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Protein

Testis-expressed protein 19.2

Gene

Tex19.2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required during spermatogenesis, probably by participating in the repression of retrotransposable elements and prevent their mobilization (Probable). With its paralog, Tex19.1, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:28254886).1 Publication1 Publication

GO - Molecular functioni

  • piRNA binding Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • male gonad development Source: GO_Central
  • male meiotic nuclear division Source: UniProtKB
  • negative regulation of transposition Source: MGI
  • placenta development Source: GO_Central
  • spermatogenesis Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processDifferentiation, Meiosis, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed protein 19.2
Alternative name(s):
Testis-expressed protein 19B
Gene namesi
Name:Tex19.2
Synonyms:Tex19b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918206 Tex19.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Males deficient for both for Tex19.1 and Tex19.2 have impaired spermatogenesis, small testes and are infertile. They show vacuolization and seminiferous epithelium degeneration as early as P16. They have defects in meiotic chromosome synapsis, persistence of DNA double-strand breaks during meiosis, lack of post-meiotic germ cell and up-regulation of MMERVK10C retrotransproson expression. Number of females double knockout for Tex19.1 and Tex19.2 surviving 2 weeks or more is reduced compared to males. Females display normal fertility. Surviving mutants do not present gross somatic abnormalities.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003259641 – 317Testis-expressed protein 19.2Add BLAST317

Proteomic databases

PaxDbiQ9D5S1
PRIDEiQ9D5S1

Expressioni

Tissue specificityi

Specifically expressed in somatic cells of male gonad lineage.2 Publications

Developmental stagei

Expressed in the ectoderm and then in primordial germ cells (PGCs). Expressed in testis from embryonic day 13.5 (E13.5) to adulthood in gonocytes and spermatocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000039337 Expressed in 59 organ(s), highest expression level in testis
ExpressionAtlasiQ9D5S1 baseline and differential
GenevisibleiQ9D5S1 MM

Interactioni

Subunit structurei

Interacts with UBR2 (PubMed:21103378). Interacts with piRNA-associated proteins DDX4, EDC4, MAEL, PIWIL1, PIWIL2, RANBP9 and TDRD6 (Probable).1 Publication1 Publication

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni101 – 145Important for interaction with piRNA1 PublicationAdd BLAST45

Phylogenomic databases

eggNOGiENOG410IJA1 Eukaryota
ENOG41119UR LUCA
GeneTreeiENSGT00390000014279
HOGENOMiHOG000060232
HOVERGENiHBG095650
InParanoidiQ9D5S1
OMAiQDLHRWK
OrthoDBiEOG091G0TYV
PhylomeDBiQ9D5S1
TreeFamiTF338441

Family and domain databases

InterProiView protein in InterPro
IPR029093 TEX19
PANTHERiPTHR31387 PTHR31387, 1 hit
PfamiView protein in Pfam
PF15553 TEX19, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D5S1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCPPVSVRHG AKGMSCLYGA WLYHLVHGEQ MKICFACFKA AFLVVKNMLE
60 70 80 90 100
MGDWEEGVWD AEPMELSEAS SEPEEWPGLS GGEGQGHLPH GISVSAGSGA
110 120 130 140 150
QGPQPVPTEL GPQEAVPLDL GPEDAEWTQA LPWRFDGLSP CSHWLIPPLS
160 170 180 190 200
WWEIFNVSPS PGQPVLLELS PTWPMDPLEA EAWLVGLKFV FLLGGFDAIC
210 220 230 240 250
YMLSMTPCWA VRTRVQRWQV LLDPGDVRVA QLQNAPEQQD LHRWKLSVLE
260 270 280 290 300
SSELGMELVP ADCSLQKGGF KVHSYLPWHN STPESWSREP GERLLVVEVV
310
SLRELPCFRS PSPDPHN
Length:317
Mass (Da):35,235
Last modified:June 1, 2001 - v1
Checksum:i700FEDB9B80A7F3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014985 mRNA Translation: BAB29655.1
AL662887 Genomic DNA No translation available.
CCDSiCCDS25767.1
RefSeqiNP_081898.1, NM_027622.3
UniGeneiMm.158506

Genome annotation databases

EnsembliENSMUST00000039146; ENSMUSP00000037027; ENSMUSG00000039337
GeneIDi70956
KEGGimmu:70956
UCSCiuc007mvh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014985 mRNA Translation: BAB29655.1
AL662887 Genomic DNA No translation available.
CCDSiCCDS25767.1
RefSeqiNP_081898.1, NM_027622.3
UniGeneiMm.158506

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9D5S1
PRIDEiQ9D5S1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039146; ENSMUSP00000037027; ENSMUSG00000039337
GeneIDi70956
KEGGimmu:70956
UCSCiuc007mvh.2 mouse

Organism-specific databases

CTDi70956
MGIiMGI:1918206 Tex19.2

Phylogenomic databases

eggNOGiENOG410IJA1 Eukaryota
ENOG41119UR LUCA
GeneTreeiENSGT00390000014279
HOGENOMiHOG000060232
HOVERGENiHBG095650
InParanoidiQ9D5S1
OMAiQDLHRWK
OrthoDBiEOG091G0TYV
PhylomeDBiQ9D5S1
TreeFamiTF338441

Miscellaneous databases

PROiPR:Q9D5S1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039337 Expressed in 59 organ(s), highest expression level in testis
ExpressionAtlasiQ9D5S1 baseline and differential
GenevisibleiQ9D5S1 MM

Family and domain databases

InterProiView protein in InterPro
IPR029093 TEX19
PANTHERiPTHR31387 PTHR31387, 1 hit
PfamiView protein in Pfam
PF15553 TEX19, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTX19B_MOUSE
AccessioniPrimary (citable) accession number: Q9D5S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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