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Protein

DNA replication complex GINS protein PSF2

Gene

Gins2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA (By similarity).By similarity

GO - Biological processi

  • DNA duplex unwinding Source: GOC
  • DNA replication Source: UniProtKB-KW
  • double-strand break repair via break-induced replication Source: GO_Central

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-MMU-176974 Unwinding of DNA

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF2
Alternative name(s):
GINS complex subunit 2
Gene namesi
Name:Gins2
Synonyms:Psf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921019 Gins2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948141 – 185DNA replication complex GINS protein PSF2Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei180PhosphothreonineBy similarity1
Modified residuei182PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D600
MaxQBiQ9D600
PaxDbiQ9D600
PeptideAtlasiQ9D600
PRIDEiQ9D600

PTM databases

iPTMnetiQ9D600
PhosphoSitePlusiQ9D600

Expressioni

Gene expression databases

BgeeiENSMUSG00000031821 Expressed in 161 organ(s), highest expression level in heart
CleanExiMM_GINS2
GenevisibleiQ9D600 MM

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9D600, 1 interactor
MINTiQ9D600
STRINGi10090.ENSMUSP00000034278

Structurei

3D structure databases

ProteinModelPortaliQ9D600
SMRiQ9D600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GINS2/PSF2 family.Curated

Phylogenomic databases

eggNOGiKOG4071 Eukaryota
COG5093 LUCA
GeneTreeiENSGT00390000007838
HOGENOMiHOG000246603
HOVERGENiHBG044983
InParanoidiQ9D600
KOiK10733
OMAiIRMSKLR
OrthoDBiEOG091G0NTM
PhylomeDBiQ9D600
TreeFamiTF314359

Family and domain databases

InterProiView protein in InterPro
IPR021151 GINS_A
IPR036224 GINS_bundle-like_dom_sf
IPR007257 GINS_Psf2
PANTHERiPTHR12772 PTHR12772, 1 hit
PfamiView protein in Pfam
PF05916 Sld5, 1 hit
PIRSFiPIRSF028998 GINS_Psf2_subgr, 1 hit
SUPFAMiSSF158573 SSF158573, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D600-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAAEVEFLA EKELVTIIPN FSLDKIYLIG GDLGPFNPGL PVDVPLWLAI
60 70 80 90 100
NLKQRQKCRL LPPEWMDVEK LEQMRDEERK EETFTPVPSP HYMEITKLLL
110 120 130 140 150
NHASDNIPKA DTIRTLIKDL WDTRMAKLRV SADSFVRQQE AHAKLDNLTL
160 170 180
MEISSSGAFL TQALNHMYKL RTNLQPSEST QSQDF
Length:185
Mass (Da):21,236
Last modified:June 1, 2001 - v1
Checksum:i4DA756C71BD6EF1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28L → P in BAC25914 (PubMed:16141072).Curated1
Sequence conflicti148L → M in BAC25914 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014776 mRNA Translation: BAB29546.1
AK028375 mRNA Translation: BAC25914.1
AK030758 mRNA Translation: BAC27124.1
BC082565 mRNA Translation: AAH82565.1
CCDSiCCDS40496.1
RefSeqiNP_849187.1, NM_178856.1
UniGeneiMm.275910
Mm.334856

Genome annotation databases

EnsembliENSMUST00000034278; ENSMUSP00000034278; ENSMUSG00000031821
GeneIDi272551
KEGGimmu:272551
UCSCiuc009nrd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014776 mRNA Translation: BAB29546.1
AK028375 mRNA Translation: BAC25914.1
AK030758 mRNA Translation: BAC27124.1
BC082565 mRNA Translation: AAH82565.1
CCDSiCCDS40496.1
RefSeqiNP_849187.1, NM_178856.1
UniGeneiMm.275910
Mm.334856

3D structure databases

ProteinModelPortaliQ9D600
SMRiQ9D600
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D600, 1 interactor
MINTiQ9D600
STRINGi10090.ENSMUSP00000034278

PTM databases

iPTMnetiQ9D600
PhosphoSitePlusiQ9D600

Proteomic databases

EPDiQ9D600
MaxQBiQ9D600
PaxDbiQ9D600
PeptideAtlasiQ9D600
PRIDEiQ9D600

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034278; ENSMUSP00000034278; ENSMUSG00000031821
GeneIDi272551
KEGGimmu:272551
UCSCiuc009nrd.1 mouse

Organism-specific databases

CTDi51659
MGIiMGI:1921019 Gins2

Phylogenomic databases

eggNOGiKOG4071 Eukaryota
COG5093 LUCA
GeneTreeiENSGT00390000007838
HOGENOMiHOG000246603
HOVERGENiHBG044983
InParanoidiQ9D600
KOiK10733
OMAiIRMSKLR
OrthoDBiEOG091G0NTM
PhylomeDBiQ9D600
TreeFamiTF314359

Enzyme and pathway databases

ReactomeiR-MMU-176974 Unwinding of DNA

Miscellaneous databases

PROiPR:Q9D600
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031821 Expressed in 161 organ(s), highest expression level in heart
CleanExiMM_GINS2
GenevisibleiQ9D600 MM

Family and domain databases

InterProiView protein in InterPro
IPR021151 GINS_A
IPR036224 GINS_bundle-like_dom_sf
IPR007257 GINS_Psf2
PANTHERiPTHR12772 PTHR12772, 1 hit
PfamiView protein in Pfam
PF05916 Sld5, 1 hit
PIRSFiPIRSF028998 GINS_Psf2_subgr, 1 hit
SUPFAMiSSF158573 SSF158573, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSF2_MOUSE
AccessioniPrimary (citable) accession number: Q9D600
Secondary accession number(s): Q8BMT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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