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Protein

Polyadenylate-binding protein-interacting protein 2

Gene

Paip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein-interacting protein 2
Short name:
PABP-interacting protein 2
Short name:
PAIP-2
Short name:
Poly(A)-binding protein-interacting protein 2
Gene namesi
Name:Paip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1915119 Paip2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581801 – 124Polyadenylate-binding protein-interacting protein 2Add BLAST124

Post-translational modificationi

Ubiquitinated, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9D6V8
MaxQBiQ9D6V8
PaxDbiQ9D6V8
PeptideAtlasiQ9D6V8
PRIDEiQ9D6V8

PTM databases

PhosphoSitePlusiQ9D6V8

Expressioni

Tissue specificityi

Expressed at high levels in testis with expression also detected in heart, brain, lung, liver, kidney, pancreas and small intestine (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000037058 Expressed in 287 organ(s), highest expression level in membranous labyrinth
GenevisibleiQ9D6V8 MM

Interactioni

Subunit structurei

Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036021

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 75PABPC1-interacting motif-1 (PAM1)By similarityAdd BLAST54
Regioni105 – 120PABPC1-interacting motif-2 (PAM2)By similarityAdd BLAST16

Domaini

Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.By similarity

Sequence similaritiesi

Belongs to the PAIP2 family.Curated

Phylogenomic databases

eggNOGiENOG410IW9Y Eukaryota
ENOG410Y214 LUCA
GeneTreeiENSGT00390000017284
HOGENOMiHOG000008098
HOVERGENiHBG053493
InParanoidiQ9D6V8
OMAiWEEEFME
OrthoDBiEOG091G1372
PhylomeDBiQ9D6V8
TreeFamiTF326855

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
PfamiView protein in Pfam
PF07145 PAM2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D6V8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDPSRSSTS PSIINDDVII NGHSHEEDNP FAEYMWMENE EEFNRQIEEE
60 70 80 90 100
LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS
110 120
SLEDLVVKSN LNPNAKEFVP GVKY
Length:124
Mass (Da):14,700
Last modified:June 1, 2001 - v1
Checksum:i0D1241C3F89C85D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30P → T in BAB24053 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005462 mRNA Translation: BAB24053.1
AK009909 mRNA Translation: BAB26578.1
AK146327 mRNA Translation: BAE27082.1
AK150957 mRNA Translation: BAE29989.1
AK169207 mRNA Translation: BAE40979.1
AK169411 mRNA Translation: BAE41157.1
BC010190 mRNA Translation: AAH10190.1
CCDSiCCDS29143.1
RefSeqiNP_080696.1, NM_026420.2
XP_011245289.1, XM_011246987.2
XP_011245290.1, XM_011246988.2
XP_011245291.1, XM_011246989.1
XP_011245292.1, XM_011246990.2
XP_017173461.1, XM_017317972.1
XP_017173462.1, XM_017317973.1
UniGeneiMm.126534

Genome annotation databases

EnsembliENSMUST00000041314; ENSMUSP00000036021; ENSMUSG00000037058
ENSMUST00000115734; ENSMUSP00000111399; ENSMUSG00000037058
ENSMUST00000115735; ENSMUSP00000111400; ENSMUSG00000037058
ENSMUST00000115736; ENSMUSP00000111401; ENSMUSG00000037058
ENSMUST00000115737; ENSMUSP00000111402; ENSMUSG00000037058
GeneIDi67869
KEGGimmu:67869
UCSCiuc008emj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005462 mRNA Translation: BAB24053.1
AK009909 mRNA Translation: BAB26578.1
AK146327 mRNA Translation: BAE27082.1
AK150957 mRNA Translation: BAE29989.1
AK169207 mRNA Translation: BAE40979.1
AK169411 mRNA Translation: BAE41157.1
BC010190 mRNA Translation: AAH10190.1
CCDSiCCDS29143.1
RefSeqiNP_080696.1, NM_026420.2
XP_011245289.1, XM_011246987.2
XP_011245290.1, XM_011246988.2
XP_011245291.1, XM_011246989.1
XP_011245292.1, XM_011246990.2
XP_017173461.1, XM_017317972.1
XP_017173462.1, XM_017317973.1
UniGeneiMm.126534

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036021

PTM databases

PhosphoSitePlusiQ9D6V8

Proteomic databases

EPDiQ9D6V8
MaxQBiQ9D6V8
PaxDbiQ9D6V8
PeptideAtlasiQ9D6V8
PRIDEiQ9D6V8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041314; ENSMUSP00000036021; ENSMUSG00000037058
ENSMUST00000115734; ENSMUSP00000111399; ENSMUSG00000037058
ENSMUST00000115735; ENSMUSP00000111400; ENSMUSG00000037058
ENSMUST00000115736; ENSMUSP00000111401; ENSMUSG00000037058
ENSMUST00000115737; ENSMUSP00000111402; ENSMUSG00000037058
GeneIDi67869
KEGGimmu:67869
UCSCiuc008emj.1 mouse

Organism-specific databases

CTDi51247
MGIiMGI:1915119 Paip2

Phylogenomic databases

eggNOGiENOG410IW9Y Eukaryota
ENOG410Y214 LUCA
GeneTreeiENSGT00390000017284
HOGENOMiHOG000008098
HOVERGENiHBG053493
InParanoidiQ9D6V8
OMAiWEEEFME
OrthoDBiEOG091G1372
PhylomeDBiQ9D6V8
TreeFamiTF326855

Miscellaneous databases

ChiTaRSiPaip2 mouse
PROiPR:Q9D6V8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037058 Expressed in 287 organ(s), highest expression level in membranous labyrinth
GenevisibleiQ9D6V8 MM

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
PfamiView protein in Pfam
PF07145 PAM2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAIP2_MOUSE
AccessioniPrimary (citable) accession number: Q9D6V8
Secondary accession number(s): Q3UBH5, Q9DAW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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