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Protein

Protein transport protein Sec23B

Gene

Sec23b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61ZincBy similarity1
Metal bindingi66ZincBy similarity1
Metal bindingi85ZincBy similarity1
Metal bindingi88ZincBy similarity1

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • zinc ion binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23BCurated
Alternative name(s):
SEC23-related protein B
Gene namesi
Name:Sec23bImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1350925 Sec23b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002051492 – 767Protein transport protein Sec23BAdd BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei564N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D662
MaxQBiQ9D662
PaxDbiQ9D662
PRIDEiQ9D662

PTM databases

iPTMnetiQ9D662
PhosphoSitePlusiQ9D662
SwissPalmiQ9D662

Expressioni

Gene expression databases

BgeeiENSMUSG00000027429 Expressed in 291 organ(s), highest expression level in uterus
CleanExiMM_SEC23B
ExpressionAtlasiQ9D662 baseline and differential
GenevisibleiQ9D662 MM

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (By similarity). Interacts with SAR1A (By similarity).By similarity

Protein-protein interaction databases

BioGridi205109, 1 interactor
IntActiQ9D662, 2 interactors
MINTiQ9D662
STRINGi10090.ENSMUSP00000028916

Structurei

3D structure databases

ProteinModelPortaliQ9D662
SMRiQ9D662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati634 – 720Gelsolin-likeSequence analysisAdd BLAST87

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916
HOGENOMiHOG000231690
HOVERGENiHBG055039
InParanoidiQ9D662
KOiK14006
OMAiQFPPAYT
OrthoDBiEOG091G063R
PhylomeDBiQ9D662
TreeFamiTF300693

Family and domain databases

CDDicd11287 Sec23_C, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR037364 Sec23
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR037550 Sec23_C
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9D662-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPLAC LLTPLKERPD
60 70 80 90 100
LPPVQYEPVL CSRPTCKAIL NPLCQVDYRA KLWACNFCFQ RNQFPPAYAG
110 120 130 140 150
ISEVNQPAEL MPQFSTIEYM IQRGARSPLI FLYVVDTCLE EDDLQALKES
160 170 180 190 200
LQMSLSLLPP DALVGLITFG RMVQVHELSC EGISKSYVFR GTKDLTAKQI
210 220 230 240 250
QEMLGLTKSA MPVQQARPAQ PQEQPFVSSR FLQPIHKIDM NLTDLLGELQ
260 270 280 290 300
RDPWPVTQGK RPLRSTGVAL SIAVGLLEGT FPNTGARIML FTGGPPTQGP
310 320 330 340 350
GMVVGDELKT PIRSWHDIEK DNARFMKKAT KHYEMLANRT ATNGHCIDIY
360 370 380 390 400
ACALDQTGLL EMKCCPNLTG GHMVMGDSFN TSLFKQTFQR IFSKDFNGDF
410 420 430 440 450
RMAFGATLDV KTSRELKIAG AIGPCVSLNV KGPCVSENEL GVGGTSQWKI
460 470 480 490 500
CGLDPSSTLG IYFEVVNQHN APVPQGGRGA IQFVTQYQHS STQKRIRVTT
510 520 530 540 550
IARNWADAQS QLRHIEAAFD QEAAAVLMAR LGVFRAESEE GPDVLRWLDR
560 570 580 590 600
QLIRLCQKFG QYNKEDPTSF RLSDSFSLYP QFMFHLRRSP FLQVFNNSPD
610 620 630 640 650
ESSYYRHHFA RQDLTQSLIM IQPILYSYSF HGPPEPVLLD SSSILADRIL
660 670 680 690 700
LMDTFFQIVI YLGETIAQWR KAGYQDMPEY ENFKHLLQAP LDDAQEILQA
710 720 730 740 750
RFPMPRYINT EHGGSQARFL LSKVNPSQTH NNLYAWGQET GAPILTDDVS
760
LQVFMDHLKK LAVSSAS
Length:767
Mass (Da):86,437
Last modified:June 1, 2001 - v1
Checksum:i1CB8EAA252A93A97
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ANA0A2ANA0_MOUSE
Protein transport protein SEC23
Sec23b
278Annotation score:
A2AN98A2AN98_MOUSE
Protein transport protein SEC23
Sec23b
122Annotation score:
A2AN99A2AN99_MOUSE
Protein transport protein SEC23
Sec23b
138Annotation score:
A2AN97A2AN97_MOUSE
Protein transport protein SEC23
Sec23b
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti314S → W in AAF08301 (Ref. 1) Curated1
Sequence conflicti382 – 383SL → CV in AAF08301 (Ref. 1) Curated2
Sequence conflicti536A → T in AAH05464 (PubMed:15489334).Curated1
Sequence conflicti702F → L in AAF08301 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014597 mRNA Translation: BAB29452.1
AK149693 mRNA Translation: BAE29030.1
AK153214 mRNA Translation: BAE31812.1
AK166330 mRNA Translation: BAE38710.1
AF200326 mRNA Translation: AAF08301.1
AL808119 Genomic DNA No translation available.
BC005464 mRNA Translation: AAH05464.1
BC011160 mRNA Translation: AAH11160.1
CCDSiCCDS16822.1
RefSeqiNP_001239472.1, NM_001252543.1
NP_001239473.1, NM_001252544.1
NP_001239474.1, NM_001252545.1
NP_062761.2, NM_019787.4
XP_017174388.1, XM_017318899.1
UniGeneiMm.248492
Mm.487953

Genome annotation databases

EnsembliENSMUST00000028916; ENSMUSP00000028916; ENSMUSG00000027429
GeneIDi27054
KEGGimmu:27054
UCSCiuc008mrj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014597 mRNA Translation: BAB29452.1
AK149693 mRNA Translation: BAE29030.1
AK153214 mRNA Translation: BAE31812.1
AK166330 mRNA Translation: BAE38710.1
AF200326 mRNA Translation: AAF08301.1
AL808119 Genomic DNA No translation available.
BC005464 mRNA Translation: AAH05464.1
BC011160 mRNA Translation: AAH11160.1
CCDSiCCDS16822.1
RefSeqiNP_001239472.1, NM_001252543.1
NP_001239473.1, NM_001252544.1
NP_001239474.1, NM_001252545.1
NP_062761.2, NM_019787.4
XP_017174388.1, XM_017318899.1
UniGeneiMm.248492
Mm.487953

3D structure databases

ProteinModelPortaliQ9D662
SMRiQ9D662
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205109, 1 interactor
IntActiQ9D662, 2 interactors
MINTiQ9D662
STRINGi10090.ENSMUSP00000028916

PTM databases

iPTMnetiQ9D662
PhosphoSitePlusiQ9D662
SwissPalmiQ9D662

Proteomic databases

EPDiQ9D662
MaxQBiQ9D662
PaxDbiQ9D662
PRIDEiQ9D662

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028916; ENSMUSP00000028916; ENSMUSG00000027429
GeneIDi27054
KEGGimmu:27054
UCSCiuc008mrj.2 mouse

Organism-specific databases

CTDi10483
MGIiMGI:1350925 Sec23b

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916
HOGENOMiHOG000231690
HOVERGENiHBG055039
InParanoidiQ9D662
KOiK14006
OMAiQFPPAYT
OrthoDBiEOG091G063R
PhylomeDBiQ9D662
TreeFamiTF300693

Miscellaneous databases

ChiTaRSiSec23b mouse
PROiPR:Q9D662
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027429 Expressed in 291 organ(s), highest expression level in uterus
CleanExiMM_SEC23B
ExpressionAtlasiQ9D662 baseline and differential
GenevisibleiQ9D662 MM

Family and domain databases

CDDicd11287 Sec23_C, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR037364 Sec23
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR037550 Sec23_C
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC23B_MOUSE
AccessioniPrimary (citable) accession number: Q9D662
Secondary accession number(s): A2ANA1
, Q3U6B3, Q99K49, Q9QZ68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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