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Entry version 104 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

FUN14 domain-containing protein 2

Gene

Fundc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FUN14 domain-containing protein 2
Alternative name(s):
Hepatitis C virus core-binding protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fundc2
Synonyms:Hcbp6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914641 Fundc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003146171 – 151FUN14 domain-containing protein 2Add BLAST151

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9D6K8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9D6K8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9D6K8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9D6K8

PeptideAtlas

More...
PeptideAtlasi
Q9D6K8

PRoteomics IDEntifications database

More...
PRIDEi
Q9D6K8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9D6K8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9D6K8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9D6K8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031198 Expressed in 267 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9D6K8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9D6K8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033541

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9D6K8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FUN14 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4099 Eukaryota
ENOG41122V1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154783

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232100

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9D6K8

Identification of Orthologs from Complete Genome Data

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OMAi
KQPWWRT

Database of Orthologous Groups

More...
OrthoDBi
1431148at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9D6K8

TreeFam database of animal gene trees

More...
TreeFami
TF300280

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007014 FUN14

The PANTHER Classification System

More...
PANTHERi
PTHR21346 PTHR21346, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04930 FUN14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9D6K8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAANSQGNFD GKFEALDLAE LTKKQPWWRK LFGQESGPSA EKYSVATQLV
60 70 80 90 100
IGGVTGWCTG FVFQKVGKLA ATAVGGGFFL LQLANHTGYI KVDWQRVEKD
110 120 130 140 150
MKKAKEQLKI RKNKQIPTEV KSKAEEVVSF VKKNVLVTGG FFGGFLLGMA

S
Length:151
Mass (Da):16,564
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EC4C8B9301D64ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30 – 31KL → NS in BAB29513 (PubMed:16141072).Curated2
Sequence conflicti73A → D in BAC27304 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY234858 mRNA Translation: AAO89275.1
AK013460 mRNA Translation: BAB28867.1
AK014705 mRNA Translation: BAB29513.1
AK031214 mRNA Translation: BAC27304.1
AL731844 Genomic DNA No translation available.
BC042794 mRNA Translation: AAH42794.1
BC049566 mRNA Translation: AAH49566.2
BC061464 mRNA Translation: AAH61464.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30239.1

NCBI Reference Sequences

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RefSeqi
NP_080402.3, NM_026126.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033541; ENSMUSP00000033541; ENSMUSG00000031198

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67391

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67391

UCSC genome browser

More...
UCSCi
uc009tpu.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234858 mRNA Translation: AAO89275.1
AK013460 mRNA Translation: BAB28867.1
AK014705 mRNA Translation: BAB29513.1
AK031214 mRNA Translation: BAC27304.1
AL731844 Genomic DNA No translation available.
BC042794 mRNA Translation: AAH42794.1
BC049566 mRNA Translation: AAH49566.2
BC061464 mRNA Translation: AAH61464.1
CCDSiCCDS30239.1
RefSeqiNP_080402.3, NM_026126.4

3D structure databases

SMRiQ9D6K8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9D6K8, 1 interactor
STRINGi10090.ENSMUSP00000033541

PTM databases

iPTMnetiQ9D6K8
PhosphoSitePlusiQ9D6K8
SwissPalmiQ9D6K8

Proteomic databases

EPDiQ9D6K8
jPOSTiQ9D6K8
MaxQBiQ9D6K8
PaxDbiQ9D6K8
PeptideAtlasiQ9D6K8
PRIDEiQ9D6K8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
67391

Genome annotation databases

EnsembliENSMUST00000033541; ENSMUSP00000033541; ENSMUSG00000031198
GeneIDi67391
KEGGimmu:67391
UCSCiuc009tpu.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65991
MGIiMGI:1914641 Fundc2

Phylogenomic databases

eggNOGiKOG4099 Eukaryota
ENOG41122V1 LUCA
GeneTreeiENSGT00940000154783
HOGENOMiHOG000232100
InParanoidiQ9D6K8
OMAiKQPWWRT
OrthoDBi1431148at2759
PhylomeDBiQ9D6K8
TreeFamiTF300280

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fundc2 mouse

Protein Ontology

More...
PROi
PR:Q9D6K8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031198 Expressed in 267 organ(s), highest expression level in blood
GenevisibleiQ9D6K8 MM

Family and domain databases

InterProiView protein in InterPro
IPR007014 FUN14
PANTHERiPTHR21346 PTHR21346, 1 hit
PfamiView protein in Pfam
PF04930 FUN14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUND2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D6K8
Secondary accession number(s): Q80VT2
, Q80YD9, Q8BSM8, Q9D617
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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