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Protein

Calmodulin-like protein 3

Gene

Calml3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity).By similarity

Miscellaneous

Binds four calcium ions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 3
Gene namesi
Name:Calml3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1917655 Calml3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845211 – 149Calmodulin-like protein 3Add BLAST149

Proteomic databases

MaxQBiQ9D6P8
PaxDbiQ9D6P8
PeptideAtlasiQ9D6P8
PRIDEiQ9D6P8

PTM databases

iPTMnetiQ9D6P8
PhosphoSitePlusiQ9D6P8

Expressioni

Gene expression databases

BgeeiENSMUSG00000063130 Expressed in 84 organ(s), highest expression level in cornea
CleanExiMM_CALML3
ExpressionAtlasiQ9D6P8 baseline and differential
GenevisibleiQ9D6P8 MM

Interactioni

Subunit structurei

Interacts with MYO10, the interaction is calcium-dependent and essential for MYO10 function in filopodial extension.By similarity

Protein-protein interaction databases

BioGridi214028, 144 interactors
IntActiQ9D6P8, 147 interactors
STRINGi10090.ENSMUSP00000076880

Structurei

3D structure databases

ProteinModelPortaliQ9D6P8
SMRiQ9D6P8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ9D6P8
KOiK02183
OMAiCITTQEL
OrthoDBiEOG091G0V73
PhylomeDBiQ9D6P8
TreeFamiTF300912

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D6P8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGSITT QELGTVMRSL GQNPTEAELQ
60 70 80 90 100
GMVNEIDKDG NGTVDFPEFL TMMSRKMKDT DSEEEIREAF RVFDKDGNGF
110 120 130 140
VSAAELRHVM TKLGEKLSDE EVDEMIQAAD TDGDGQVNYE EFVHMLVSK
Length:149
Mass (Da):16,701
Last modified:June 1, 2001 - v1
Checksum:iB4BA3C842D7186E0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VK66A0A1Y7VK66_MOUSE
Calmodulin-like protein 3
Calml3
115Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68E → K in AAH05457 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010118 mRNA Translation: BAB26712.1
BC005457 mRNA Translation: AAH05457.1
CCDSiCCDS26214.1
RefSeqiNP_081692.1, NM_027416.3
UniGeneiMm.20079

Genome annotation databases

EnsembliENSMUST00000077698; ENSMUSP00000076880; ENSMUSG00000063130
GeneIDi70405
KEGGimmu:70405
UCSCiuc007pja.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010118 mRNA Translation: BAB26712.1
BC005457 mRNA Translation: AAH05457.1
CCDSiCCDS26214.1
RefSeqiNP_081692.1, NM_027416.3
UniGeneiMm.20079

3D structure databases

ProteinModelPortaliQ9D6P8
SMRiQ9D6P8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214028, 144 interactors
IntActiQ9D6P8, 147 interactors
STRINGi10090.ENSMUSP00000076880

PTM databases

iPTMnetiQ9D6P8
PhosphoSitePlusiQ9D6P8

Proteomic databases

MaxQBiQ9D6P8
PaxDbiQ9D6P8
PeptideAtlasiQ9D6P8
PRIDEiQ9D6P8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077698; ENSMUSP00000076880; ENSMUSG00000063130
GeneIDi70405
KEGGimmu:70405
UCSCiuc007pja.2 mouse

Organism-specific databases

CTDi810
MGIiMGI:1917655 Calml3

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ9D6P8
KOiK02183
OMAiCITTQEL
OrthoDBiEOG091G0V73
PhylomeDBiQ9D6P8
TreeFamiTF300912

Miscellaneous databases

PROiPR:Q9D6P8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063130 Expressed in 84 organ(s), highest expression level in cornea
CleanExiMM_CALML3
ExpressionAtlasiQ9D6P8 baseline and differential
GenevisibleiQ9D6P8 MM

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCALL3_MOUSE
AccessioniPrimary (citable) accession number: Q9D6P8
Secondary accession number(s): Q99K52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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