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Protein

Intraflagellar transport protein 25 homolog

Gene

Hspb11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly.1 Publication

Caution

Was initially classified as a member of the small heat shock family protein. However, it was later shown that it is not the case (PubMed:22595669).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Calcium; via carbonyl oxygenBy similarity1
Metal bindingi32CalciumBy similarity1
Metal bindingi37CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • heart development Source: MGI
  • intraciliary transport Source: MGI
  • left/right axis specification Source: MGI
  • lung development Source: MGI
  • protein transport Source: UniProtKB-KW
  • skeletal system development Source: MGI
  • smoothened signaling pathway Source: UniProtKB

Keywordsi

Biological processProtein transport, Stress response, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 25 homolog
Alternative name(s):
Heat shock protein beta-11
Short name:
Hspb11
Placental protein 25
Short name:
PP25
Gene namesi
Name:Hspb11
Synonyms:Ift25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920188 Hspb11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Disruption phenotypei

Null mutants retain the ability to ciliate and survive through gestation. They die shortly after birth due to different phenotypes reminiscent of Shh signaling defects: polydactyly, cleft palate, lung isomerisms, and structural heart defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585321 – 143Intraflagellar transport protein 25 homologAdd BLAST143

Proteomic databases

EPDiQ9D6H2
MaxQBiQ9D6H2
PaxDbiQ9D6H2
PeptideAtlasiQ9D6H2
PRIDEiQ9D6H2

PTM databases

PhosphoSitePlusiQ9D6H2

Expressioni

Gene expression databases

BgeeiENSMUSG00000063172
GenevisibleiQ9D6H2 MM

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27; the interaction is direct. Interacts with IFT88.2 Publications

Protein-protein interaction databases

BioGridi215658, 2 interactors
STRINGi10090.ENSMUSP00000048810

Structurei

3D structure databases

ProteinModelPortaliQ9D6H2
SMRiQ9D6H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFT25 family.Curated

Phylogenomic databases

eggNOGiENOG410INPG Eukaryota
ENOG4111WDR LUCA
GeneTreeiENSGT00390000012620
HOGENOMiHOG000232198
HOVERGENiHBG060331
InParanoidiQ9D6H2
KOiK19369
OMAiHATYLRF
OrthoDBiEOG091G0RG0
PhylomeDBiQ9D6H2
TreeFamiTF336031

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR033558 IFT25
PANTHERiPTHR33906 PTHR33906, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D6H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKVDLCSVT EGTEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI
60 70 80 90 100
ICFHKHVKIE KLVIQSYLVR TLRIEKTTSK EPLDFEQWVE KDLVHTEGQL
110 120 130 140
QNEEIVARDG YATFLRFIIV SAFDHFASVH SISAEGLTVS SLP
Length:143
Mass (Da):16,281
Last modified:October 3, 2012 - v2
Checksum:iC05B1E8A496DB5EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74I → T in BAB28934 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013636 mRNA Translation: BAB28934.1
AK157651 mRNA Translation: BAE34145.1
AL645723 Genomic DNA No translation available.
CH466527 Genomic DNA Translation: EDL30781.1
CH466527 Genomic DNA Translation: EDL30782.1
CH466527 Genomic DNA Translation: EDL30783.1
CCDSiCCDS18435.1
RefSeqiNP_082670.1, NM_028394.2
XP_006503487.1, XM_006503424.3
XP_006503488.1, XM_006503425.1
XP_006503489.1, XM_006503426.2
UniGeneiMm.21787

Genome annotation databases

EnsembliENSMUST00000046558; ENSMUSP00000048810; ENSMUSG00000063172
ENSMUST00000106749; ENSMUSP00000102360; ENSMUSG00000063172
ENSMUST00000152717; ENSMUSP00000118617; ENSMUSG00000063172
GeneIDi72938
KEGGimmu:72938
UCSCiuc008tzn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIFT25_MOUSE
AccessioniPrimary (citable) accession number: Q9D6H2
Secondary accession number(s): Q3TZR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 3, 2012
Last modified: April 25, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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