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Protein

Rab11 family-interacting protein 1

Gene

Rab11fip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and phagocytosis (By similarity).By similarity

GO - Molecular functioni

  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab11 family-interacting protein 1
Short name:
Rab11-FIP1
Alternative name(s):
Rab-coupling protein
Gene namesi
Name:Rab11fip1
Synonyms:Rcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1923017 Rab11fip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973051 – 645Rab11 family-interacting protein 1Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei208PhosphoserineBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei301PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei340PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei357PhosphoserineBy similarity1
Modified residuei358PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei434PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D620
MaxQBiQ9D620
PaxDbiQ9D620
PeptideAtlasiQ9D620
PRIDEiQ9D620

PTM databases

iPTMnetiQ9D620

Expressioni

Gene expression databases

BgeeiENSMUSG00000031488 Expressed in 134 organ(s), highest expression level in intestine
CleanExiMM_RAB11FIP1
ExpressionAtlasiQ9D620 baseline and differential
GenevisibleiQ9D620 MM

Interactioni

Subunit structurei

Homooligomer. Interacts with RAB4A, RAB11A, RAB11B and RAB25 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217725, 12 interactors
IntActiQ9D620, 13 interactors
MINTiQ9D620
STRINGi10090.ENSMUSP00000058042

Structurei

3D structure databases

ProteinModelPortaliQ9D620
SMRiQ9D620
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 110C2PROSITE-ProRule annotationAdd BLAST106
Domaini573 – 635FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni581 – 645Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recyclingBy similarityAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 220Poly-Lys10

Phylogenomic databases

eggNOGiENOG410IGQZ Eukaryota
ENOG410Z6B0 LUCA
GeneTreeiENSGT00530000063203
HOGENOMiHOG000234700
HOVERGENiHBG079127
InParanoidiQ9D620
KOiK12484

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037245 FIP-RBD_C_sf
IPR037789 FIP_classI
IPR019018 Rab-bd_FIP-RBD
PANTHERiPTHR15746 PTHR15746, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09457 RBD-FIP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51511 FIP_RBD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D620-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLAASAGRG PGTMWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE
60 70 80 90 100
KYATSVSERS LGAPVWREEA TFELPPLLSS GAAPAAAATL QLTVLHRALL
110 120 130 140 150
GLDKFLGRAE VDLRELHRDQ GRRKKQWYTL KSKPGKKDKE RGEIEVDIQF
160 170 180 190 200
MRNNMTASMF DLSMKDKSRN PFGKLKDKIK GKNKDSASDT ASAIVPSVTP
210 220 230 240 250
SVDSDDESFS KDKKKKSKIK TLFSKSSLQK TPLSQSMSVL PTSKSDKVLL
260 270 280 290 300
RAGDFQSQWD DDAHEDESSS ASDVMSHKRT SSTDQQPNQS NFSLPKKEGL
310 320 330 340 350
SFLGGLRSKN DSLSRSTVCI NGNHVYMEQP EARSEIRESS PSNSPSPQGF
360 370 380 390 400
RRKHLFSSTE NLAARSPKEP GEGGGTSSDR RLSDSSTKDS MKSMSLPSYR
410 420 430 440 450
PLTSGDNRES MSPANVEAAR ETKDSKKQES KKSSLLSLVT GKRDAAAKGS
460 470 480 490 500
ESEPLPTVSE KEKERKGALV EAQLREEDLM RRPEKDALPV ASQWGSSLNP
510 520 530 540 550
FEDVQISDPG ATTESRSEPK PPVPAARVPQ TKAVKPRPHP VKPMNTTATK
560 570 580 590 600
IANSSLGTAT IITENLISEA LMKKYQPSDP AFAYAQLTHD ELIQLVLKQK
610 620 630 640
ETISKKEFQV RELEDYIDNL LVRVMEETPN ILRVPAQMGK KAGKM
Length:645
Mass (Da):70,684
Last modified:July 27, 2011 - v2
Checksum:i667E0D12EC5FBD3B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q8L9E9Q8L9_MOUSE
Rab11 family-interacting protein 1
Rab11fip1
1,166Annotation score:
A0A1B0GRJ0A0A1B0GRJ0_MOUSE
Rab11 family-interacting protein 1
Rab11fip1
1,127Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60S → T in BAB29507 (PubMed:16141072).Curated1
Sequence conflicti207E → K in BAE30042 (PubMed:16141072).Curated1
Sequence conflicti256Q → H in BAE30042 (PubMed:16141072).Curated1
Sequence conflicti283T → A in BAE30042 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014696 mRNA Translation: BAB29507.1
AK151024 mRNA Translation: BAE30042.1
CH466580 Genomic DNA Translation: EDL32793.1
BC125400 mRNA Translation: AAI25401.1
BC132094 mRNA Translation: AAI32095.1
CCDSiCCDS52534.1
RefSeqiNP_083699.2, NM_029423.2
UniGeneiMm.205335

Genome annotation databases

EnsembliENSMUST00000033878; ENSMUSP00000033878; ENSMUSG00000031488
GeneIDi75767
KEGGimmu:75767
UCSCiuc009lia.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014696 mRNA Translation: BAB29507.1
AK151024 mRNA Translation: BAE30042.1
CH466580 Genomic DNA Translation: EDL32793.1
BC125400 mRNA Translation: AAI25401.1
BC132094 mRNA Translation: AAI32095.1
CCDSiCCDS52534.1
RefSeqiNP_083699.2, NM_029423.2
UniGeneiMm.205335

3D structure databases

ProteinModelPortaliQ9D620
SMRiQ9D620
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217725, 12 interactors
IntActiQ9D620, 13 interactors
MINTiQ9D620
STRINGi10090.ENSMUSP00000058042

PTM databases

iPTMnetiQ9D620

Proteomic databases

EPDiQ9D620
MaxQBiQ9D620
PaxDbiQ9D620
PeptideAtlasiQ9D620
PRIDEiQ9D620

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033878; ENSMUSP00000033878; ENSMUSG00000031488
GeneIDi75767
KEGGimmu:75767
UCSCiuc009lia.2 mouse

Organism-specific databases

CTDi80223
MGIiMGI:1923017 Rab11fip1

Phylogenomic databases

eggNOGiENOG410IGQZ Eukaryota
ENOG410Z6B0 LUCA
GeneTreeiENSGT00530000063203
HOGENOMiHOG000234700
HOVERGENiHBG079127
InParanoidiQ9D620
KOiK12484

Miscellaneous databases

ChiTaRSiRab11fip1 mouse
PROiPR:Q9D620
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031488 Expressed in 134 organ(s), highest expression level in intestine
CleanExiMM_RAB11FIP1
ExpressionAtlasiQ9D620 baseline and differential
GenevisibleiQ9D620 MM

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037245 FIP-RBD_C_sf
IPR037789 FIP_classI
IPR019018 Rab-bd_FIP-RBD
PANTHERiPTHR15746 PTHR15746, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09457 RBD-FIP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51511 FIP_RBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFIP1_MOUSE
AccessioniPrimary (citable) accession number: Q9D620
Secondary accession number(s): Q05A58, Q3UBC2, Q8BN24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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