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Protein

Nucleolar protein 56

Gene

Nop56

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 56
Alternative name(s):
Nucleolar protein 5A
Gene namesi
Name:Nop56
Synonyms:Nol5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914384 Nop56

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190271 – 580Nucleolar protein 56Add BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki230Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei314PhosphoserineBy similarity1
Modified residuei359Omega-N-methylarginineBy similarity1
Modified residuei465PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei467PhosphothreonineCombined sources1
Modified residuei513PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1
Cross-linki531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei536PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei545PhosphothreonineCombined sources1
Modified residuei546PhosphothreonineCombined sources1
Modified residuei552N6-acetyllysineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei565N6-acetyllysineCombined sources1
Modified residuei567PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D6Z1
MaxQBiQ9D6Z1
PaxDbiQ9D6Z1
PeptideAtlasiQ9D6Z1
PRIDEiQ9D6Z1

PTM databases

iPTMnetiQ9D6Z1
PhosphoSitePlusiQ9D6Z1

Expressioni

Tissue specificityi

Widely expressed, with highest levels in the central nervous system (CNS), including cerebral cortex and cerebellum, and spleen. In the CNS, expressed in Purkinje cells of the cerebellum, as well as in motor neurons of the hypoglossal nucleus and in the spinal cord anterior horn (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000027405 Expressed in 40 organ(s), highest expression level in embryonic stem cell
CleanExiMM_NOL5A
ExpressionAtlasiQ9D6Z1 baseline and differential
GenevisibleiQ9D6Z1 MM

Interactioni

Subunit structurei

Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts NOP1 and NOP58. Interacts with NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP56 with NUFIP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211966, 7 interactors
CORUMiQ9D6Z1
IntActiQ9D6Z1, 12 interactors
MINTiQ9D6Z1
STRINGi10090.ENSMUSP00000099487

Structurei

3D structure databases

ProteinModelPortaliQ9D6Z1
SMRiQ9D6Z1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 410NopPROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi438 – 576Lys-richAdd BLAST139

Sequence similaritiesi

Belongs to the NOP5/NOP56 family.Curated

Phylogenomic databases

eggNOGiKOG2572 Eukaryota
COG1498 LUCA
GeneTreeiENSGT00550000075068
HOGENOMiHOG000196309
InParanoidiQ9D6Z1
KOiK14564
OMAiLKFYESG
OrthoDBiEOG091G06JZ
PhylomeDBiQ9D6Z1
TreeFamiTF105713

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR029012 Helix_hairpin_bin_sf
IPR012974 NOP5_N
IPR002687 Nop_dom
IPR036070 Nop_dom_sf
IPR012976 NOSIC
PfamiView protein in Pfam
PF01798 Nop, 1 hit
PF08156 NOP5NT, 1 hit
SMARTiView protein in SMART
SM00931 NOSIC, 1 hit
SUPFAMiSSF89124 SSF89124, 1 hit
PROSITEiView protein in PROSITE
PS51358 NOP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9D6Z1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLLHVLFEH AVGYALLALK EVEEISLLLP QVEECVLNLG KFHNVVRLVA
60 70 80 90 100
FCPFSSSQVA LENANAVSEG VVHEDLRLLL ETYLPSKKKK VLLGVGDPKI
110 120 130 140 150
GAAIQEELGY NCQTGGVIAE ILRGVRLHFH NLVKGLTDLS ACKAQLGLGH
160 170 180 190 200
SYSRAKVKFN VNRVDNMIIQ SISLLDQLDK DINTFSMRVR EWYGYHFPEL
210 220 230 240 250
VKIVNDNATY CRLAQFIGNR RELNEEKLEK LEEITMDGAK AKAILDASRS
260 270 280 290 300
SMGMDISAID LINIESFSSR VVSLSEYRQS LHTYLRSKMS QVAPSLSALI
310 320 330 340 350
GEAVGARLIA HAGSLTNLAK YPASTVQILG AEKALFRALK TRGNTPKYGL
360 370 380 390 400
IFHSTFIGRA AAKNKGRISR YLANKCSIAS RIDCFSEVPT SVFGEKLREQ
410 420 430 440 450
VEERLSFYET GEIPRKNLDV MKEAVVQAEE AAAEITRKLE KQEKKRLKKE
460 470 480 490 500
KKRLAALALA SSENSSTPEE CEEVNEKSKK KKKLKPQENG MEDPPVSLPK
510 520 530 540 550
SKKKKAPKEE LASDLEEMAT SSAKRKKSSP KEEVASEPEE AASPTTPKKK
560 570 580
RKFSEEPEVA ANFTKSSTKK KKKSQKAQED
Length:580
Mass (Da):64,464
Last modified:May 16, 2003 - v2
Checksum:i60AA1D43E349ADD7
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2APD7A2APD7_MOUSE
Nucleolar protein 56
Nop56
296Annotation score:
F6U250F6U250_MOUSE
Nucleolar protein 56
Nop56
135Annotation score:
F6V095F6V095_MOUSE
Nucleolar protein 56
Nop56
173Annotation score:
F7CHQ7F7CHQ7_MOUSE
Nucleolar protein 56
Nop56
222Annotation score:
E0CXZ0E0CXZ0_MOUSE
Nucleolar protein 56
Nop56
261Annotation score:
F6USW7F6USW7_MOUSE
Nucleolar protein 56
Nop56
125Annotation score:
F7CHP9F7CHP9_MOUSE
Nucleolar protein 56
Nop56
173Annotation score:
F6TLG3F6TLG3_MOUSE
Nucleolar protein 56
Nop56
18Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170Q → K in BAC37015 (PubMed:16141072).Curated1
Sequence conflicti182I → V in BAB27647 (PubMed:16141072).Curated1
Sequence conflicti436T → A in AAH21355 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009799 mRNA Translation: BAB26511.1
AK011481 mRNA Translation: BAB27647.3
AK077795 mRNA Translation: BAC37015.1
AK150258 mRNA Translation: BAE29417.1
BC002231 mRNA Translation: AAH02231.1
BC021355 mRNA Translation: AAH21355.1
CCDSiCCDS16737.1
RefSeqiNP_077155.2, NM_024193.2
UniGeneiMm.29363

Genome annotation databases

EnsembliENSMUST00000103198; ENSMUSP00000099487; ENSMUSG00000027405
GeneIDi67134
KEGGimmu:67134
UCSCiuc008mil.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009799 mRNA Translation: BAB26511.1
AK011481 mRNA Translation: BAB27647.3
AK077795 mRNA Translation: BAC37015.1
AK150258 mRNA Translation: BAE29417.1
BC002231 mRNA Translation: AAH02231.1
BC021355 mRNA Translation: AAH21355.1
CCDSiCCDS16737.1
RefSeqiNP_077155.2, NM_024193.2
UniGeneiMm.29363

3D structure databases

ProteinModelPortaliQ9D6Z1
SMRiQ9D6Z1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211966, 7 interactors
CORUMiQ9D6Z1
IntActiQ9D6Z1, 12 interactors
MINTiQ9D6Z1
STRINGi10090.ENSMUSP00000099487

PTM databases

iPTMnetiQ9D6Z1
PhosphoSitePlusiQ9D6Z1

Proteomic databases

EPDiQ9D6Z1
MaxQBiQ9D6Z1
PaxDbiQ9D6Z1
PeptideAtlasiQ9D6Z1
PRIDEiQ9D6Z1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103198; ENSMUSP00000099487; ENSMUSG00000027405
GeneIDi67134
KEGGimmu:67134
UCSCiuc008mil.1 mouse

Organism-specific databases

CTDi10528
MGIiMGI:1914384 Nop56

Phylogenomic databases

eggNOGiKOG2572 Eukaryota
COG1498 LUCA
GeneTreeiENSGT00550000075068
HOGENOMiHOG000196309
InParanoidiQ9D6Z1
KOiK14564
OMAiLKFYESG
OrthoDBiEOG091G06JZ
PhylomeDBiQ9D6Z1
TreeFamiTF105713

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiNop56 mouse
PROiPR:Q9D6Z1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027405 Expressed in 40 organ(s), highest expression level in embryonic stem cell
CleanExiMM_NOL5A
ExpressionAtlasiQ9D6Z1 baseline and differential
GenevisibleiQ9D6Z1 MM

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR029012 Helix_hairpin_bin_sf
IPR012974 NOP5_N
IPR002687 Nop_dom
IPR036070 Nop_dom_sf
IPR012976 NOSIC
PfamiView protein in Pfam
PF01798 Nop, 1 hit
PF08156 NOP5NT, 1 hit
SMARTiView protein in SMART
SM00931 NOSIC, 1 hit
SUPFAMiSSF89124 SSF89124, 1 hit
PROSITEiView protein in PROSITE
PS51358 NOP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOP56_MOUSE
AccessioniPrimary (citable) accession number: Q9D6Z1
Secondary accession number(s): Q3UD45
, Q8BVL1, Q8VDT2, Q99LT8, Q9CT15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 16, 2003
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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