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Protein

Dr1-associated corepressor

Gene

Drap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: MGI
  • protein heterodimerization activity Source: InterPro
  • transcription corepressor activity Source: MGI
  • transcription factor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-1181150 Signaling by NODAL
R-MMU-1502540 Signaling by Activin

Names & Taxonomyi

Protein namesi
Recommended name:
Dr1-associated corepressor
Alternative name(s):
Dr1-associated protein 1
Negative cofactor 2-alpha
Short name:
NC2-alpha
Gene namesi
Name:Drap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1913806 Drap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000800021 – 205Dr1-associated corepressorAdd BLAST205

Post-translational modificationi

Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D6N5
MaxQBiQ9D6N5
PaxDbiQ9D6N5
PRIDEiQ9D6N5

PTM databases

iPTMnetiQ9D6N5
PhosphoSitePlusiQ9D6N5

Expressioni

Gene expression databases

BgeeiENSMUSG00000024914
ExpressionAtlasiQ9D6N5 baseline and differential
GenevisibleiQ9D6N5 MM

Interactioni

Subunit structurei

Heterodimer with DR1. Binds BTAF1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025853

Structurei

3D structure databases

ProteinModelPortaliQ9D6N5
SMRiQ9D6N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 77Histone-foldAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 7Poly-Lys4
Compositional biasi156 – 192Pro-richAdd BLAST37

Sequence similaritiesi

Belongs to the NC2 alpha/DRAP1 family.Curated

Phylogenomic databases

eggNOGiKOG1659 Eukaryota
COG5247 LUCA
GeneTreeiENSGT00390000012424
HOGENOMiHOG000113741
HOVERGENiHBG051403
InParanoidiQ9D6N5
KOiK21752
PhylomeDBiQ9D6N5
TreeFamiTF313964

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKKKKYNA RFPPARIKKI MQTDEEIGKV AAAVPVIISR ALELFLESLL
60 70 80 90 100
KKACQVTQSR NAKTMTTSHL KQCIELEQQF DFLKDLVASV PDMQGDGEDN
110 120 130 140 150
HVDGDKGPRR GRKPGSSGRK NGGTGSKGKD KKLSGTDSEQ EDESEDTDTD
160 170 180 190 200
GEEETPQLPP QASHPPAHFQ SPPTPFIPFT SPLPLPPAPP GPSAADAEDE

EDYDS
Length:205
Mass (Da):22,278
Last modified:January 23, 2007 - v3
Checksum:i59CB729FFD7CB7CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010152 mRNA Translation: BAB26737.1
AK087456 mRNA Translation: BAC39882.1
BC002090 mRNA Translation: AAH02090.1
CCDSiCCDS29462.1
RefSeqiNP_001278009.1, NM_001291080.1
NP_077138.1, NM_024176.2
UniGeneiMm.275446

Genome annotation databases

EnsembliENSMUST00000025853; ENSMUSP00000025853; ENSMUSG00000024914
GeneIDi66556
KEGGimmu:66556
UCSCiuc008gcy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNC2A_MOUSE
AccessioniPrimary (citable) accession number: Q9D6N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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