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Protein

BLOC-1-related complex subunit 6

Gene

Borcs6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BLOC-1-related complex subunit 6Curated
Gene namesi
Name:Borcs6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919173 Borcs6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939611 – 360BLOC-1-related complex subunit 6Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphothreonineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei201PhosphothreonineCombined sources1
Modified residuei204PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D6W8
MaxQBiQ9D6W8
PaxDbiQ9D6W8
PeptideAtlasiQ9D6W8
PRIDEiQ9D6W8

PTM databases

iPTMnetiQ9D6W8
PhosphoSitePlusiQ9D6W8

Expressioni

Gene expression databases

BgeeiENSMUSG00000045176
GenevisibleiQ9D6W8 MM

Interactioni

Subunit structurei

Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN.By similarity

Protein-protein interaction databases

IntActiQ9D6W8, 3 interactors
MINTiQ9D6W8
STRINGi10090.ENSMUSP00000059143

Structurei

3D structure databases

ProteinModelPortaliQ9D6W8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi236 – 261Pro-richAdd BLAST26

Sequence similaritiesi

Belongs to the BORCS6 family.Curated

Phylogenomic databases

eggNOGiKOG4514 Eukaryota
ENOG4111TSS LUCA
GeneTreeiENSGT00490000043453
HOGENOMiHOG000111935
HOVERGENiHBG060339
InParanoidiQ9D6W8
KOiK20820
OMAiGGANRHP
OrthoDBiEOG091G0NP7
PhylomeDBiQ9D6W8

Family and domain databases

InterProiView protein in InterPro
IPR019314 BORCS6
PANTHERiPTHR13440 PTHR13440, 1 hit
PfamiView protein in Pfam
PF10157 BORCS6, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D6W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAQGRLGP EPELSVGAEH QAATFSGRPS RTPSKPPSVR TLSGEEEAES
60 70 80 90 100
VGVSSRHPRA SPKTWSGSIA HGPELDTWED KPSSRATPSG ARGRRGVPGS
110 120 130 140 150
EHAPPPSSWY PEPEPSEDQP SALRVCRRGS PGGVEMNVEL PQQEGDDDDD
160 170 180 190 200
EDEEAAAGRA GRSFPSRLQD SRSLDGLSGA CGGGGSSSSG ETGAGGGRRA
210 220 230 240 250
TISSPLELEG TVSRHGDLTH FVANNLQLKI RLSGAPPPVP PASVRPCLTP
260 270 280 290 300
APTPTIPPID PDVLRDLERL SRELGGRVDR LLRGLGGAVQ ELTALSVGCI
310 320 330 340 350
QTYRDAVDSL GEAVDMSIKG MYTLLARCEE LERALQPVQG LARQVRDIRR
360
TLEVLEALCK
Length:360
Mass (Da):38,011
Last modified:June 1, 2001 - v1
Checksum:iC74C6ED72FF92EB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285L → V in BAE41427 (PubMed:16141072).Curated1
Sequence conflicti300I → T in BAE41427 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK169875 mRNA Translation: BAE41427.1
AK009886 mRNA Translation: BAB26563.1
AK151629 mRNA Translation: BAE30563.1
AL645902 Genomic DNA No translation available.
CCDSiCCDS36190.1
RefSeqiNP_082281.2, NM_028005.3
UniGeneiMm.340257

Genome annotation databases

EnsembliENSMUST00000051888; ENSMUSP00000059143; ENSMUSG00000045176
GeneIDi71923
KEGGimmu:71923
UCSCiuc007jpb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBORC6_MOUSE
AccessioniPrimary (citable) accession number: Q9D6W8
Secondary accession number(s): Q3TE21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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