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Protein

Keratin-associated protein 5-2

Gene

Krtap5-2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-2By similarity
Gene namesi
Name:Krtap5-2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918873 Krtap5-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003616581 – 189Keratin-associated protein 5-2Add BLAST189

Proteomic databases

PaxDbiQ9D5Z7
PRIDEiQ9D5Z7

PTM databases

PhosphoSitePlusiQ9D5Z7

Interactioni

Subunit structurei

Interacts with hair keratins.Curated

Structurei

3D structure databases

ProteinModelPortaliQ9D5Z7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 241Sequence analysis4
Repeati27 – 302Sequence analysis4
Repeati33 – 363Sequence analysis4
Repeati134 – 1374Sequence analysis4
Repeati144 – 1475Sequence analysis4
Repeati159 – 1626Sequence analysis4
Repeati169 – 1727Sequence analysis4
Repeati179 – 1828Sequence analysis4

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 1828 X 4 AA repeats of C-C-X-PSequence analysisAdd BLAST156

Sequence similaritiesi

Belongs to the KRTAP type 5 family.By similarity

Keywords - Domaini

Repeat

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 3 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D5Z7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCCGCSGGC GSSCGGCGSN CCKPVCCCKP VCCCVPACSC SSCGDCKGGC
60 70 80 90 100
GSCGGCKGGC GSCGGCKGGC GSCGGCKGGC GSCGGCGSCG GCKGGCSSCG
110 120 130 140 150
GCGSCGGCKG GCGSCGGCGS CGGCGSCGCC QSSCCKPCCC QSSCCKPCCC
160 170 180
QSSCCQSSCC KPCCCQSSCC KPCCCQSSCC APVCCQCKI
Length:189
Mass (Da):17,234
Last modified:June 1, 2001 - v1
Checksum:iB6A30BFB5E2AA31E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WRV2A0A087WRV2_MOUSE
Keratin-associated protein 5-2
Krtap5-2
367Annotation score:
E9QML2E9QML2_MOUSE
Keratin-associated protein 5-2
Krtap5-2
189Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014785 mRNA Translation: BAB29552.1
RefSeqiNP_082120.3, NM_027844.4
UniGeneiMm.293700

Genome annotation databases

GeneIDi71623
KEGGimmu:71623

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014785 mRNA Translation: BAB29552.1
RefSeqiNP_082120.3, NM_027844.4
UniGeneiMm.293700

3D structure databases

ProteinModelPortaliQ9D5Z7
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ9D5Z7

Proteomic databases

PaxDbiQ9D5Z7
PRIDEiQ9D5Z7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi71623
KEGGimmu:71623

Organism-specific databases

CTDi440021
MGIiMGI:1918873 Krtap5-2

Miscellaneous databases

PROiPR:Q9D5Z7
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 3 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKRA52_MOUSE
AccessioniPrimary (citable) accession number: Q9D5Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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