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Protein

Tubulin epsilon chain

Gene

Tube1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi148 – 154GTPSequence analysis7

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: GO_Central
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin epsilon chain
Alternative name(s):
Epsilon-tubulin
Gene namesi
Name:Tube1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919174 Tube1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333521 – 475Tubulin epsilon chainAdd BLAST475

Proteomic databases

EPDiQ9D6T1
MaxQBiQ9D6T1
PaxDbiQ9D6T1
PeptideAtlasiQ9D6T1
PRIDEiQ9D6T1

PTM databases

PhosphoSitePlusiQ9D6T1

Expressioni

Gene expression databases

BgeeiENSMUSG00000019845 Expressed in 184 organ(s), highest expression level in secondary oocyte
CleanExiMM_TUBE1
ExpressionAtlasiQ9D6T1 baseline and differential
GenevisibleiQ9D6T1 MM

Interactioni

Protein-protein interaction databases

BioGridi215035, 36 interactors
IntActiQ9D6T1, 34 interactors
STRINGi10090.ENSMUSP00000019991

Structurei

3D structure databases

ProteinModelPortaliQ9D6T1
SMRiQ9D6T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00930000150956
HOGENOMiHOG000165713
HOVERGENiHBG098062
InParanoidiQ9D6T1
KOiK10391
OMAiYNQLDAT
OrthoDBiEOG091G06O0
PhylomeDBiQ9D6T1
TreeFamiTF330882

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR004057 Epsilon_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF13 PTHR11588:SF13, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01519 EPSLNTUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D6T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQSVVVQVG QCGNQIGCCF WDLALREHAA VNQKGIYDDA ISSFFRNVDT
60 70 80 90 100
RAVGDGGSIS KGRISSLKAR AVLIDMEEGV VNEILQGPLR DVFDSKQLIT
110 120 130 140 150
DISGSGNNWA VGHKVFGCLY REQILEKLRK SAEQCDCLQC FFIIHSMGGG
160 170 180 190 200
TGSGLGTFLL KVLEDEFPEV YRFVTAVYPS SEDDVITSPY NSMLAMKELN
210 220 230 240 250
EHADCVLPID NQSLFDIISK IDLVVNSGKL GSAVKPKSLI TSNMGAVKKH
260 270 280 290 300
HKKPFDAMNN IVANLLLSLT SSARFEGSLN MDLNEISMNL VPFPKLHYLV
310 320 330 340 350
SSLTPLYTLA DVNIPPRRLD QMFSDAFSKD HQLIQADPRH SLYLACALIV
360 370 380 390 400
RGNVQISDLR RNIERLKPAL QFVSWNQEGW KTSLCSVPPV GHSHSLLALA
410 420 430 440 450
NNTCVKPTFM ELRERFTRLY KKKAHLHHYL QVDGMEESTF TEAVSSLSAL
460 470
IQEYSDLDAT KSLPVPDVPR LSVAL
Length:475
Mass (Da):52,652
Last modified:June 1, 2001 - v1
Checksum:iD5CA050DD7DE0DD1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SU34A0A1L1SU34_MOUSE
Epsilon-tubulin 1, isoform CRA_b
Tube1 mCG_113294
216Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010005 mRNA Translation: BAB26636.1
AK148039 mRNA Translation: BAE28305.1
BC062179 mRNA Translation: AAH62179.1
CCDSiCCDS23787.1
RefSeqiNP_082282.1, NM_028006.2
UniGeneiMm.297956

Genome annotation databases

EnsembliENSMUST00000019991; ENSMUSP00000019991; ENSMUSG00000019845
GeneIDi71924
KEGGimmu:71924
UCSCiuc007evu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010005 mRNA Translation: BAB26636.1
AK148039 mRNA Translation: BAE28305.1
BC062179 mRNA Translation: AAH62179.1
CCDSiCCDS23787.1
RefSeqiNP_082282.1, NM_028006.2
UniGeneiMm.297956

3D structure databases

ProteinModelPortaliQ9D6T1
SMRiQ9D6T1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215035, 36 interactors
IntActiQ9D6T1, 34 interactors
STRINGi10090.ENSMUSP00000019991

PTM databases

PhosphoSitePlusiQ9D6T1

Proteomic databases

EPDiQ9D6T1
MaxQBiQ9D6T1
PaxDbiQ9D6T1
PeptideAtlasiQ9D6T1
PRIDEiQ9D6T1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019991; ENSMUSP00000019991; ENSMUSG00000019845
GeneIDi71924
KEGGimmu:71924
UCSCiuc007evu.1 mouse

Organism-specific databases

CTDi51175
MGIiMGI:1919174 Tube1

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00930000150956
HOGENOMiHOG000165713
HOVERGENiHBG098062
InParanoidiQ9D6T1
KOiK10391
OMAiYNQLDAT
OrthoDBiEOG091G06O0
PhylomeDBiQ9D6T1
TreeFamiTF330882

Miscellaneous databases

PROiPR:Q9D6T1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019845 Expressed in 184 organ(s), highest expression level in secondary oocyte
CleanExiMM_TUBE1
ExpressionAtlasiQ9D6T1 baseline and differential
GenevisibleiQ9D6T1 MM

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR004057 Epsilon_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF13 PTHR11588:SF13, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01519 EPSLNTUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBE_MOUSE
AccessioniPrimary (citable) accession number: Q9D6T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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