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Protein

Kelch repeat and BTB domain-containing protein 12

Gene

Kbtbd12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 12
Alternative name(s):
Kelch domain-containing protein 6
Gene namesi
Name:Kbtbd12
Synonyms:Klhdc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1918481 Kbtbd12

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003247671 – 625Kelch repeat and BTB domain-containing protein 12Add BLAST625

Proteomic databases

PaxDbiQ9D618
PRIDEiQ9D618

PTM databases

iPTMnetiQ9D618
PhosphoSitePlusiQ9D618

Expressioni

Gene expression databases

BgeeiENSMUSG00000033182
CleanExiMM_KLHDC6
ExpressionAtlasiQ9D618 baseline and differential
GenevisibleiQ9D618 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132930

Structurei

3D structure databases

ProteinModelPortaliQ9D618
SMRiQ9D618
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 96BTBPROSITE-ProRule annotationAdd BLAST68
Domaini131 – 233BACKAdd BLAST103
Repeati384 – 434Kelch 1Add BLAST51
Repeati435 – 490Kelch 2Add BLAST56
Repeati492 – 545Kelch 3Add BLAST54
Repeati551 – 601Kelch 4Add BLAST51

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00910000143979
HOGENOMiHOG000113233
HOVERGENiHBG108066
InParanoidiQ9D618
KOiK21912
OMAiGGWTPQM
OrthoDBiEOG091G0L0D
TreeFamiTF351656

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR030583 KBTBD12
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF25 PTHR24412:SF25, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 4 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 4 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D618-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MECKTKGKHQ HSLNLLDKIK NMKELEEMID VVLIAEEEKF PCHRLVLAAF
60 70 80 90 100
SPYFKAMFTC GLLECTQREV ILYDITAESV SVILNYMYSA VLEINNANVQ
110 120 130 140 150
TVAMAAYFMQ MEEVFSVCQN YMMDHMDASN CIGIYYFAKQ IGAEDLSDQS
160 170 180 190 200
KKYLYQHFAE VSLHGEILDI EAHQLLALIK SDDLNISREE SILDLVLRWV
210 220 230 240 250
NHNQALRTEH LVELLKQVRL ELINASFLRQ ALRRNTMLLC DGSCIDIIQN
260 270 280 290 300
AFKAIKTPQQ HPSNLRYGME TTSLLLCIGN NSSGIRSRHR SYGDASFCYD
310 320 330 340 350
PVSHKTYFIS SPKYGEGLGT VCTGVVMENN TVIVAGEATA TRLSRQKSKN
360 370 380 390 400
IEIYRYHDRG NQFWEKLCTA EFRELYALGS IHNDLYVIGG QMKIKNQYLI
410 420 430 440 450
TNCVDKYSVD QDNWKRVSPL PLQLACHAVV TVNNKLYVIG GWTPQMDLPD
460 470 480 490 500
EEPDRLSNKL LQYDPSQDQW RERAPMRYSK YRFSAAVVNS EIYVLGGIGC
510 520 530 540 550
VGRDKGQVRK CLDVVEIYNP DGDFWREGPP MPSPLLSLRT NSTSAGAVDG
560 570 580 590 600
KLYVCGGFHG ADRHEVISKE ILELDPWENQ WNVVAINVLM HDSYDVCLVA
610 620
RMNPRDLIPP PSDLIEEDGD HRGQR
Length:625
Mass (Da):71,191
Last modified:July 27, 2011 - v3
Checksum:iE4AFA126721CB50F
GO
Isoform 2 (identifier: Q9D618-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-371: YHDRGNQFWEKLCTAE → CVSHSRFGIFCFVLLR
     372-625: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:371
Mass (Da):42,264
Checksum:i8FB6781161B1AE9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96N → Y in BAB29512 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032356356 – 371YHDRG…LCTAE → CVSHSRFGIFCFVLLR in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_032357372 – 625Missing in isoform 2. 1 PublicationAdd BLAST254

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014702 mRNA Translation: BAB29512.1
AC154038 Genomic DNA No translation available.
CCDSiCCDS51842.2 [Q9D618-1]
RefSeqiNP_001265600.1, NM_001278671.1 [Q9D618-1]
UniGeneiMm.196226

Genome annotation databases

EnsembliENSMUST00000120933; ENSMUSP00000112581; ENSMUSG00000033182 [Q9D618-1]
GeneIDi74589
KEGGimmu:74589
UCSCiuc009cvk.3 mouse [Q9D618-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKBTBC_MOUSE
AccessioniPrimary (citable) accession number: Q9D618
Secondary accession number(s): E9QJU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: February 28, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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