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Protein

Serpin B7

Gene

Serpinb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei347 – 348Reactive bondBy similarity2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.012

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B7
Alternative name(s):
Megsin
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2151053 Serpinb7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941091 – 380Serpin B7Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D695
PaxDbiQ9D695
PRIDEiQ9D695

PTM databases

iPTMnetiQ9D695
PhosphoSitePlusiQ9D695

Expressioni

Gene expression databases

BgeeiENSMUSG00000067001 Expressed in 43 organ(s), highest expression level in skin epidermis
ExpressionAtlasiQ9D695 baseline and differential
GenevisibleiQ9D695 MM

Interactioni

Protein-protein interaction databases

BioGridi228047, 1 interactor
STRINGi10090.ENSMUSP00000083896

Structurei

3D structure databases

ProteinModelPortaliQ9D695
SMRiQ9D695
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ9D695
KOiK13964
OMAiYHGGISM
OrthoDBiEOG091G0ION
PhylomeDBiQ9D695
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D695-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLAAANAE FGFDLFREMD SSQGNGNVFF SSLSIFTALT LIRLGARGDC
60 70 80 90 100
ARQIDKALHF NIPSRQGNSS NNQPGLQYQL KRVLADINSS HKDYELSIAT
110 120 130 140 150
GVFAEKVYDF HKNYIECAEN LYNAKVERVD FTNDVQDTRF KINKWIENET
160 170 180 190 200
HGKIKKVLGD SSLSSSAVMV LVNAVYFKGK WKSAFTKTDT LSCRFRSPTC
210 220 230 240 250
PGKVVNMMHQ ERRFNLSTIQ QPPMQVLELQ YHGGISMYIM LPEDGLCEIE
260 270 280 290 300
SKLSFQNLMD WTNRRKMKSQ YVNVFLPQFK IEKNYEMTHH LKSLGLKDIF
310 320 330 340 350
DESSADLSGI ASGGRLYVSK LMHKSFIEVS EEGTEATAAT ENNIVEKQLP
360 370 380
ESTVFRADRP FLFVIKKNDI ILFTGKVSCP
Length:380
Mass (Da):43,050
Last modified:June 1, 2001 - v1
Checksum:iC9240272BCFB9CF4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2N5D3Z2N5_MOUSE
Serpin B7
Serpinb7
97Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105328 mRNA Translation: AAL16768.1
AK014524 mRNA Translation: BAB29410.1
CCDSiCCDS35686.1
RefSeqiNP_081824.1, NM_027548.3
UniGeneiMm.66015

Genome annotation databases

EnsembliENSMUST00000086690; ENSMUSP00000083896; ENSMUSG00000067001
GeneIDi116872
KEGGimmu:116872
UCSCiuc007chm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105328 mRNA Translation: AAL16768.1
AK014524 mRNA Translation: BAB29410.1
CCDSiCCDS35686.1
RefSeqiNP_081824.1, NM_027548.3
UniGeneiMm.66015

3D structure databases

ProteinModelPortaliQ9D695
SMRiQ9D695
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228047, 1 interactor
STRINGi10090.ENSMUSP00000083896

Protein family/group databases

MEROPSiI04.012

PTM databases

iPTMnetiQ9D695
PhosphoSitePlusiQ9D695

Proteomic databases

MaxQBiQ9D695
PaxDbiQ9D695
PRIDEiQ9D695

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086690; ENSMUSP00000083896; ENSMUSG00000067001
GeneIDi116872
KEGGimmu:116872
UCSCiuc007chm.2 mouse

Organism-specific databases

CTDi8710
MGIiMGI:2151053 Serpinb7

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ9D695
KOiK13964
OMAiYHGGISM
OrthoDBiEOG091G0ION
PhylomeDBiQ9D695
TreeFamiTF352619

Miscellaneous databases

PROiPR:Q9D695
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067001 Expressed in 43 organ(s), highest expression level in skin epidermis
ExpressionAtlasiQ9D695 baseline and differential
GenevisibleiQ9D695 MM

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPB7_MOUSE
AccessioniPrimary (citable) accession number: Q9D695
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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