UniProtKB - Q9D6K5 (SYJ2B_MOUSE)
Synaptojanin-2-binding protein
Synj2bp
Functioni
GO - Molecular functioni
- protein C-terminus binding Source: MGI
- type II activin receptor binding Source: UniProtKB
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- cytoplasm organization Source: MGI
- endocytosis Source: UniProtKB-KW
- establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
- intracellular distribution of mitochondria Source: MGI
- negative regulation of activin receptor signaling pathway Source: UniProtKB
- negative regulation of angiogenesis Source: UniProtKB
- negative regulation of endothelial cell migration Source: UniProtKB
- negative regulation of endothelial cell proliferation Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
- negative regulation of sprouting angiogenesis Source: UniProtKB
- positive regulation of activin receptor signaling pathway Source: UniProtKB
- positive regulation of protein localization to cell surface Source: UniProtKB
- positive regulation of receptor internalization Source: UniProtKB
- protein targeting Source: MGI
- receptor clustering Source: GO_Central
- receptor localization to synapse Source: GO_Central
- regulation of endocytosis Source: MGI
- regulation of Notch signaling pathway Source: UniProtKB
- Rho protein signal transduction Source: MGI
Keywordsi
Biological process | Endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptojanin-2-binding proteinBy similarityAlternative name(s): Activin receptor-interacting protein 21 Publication Activin receptor-interacting protein 4Imported Mitochondrial outer membrane protein 25By similarity |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1344347, Synj2bp |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane By similarity; Single-pass type IV membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- perinuclear region 1 Publication
Mitochondrion
- integral component of mitochondrial outer membrane Source: MGI
- mitochondrial outer membrane Source: MGI
- mitochondrion Source: MGI
Plasma Membrane
- basolateral plasma membrane Source: GO_Central
- postsynaptic density membrane Source: GO_Central
Other locations
- cell junction Source: GO_Central
- cell surface Source: UniProtKB
- neuromuscular junction Source: GO_Central
- neuron projection Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 117 | CytoplasmicSequence analysisAdd BLAST | 117 | |
Transmembranei | 118 – 138 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 145 | Mitochondrial intermembraneSequence analysis | 7 |
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000375982 | 1 – 145 | Synaptojanin-2-binding proteinAdd BLAST | 145 |
Proteomic databases
EPDi | Q9D6K5 |
jPOSTi | Q9D6K5 |
PaxDbi | Q9D6K5 |
PeptideAtlasi | Q9D6K5 |
PRIDEi | Q9D6K5 |
PTM databases
iPTMneti | Q9D6K5 |
PhosphoSitePlusi | Q9D6K5 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000021139, Expressed in spermatid and 53 other tissues |
ExpressionAtlasi | Q9D6K5, baseline and differential |
Genevisiblei | Q9D6K5, MM |
Interactioni
Subunit structurei
Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) (By similarity).
Interacts (via C-terminus) with RALBP1.
Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus).
Forms a ternary complex with ACVR2A and RALBP1 (PubMed:11882656, PubMed:16648306).
Interacts with MAPK12 (By similarity).
Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells (By similarity).
By similarity2 PublicationsBinary interactionsi
Q9D6K5
With | #Exp. | IntAct |
---|---|---|
Lrp2 [A2ARV4] | 2 | EBI-300910,EBI-300875 |
GO - Molecular functioni
- protein C-terminus binding Source: MGI
- type II activin receptor binding Source: UniProtKB
Protein-protein interaction databases
IntActi | Q9D6K5, 4 interactors |
STRINGi | 10090.ENSMUSP00000129224 |
Miscellaneous databases
RNActi | Q9D6K5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 100 | PDZPROSITE-ProRule annotationAdd BLAST | 88 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00830000128402 |
HOGENOMi | CLU_149433_1_0_1 |
InParanoidi | Q9D6K5 |
OMAi | MMDPELE |
OrthoDBi | 1333715at2759 |
PhylomeDBi | Q9D6K5 |
TreeFami | TF318964 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKED
60 70 80 90 100
GAAAQDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGC AVSLRVQHRL
110 120 130 140
PVQNGPIVHR GEGEPSGVPV AMVLLPVFAL TMVAVWAFVR YRKQL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PVN6 | E9PVN6_MOUSE | Cytochrome c oxidase assembly prote... | Gm20498 | 182 | Annotation score: | ||
E9PVQ9 | E9PVQ9_MOUSE | Predicted gene 20498 | Synj2bp Gm20498 | 40 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | Q → E in BAB25432 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053101 | 1 – 20 | MNGRV…LTRGP → MIF in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_053102 | 100 – 118 | LPVQN…EPSGV → VGITCTWIWDSRLLHCSCE in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 19 | |
Alternative sequenceiVSP_053103 | 101 – 145 | PVQNG…YRKQL → LVVGGSFGLREFSQIRYDAV TIKIDPELEKKLKVNKITLE SEYERLLCLLCRQ in isoform 4. 2 PublicationsAdd BLAST | 45 | |
Alternative sequenceiVSP_053104 | 119 – 145 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF414433 mRNA Translation: AAM43958.1 AY071903 mRNA Translation: AAL60065.1 AY157057 mRNA Translation: AAO12271.1 AY138960 mRNA Translation: AAN17786.1 AY566156 mRNA Translation: AAT70239.1 AK008054 mRNA Translation: BAB25432.1 AK013474 mRNA Translation: BAB28873.1 AK033514 mRNA Translation: BAC28333.1 AK163362 mRNA Translation: BAE37317.1 BC027433 mRNA Translation: AAH27433.2 Different initiation. |
CCDSi | CCDS26021.1 [Q9D6K5-1] CCDS83979.1 [Q9D6K5-2] |
RefSeqi | NP_001296743.1, NM_001309814.1 [Q9D6K5-2] NP_001296777.1, NM_001309848.1 [Q9D6K5-4] NP_079568.1, NM_025292.7 [Q9D6K5-1] |
Genome annotation databases
Ensembli | ENSMUST00000114201; ENSMUSP00000109839; ENSMUSG00000090935 [Q9D6K5-3] ENSMUST00000163402; ENSMUSP00000129224; ENSMUSG00000090935 [Q9D6K5-1] ENSMUST00000164386; ENSMUSP00000132941; ENSMUSG00000021139 [Q9D6K5-4] ENSMUST00000169158; ENSMUSP00000130691; ENSMUSG00000090935 [Q9D6K5-2] |
GeneIDi | 105940408 24071 |
KEGGi | mmu:105940408 mmu:24071 |
UCSCi | uc007oca.1, mouse [Q9D6K5-4] uc007och.2, mouse [Q9D6K5-1] uc007ocj.2, mouse [Q9D6K5-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF414433 mRNA Translation: AAM43958.1 AY071903 mRNA Translation: AAL60065.1 AY157057 mRNA Translation: AAO12271.1 AY138960 mRNA Translation: AAN17786.1 AY566156 mRNA Translation: AAT70239.1 AK008054 mRNA Translation: BAB25432.1 AK013474 mRNA Translation: BAB28873.1 AK033514 mRNA Translation: BAC28333.1 AK163362 mRNA Translation: BAE37317.1 BC027433 mRNA Translation: AAH27433.2 Different initiation. |
CCDSi | CCDS26021.1 [Q9D6K5-1] CCDS83979.1 [Q9D6K5-2] |
RefSeqi | NP_001296743.1, NM_001309814.1 [Q9D6K5-2] NP_001296777.1, NM_001309848.1 [Q9D6K5-4] NP_079568.1, NM_025292.7 [Q9D6K5-1] |
3D structure databases
SMRi | Q9D6K5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9D6K5, 4 interactors |
STRINGi | 10090.ENSMUSP00000129224 |
PTM databases
iPTMneti | Q9D6K5 |
PhosphoSitePlusi | Q9D6K5 |
Proteomic databases
EPDi | Q9D6K5 |
jPOSTi | Q9D6K5 |
PaxDbi | Q9D6K5 |
PeptideAtlasi | Q9D6K5 |
PRIDEi | Q9D6K5 |
Protocols and materials databases
Antibodypediai | 46, 114 antibodies |
DNASUi | 24071 |
Genome annotation databases
Ensembli | ENSMUST00000114201; ENSMUSP00000109839; ENSMUSG00000090935 [Q9D6K5-3] ENSMUST00000163402; ENSMUSP00000129224; ENSMUSG00000090935 [Q9D6K5-1] ENSMUST00000164386; ENSMUSP00000132941; ENSMUSG00000021139 [Q9D6K5-4] ENSMUST00000169158; ENSMUSP00000130691; ENSMUSG00000090935 [Q9D6K5-2] |
GeneIDi | 105940408 24071 |
KEGGi | mmu:105940408 mmu:24071 |
UCSCi | uc007oca.1, mouse [Q9D6K5-4] uc007och.2, mouse [Q9D6K5-1] uc007ocj.2, mouse [Q9D6K5-2] |
Organism-specific databases
CTDi | 55333 |
MGIi | MGI:1344347, Synj2bp |
Phylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00830000128402 |
HOGENOMi | CLU_149433_1_0_1 |
InParanoidi | Q9D6K5 |
OMAi | MMDPELE |
OrthoDBi | 1333715at2759 |
PhylomeDBi | Q9D6K5 |
TreeFami | TF318964 |
Miscellaneous databases
BioGRID-ORCSi | 24071, 0 hits in 17 CRISPR screens |
PROi | PR:Q9D6K5 |
RNActi | Q9D6K5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021139, Expressed in spermatid and 53 other tissues |
ExpressionAtlasi | Q9D6K5, baseline and differential |
Genevisiblei | Q9D6K5, MM |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYJ2B_MOUSE | |
Accessioni | Q9D6K5Primary (citable) accession number: Q9D6K5 Secondary accession number(s): Q2TTN6 Q9D8G4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot