UniProtKB - Q9D6N1 (CAH13_MOUSE)
Protein
Carbonic anhydrase 13
Gene
Ca13
Organism
Mus musculus (Mouse)
Status
Functioni
Reversible hydration of carbon dioxide.
Catalytic activityi
- EC:4.2.1.1
Cofactori
Zn2+By similarity
Activity regulationi
Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).3 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 65 | Proton donor/acceptorBy similarity | 1 | |
Metal bindingi | 95 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 97 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 120 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- carbonate dehydratase activity Source: MGI
- hydro-lyase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- one-carbon metabolic process Source: GO_Central
Keywordsi
Molecular function | Lyase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 4.2.1.1, 3474 |
Reactomei | R-MMU-1475029, Reversible hydration of carbon dioxide |
Names & Taxonomyi
Protein namesi | Recommended name: Carbonic anhydrase 13 (EC:4.2.1.1)Alternative name(s): Carbonate dehydratase XIII Carbonic anhydrase XIII Short name: CA-XIII |
Gene namesi | Name:Ca13 Synonyms:Car13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1931322, Car13 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: MGI
- myelin sheath Source: MGI
Pathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL2186 |
DrugCentrali | Q9D6N1 |
GuidetoPHARMACOLOGYi | 2748 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000077441 | 1 – 262 | Carbonic anhydrase 13Add BLAST | 262 |
Proteomic databases
MaxQBi | Q9D6N1 |
PaxDbi | Q9D6N1 |
PeptideAtlasi | Q9D6N1 |
PRIDEi | Q9D6N1 |
PTM databases
iPTMneti | Q9D6N1 |
PhosphoSitePlusi | Q9D6N1 |
Expressioni
Tissue specificityi
Expressed in spleen, lung, kidney, heart, brain, skeletal muscle and testis.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000027555, Expressed in meninx of telencephalon and 233 other tissues |
Genevisiblei | Q9D6N1, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000029071 |
Chemistry databases
BindingDBi | Q9D6N1 |
Miscellaneous databases
RNActi | Q9D6N1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 261 | Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST | 258 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 200 – 201 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the alpha-carbonic anhydrase family.Curated
Phylogenomic databases
eggNOGi | KOG0382, Eukaryota |
GeneTreei | ENSGT00940000160659 |
HOGENOMi | CLU_039326_2_1_1 |
InParanoidi | Q9D6N1 |
OMAi | PIHWNEL |
OrthoDBi | 1377476at2759 |
PhylomeDBi | Q9D6N1 |
TreeFami | TF316425 |
Family and domain databases
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class IPR018338, Carbonic_anhydrase_a-class_CS |
PANTHERi | PTHR18952, PTHR18952, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162, ALPHA_CA_1, 1 hit PS51144, ALPHA_CA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9D6N1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARLSWGYGE HNGPIHWNEL FPIADGDQQS PIEIKTKEVK YDSSLRPLSI
60 70 80 90 100
KYDPASAKII SNSGHSFNVD FDDTEDKSVL RGGPLTGNYR LRQFHLHWGS
110 120 130 140 150
ADDHGSEHVV DGVRYAAELH VVHWNSDKYP SFVEAAHESD GLAVLGVFLQ
160 170 180 190 200
IGEHNPQLQK ITDILDSIKE KGKQTRFTNF DPLCLLPSSW DYWTYPGSLT
210 220 230 240 250
VPPLLESVTW IVLKQPISIS SQQLARFRSL LCTAEGESAA FLLSNHRPPQ
260
PLKGRRVRAS FY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF231123 mRNA Translation: AAK16672.1 AK010166 mRNA Translation: BAB26742.1 AK150871 mRNA Translation: BAE29922.1 AK150897 mRNA Translation: BAE29942.1 AK151519 mRNA Translation: BAE30468.1 AK151978 mRNA Translation: BAE30845.1 AK153080 mRNA Translation: BAE31705.1 AK153258 mRNA Translation: BAE31849.1 AK153353 mRNA Translation: BAE31927.1 AK162621 mRNA Translation: BAE36996.1 BC064050 mRNA Translation: AAH64050.1 |
CCDSi | CCDS17247.1 |
RefSeqi | NP_078771.1, NM_024495.5 |
Genome annotation databases
Ensembli | ENSMUST00000029071; ENSMUSP00000029071; ENSMUSG00000027555 |
GeneIDi | 71934 |
KEGGi | mmu:71934 |
UCSCi | uc008oqo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF231123 mRNA Translation: AAK16672.1 AK010166 mRNA Translation: BAB26742.1 AK150871 mRNA Translation: BAE29922.1 AK150897 mRNA Translation: BAE29942.1 AK151519 mRNA Translation: BAE30468.1 AK151978 mRNA Translation: BAE30845.1 AK153080 mRNA Translation: BAE31705.1 AK153258 mRNA Translation: BAE31849.1 AK153353 mRNA Translation: BAE31927.1 AK162621 mRNA Translation: BAE36996.1 BC064050 mRNA Translation: AAH64050.1 |
CCDSi | CCDS17247.1 |
RefSeqi | NP_078771.1, NM_024495.5 |
3D structure databases
SMRi | Q9D6N1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000029071 |
Chemistry databases
BindingDBi | Q9D6N1 |
ChEMBLi | CHEMBL2186 |
DrugCentrali | Q9D6N1 |
GuidetoPHARMACOLOGYi | 2748 |
PTM databases
iPTMneti | Q9D6N1 |
PhosphoSitePlusi | Q9D6N1 |
Proteomic databases
MaxQBi | Q9D6N1 |
PaxDbi | Q9D6N1 |
PeptideAtlasi | Q9D6N1 |
PRIDEi | Q9D6N1 |
Protocols and materials databases
Antibodypediai | 12589, 185 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000029071; ENSMUSP00000029071; ENSMUSG00000027555 |
GeneIDi | 71934 |
KEGGi | mmu:71934 |
UCSCi | uc008oqo.2, mouse |
Organism-specific databases
CTDi | 71934 |
MGIi | MGI:1931322, Car13 |
Phylogenomic databases
eggNOGi | KOG0382, Eukaryota |
GeneTreei | ENSGT00940000160659 |
HOGENOMi | CLU_039326_2_1_1 |
InParanoidi | Q9D6N1 |
OMAi | PIHWNEL |
OrthoDBi | 1377476at2759 |
PhylomeDBi | Q9D6N1 |
TreeFami | TF316425 |
Enzyme and pathway databases
BRENDAi | 4.2.1.1, 3474 |
Reactomei | R-MMU-1475029, Reversible hydration of carbon dioxide |
Miscellaneous databases
BioGRID-ORCSi | 71934, 1 hit in 17 CRISPR screens |
PROi | PR:Q9D6N1 |
RNActi | Q9D6N1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027555, Expressed in meninx of telencephalon and 233 other tissues |
Genevisiblei | Q9D6N1, MM |
Family and domain databases
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class IPR018338, Carbonic_anhydrase_a-class_CS |
PANTHERi | PTHR18952, PTHR18952, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162, ALPHA_CA_1, 1 hit PS51144, ALPHA_CA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAH13_MOUSE | |
Accessioni | Q9D6N1Primary (citable) accession number: Q9D6N1 Secondary accession number(s): Q3UBM2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 9, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families