Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial glutamate carrier 1

Gene

Slc25a22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-428643 Organic anion transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glutamate carrier 1
Short name:
GC-1
Alternative name(s):
Glutamate/H(+) symporter 1
Solute carrier family 25 member 22
Gene namesi
Name:Slc25a22
Synonyms:Gc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915517 Slc25a22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei292 – 312Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906201 – 323Mitochondrial glutamate carrier 1Add BLAST323

Proteomic databases

EPDiQ9D6M3
MaxQBiQ9D6M3
PeptideAtlasiQ9D6M3
PRIDEiQ9D6M3

PTM databases

iPTMnetiQ9D6M3
PhosphoSitePlusiQ9D6M3
SwissPalmiQ9D6M3

Expressioni

Gene expression databases

BgeeiENSMUSG00000019082 Expressed in 277 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ9D6M3 baseline and differential
GenevisibleiQ9D6M3 MM

Interactioni

Protein-protein interaction databases

BioGridi212770, 4 interactors
IntActiQ9D6M3, 8 interactors
MINTiQ9D6M3

Structurei

3D structure databases

ProteinModelPortaliQ9D6M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 93Solcar 1Add BLAST88
Repeati101 – 214Solcar 2Add BLAST114
Repeati223 – 312Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062944
HOGENOMiHOG000168308
HOVERGENiHBG039469
InParanoidiQ9D6M3
KOiK15107
OMAiRKLMPET
OrthoDBiEOG091G08GT
PhylomeDBiQ9D6M3
TreeFamiTF313209

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

Q9D6M3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKQISLPA KLINGGIAGL IGVTCVFPID LAKTRLQNQQ NGQRMYASMS
60 70 80 90 100
DCLIKTIRSE GYFGMYRGAA VNLTLVTPEK AIKLAANDFF RHQLSKDGQK
110 120 130 140 150
LTLPKEMLAG CGAGTCQVIV TTPMEMLKIQ LQDAGRIAAQ RKILAAQAQL
160 170 180 190 200
SAQGGAQPSV EAPAPPRPTA TQLTRDLLRN HGIAGLYKGL GATLLRDVPF
210 220 230 240 250
SIVYFPLFAN LNQLGRPSSE EKSPFYVSFL AGCVAGSAAA VAVNPCDVVK
260 270 280 290 300
TRLQSLERGV NEDTYSGFLD CARKIWRHEG PSAFLKGAYC RALVIAPLFG
310 320
IAQVVYFLGI AESLLGLLQE PQA
Length:323
Mass (Da):34,670
Last modified:June 1, 2001 - v1
Checksum:iCCAED09AB4CF73AE
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80X52Q80X52_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
98Annotation score:
E9Q579E9Q579_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
103Annotation score:
E9PV90E9PV90_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
206Annotation score:
E9PY45E9PY45_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
222Annotation score:
A0A0J9YTY6A0A0J9YTY6_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
196Annotation score:
E9Q6M6E9Q6M6_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
229Annotation score:
A0A0J9YUJ4A0A0J9YUJ4_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
72Annotation score:
A0A0J9YUX4A0A0J9YUX4_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
85Annotation score:
V9GWS2V9GWS2_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
63Annotation score:
G3UX09G3UX09_MOUSE
Mitochondrial glutamate carrier 1
Slc25a22
38Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010193 mRNA Translation: BAB26760.1
AK046874 mRNA Translation: BAC32903.1
AK048389 mRNA Translation: BAC33318.1
AK049313 mRNA Translation: BAC33676.1
AK155276 mRNA Translation: BAE33159.1
AK162400 mRNA Translation: BAE36895.1
BC037949 mRNA Translation: AAH37949.1
CCDSiCCDS22013.1
RefSeqiNP_001171047.1, NM_001177576.1
NP_080922.1, NM_026646.3
XP_006536295.1, XM_006536232.1
XP_006536296.1, XM_006536233.3
UniGeneiMm.33729

Genome annotation databases

EnsembliENSMUST00000019226; ENSMUSP00000019226; ENSMUSG00000019082
ENSMUST00000106007; ENSMUSP00000101629; ENSMUSG00000019082
ENSMUST00000201710; ENSMUSP00000144231; ENSMUSG00000019082
GeneIDi68267
KEGGimmu:68267
UCSCiuc009kkz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010193 mRNA Translation: BAB26760.1
AK046874 mRNA Translation: BAC32903.1
AK048389 mRNA Translation: BAC33318.1
AK049313 mRNA Translation: BAC33676.1
AK155276 mRNA Translation: BAE33159.1
AK162400 mRNA Translation: BAE36895.1
BC037949 mRNA Translation: AAH37949.1
CCDSiCCDS22013.1
RefSeqiNP_001171047.1, NM_001177576.1
NP_080922.1, NM_026646.3
XP_006536295.1, XM_006536232.1
XP_006536296.1, XM_006536233.3
UniGeneiMm.33729

3D structure databases

ProteinModelPortaliQ9D6M3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212770, 4 interactors
IntActiQ9D6M3, 8 interactors
MINTiQ9D6M3

PTM databases

iPTMnetiQ9D6M3
PhosphoSitePlusiQ9D6M3
SwissPalmiQ9D6M3

Proteomic databases

EPDiQ9D6M3
MaxQBiQ9D6M3
PeptideAtlasiQ9D6M3
PRIDEiQ9D6M3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019226; ENSMUSP00000019226; ENSMUSG00000019082
ENSMUST00000106007; ENSMUSP00000101629; ENSMUSG00000019082
ENSMUST00000201710; ENSMUSP00000144231; ENSMUSG00000019082
GeneIDi68267
KEGGimmu:68267
UCSCiuc009kkz.2 mouse

Organism-specific databases

CTDi79751
MGIiMGI:1915517 Slc25a22

Phylogenomic databases

GeneTreeiENSGT00530000062944
HOGENOMiHOG000168308
HOVERGENiHBG039469
InParanoidiQ9D6M3
KOiK15107
OMAiRKLMPET
OrthoDBiEOG091G08GT
PhylomeDBiQ9D6M3
TreeFamiTF313209

Enzyme and pathway databases

ReactomeiR-MMU-428643 Organic anion transporters

Miscellaneous databases

ChiTaRSiGucy2e mouse
PROiPR:Q9D6M3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019082 Expressed in 277 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ9D6M3 baseline and differential
GenevisibleiQ9D6M3 MM

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGHC1_MOUSE
AccessioniPrimary (citable) accession number: Q9D6M3
Secondary accession number(s): Q3TRY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again