structure databases

ProteinModelPortaliQ9D6Z6
SMRiQ9D6Z6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028363

PTM databases

PhosphoSitePlusiQ9D6Z6

Proteomic databases

PaxDbiQ9D6Z6
PRIDEiQ9D6Z6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028363; ENSMUSP00000028363; ENSMUSG00000026985
GeneIDi69677
KEGGimmu:69677
UCSCiuc008ion.1 mouse

Organism-specific databases

CTDi69677
MGIiMGI:1916927 Il1f8

Phylogenomic databases

eggNOGiENOG410JCFD Eukaryota
ENOG41118F0 LUCA
GeneTreeiENSGT00900000141014
HOVERGENiHBG052100
InParanoidiQ9D6Z6
KOiK05486
OMAiERGITNN
OrthoDBiEOG091G0T4K
PhylomeDBiQ9D6Z6
TreeFamiTF300203

Enzyme and pathway databases

ReactomeiR-MMU-9014826 Interleukin-36 pathway

Miscellaneous databases

PROiPR:Q9D6Z6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026985 Expressed in 23 organ(s), highest expression level in uterine cervix
CleanExiMM_IL1F8
ExpressionAtlasiQ9D6Z6 baseline and differential
GenevisibleiQ9D6Z6 MM

Family and domain databases

InterProiView protein in InterPro
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR027172 IL-36_beta
IPR008996 IL1/FGF
PANTHERiPTHR10078:SF24 PTHR10078:SF24, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL36B_MOUSE
AccessioniPrimary (citable) accession number: Q9D6Z6
Secondary accession number(s): Q8R461
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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