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Protein

Coiled-coil domain-containing protein 3

Gene

Ccdc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 3
Alternative name(s):
Fat/vessel-derived secretory protein
Short name:
Favine1 Publication
Gene namesi
Name:Ccdc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921436 Ccdc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice exhibit a lean phenotype with reduced fat mass and smaller adipocyte size compared to wild type mice. Adipose tissue exhibit decreased levels of lipogenic genes, such as fatty-acid synthase (FASN), acetyl-CoA carboxylase (ACACA) and diacylglycerol O-acyltransferase-2 (DGAT2). Mice exhibit strongly inhibited age-related hepatic steatosis and decreased number of inflammatory cells in epididymal adipose tissue.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000002086322 – 273Coiled-coil domain-containing protein 3Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D6Y1
PaxDbiQ9D6Y1
PRIDEiQ9D6Y1

PTM databases

iPTMnetiQ9D6Y1
PhosphoSitePlusiQ9D6Y1

Expressioni

Tissue specificityi

Expressed in aorta and adipose tissue. Enriched in mature adipocytes. Over-expressed in adipose tissue from either hormonally-induced or nutritionally-regulated obese mice models.1 Publication

Gene expression databases

BgeeiENSMUSG00000026676 Expressed in 195 organ(s), highest expression level in aorta
CleanExiMM_CCDC3
GenevisibleiQ9D6Y1 MM

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027988

Structurei

3D structure databases

ProteinModelPortaliQ9D6Y1
SMRiQ9D6Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili188 – 250Sequence analysisAdd BLAST63

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IICP Eukaryota
ENOG410Y2JM LUCA
GeneTreeiENSGT00390000014429
HOGENOMiHOG000231502
HOVERGENiHBG050821
InParanoidiQ9D6Y1
OMAiCQLPSDW
OrthoDBiEOG091G0FRS
PhylomeDBiQ9D6Y1
TreeFamiTF331410

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D6Y1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLPLLLAAL CLAASPAPAR ACQLPSEWRP LSEGCRAELA ETIVYAKVLA
60 70 80 90 100
LHPEVPGLYN YLPWQYQAGE GGLFYSAEVE MLCDQAWGSM LEVPAGSRLN
110 120 130 140 150
LTGLGYFSCH SHTVVQDYSY FFFVRMDENY NLLPHGVNFQ DAIFPDTQEN
160 170 180 190 200
RRMFSSLFQF ANCSQGQQLT TFSSDWEVQE DNRLMCSSVQ KALFEEEDHV
210 220 230 240 250
KKLQQKVATL EKRNRQLRER VKKVKRSLRQ ARKNSRHLEL VNQKLNEKLG
260 270
ASSAQQHINA LGREPVRAPY LHG
Length:273
Mass (Da):31,093
Last modified:June 1, 2001 - v1
Checksum:iC6F94A2CAD606E79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009833 mRNA Translation: BAB26531.1
BC058616 mRNA Translation: AAH58616.1
CCDSiCCDS15664.1
RefSeqiNP_083080.1, NM_028804.1
UniGeneiMm.274715

Genome annotation databases

EnsembliENSMUST00000027988; ENSMUSP00000027988; ENSMUSG00000026676
GeneIDi74186
KEGGimmu:74186
UCSCiuc008ifo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009833 mRNA Translation: BAB26531.1
BC058616 mRNA Translation: AAH58616.1
CCDSiCCDS15664.1
RefSeqiNP_083080.1, NM_028804.1
UniGeneiMm.274715

3D structure databases

ProteinModelPortaliQ9D6Y1
SMRiQ9D6Y1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027988

PTM databases

iPTMnetiQ9D6Y1
PhosphoSitePlusiQ9D6Y1

Proteomic databases

MaxQBiQ9D6Y1
PaxDbiQ9D6Y1
PRIDEiQ9D6Y1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027988; ENSMUSP00000027988; ENSMUSG00000026676
GeneIDi74186
KEGGimmu:74186
UCSCiuc008ifo.1 mouse

Organism-specific databases

CTDi83643
MGIiMGI:1921436 Ccdc3

Phylogenomic databases

eggNOGiENOG410IICP Eukaryota
ENOG410Y2JM LUCA
GeneTreeiENSGT00390000014429
HOGENOMiHOG000231502
HOVERGENiHBG050821
InParanoidiQ9D6Y1
OMAiCQLPSDW
OrthoDBiEOG091G0FRS
PhylomeDBiQ9D6Y1
TreeFamiTF331410

Miscellaneous databases

PROiPR:Q9D6Y1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026676 Expressed in 195 organ(s), highest expression level in aorta
CleanExiMM_CCDC3
GenevisibleiQ9D6Y1 MM

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCDC3_MOUSE
AccessioniPrimary (citable) accession number: Q9D6Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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