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Entry version 123 (16 Oct 2019)
Sequence version 1 (27 Apr 2001)
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Protein

Sedoheptulokinase

Gene

Shpk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a modulator of macrophage activation through control of glucose metabolism.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.19 mM for sedoheptulose1 Publication
  1. Vmax=0.128 nmol/min/mg enzyme (at 30 degrees Celsius)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.14 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-71336 Pentose phosphate pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sedoheptulokinase (EC:2.7.1.14)
Short name:
SHK
Alternative name(s):
Carbohydrate kinase-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shpk
Synonyms:Carkl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921887 Shpk

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi14T → M: Decreases sedoheptulose kinase activity; when associated with K-15. 1 Publication1
Mutagenesisi15T → K: Decreases sedoheptulose kinase activity; when associated with M-14. 1 Publication1
Mutagenesisi125W → D: Decreases sedoheptulose kinase activity. 1 Publication1
Mutagenesisi126Q → K: Decreases sedoheptulose kinase activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000595651 – 476SedoheptulokinaseAdd BLAST476

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9D5J6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9D5J6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9D5J6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9D5J6

PeptideAtlas

More...
PeptideAtlasi
Q9D5J6

PRoteomics IDEntifications database

More...
PRIDEi
Q9D5J6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9D5J6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9D5J6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by IL-4 and IL-13. Down-regulated by LPS.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005951 Expressed in 114 organ(s), highest expression level in colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9D5J6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9D5J6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000006105

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2517 Eukaryota
COG0554 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182753

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008078

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9D5J6

KEGG Orthology (KO)

More...
KOi
K11214

Identification of Orthologs from Complete Genome Data

More...
OMAi
SWNVEIL

Database of Orthologous Groups

More...
OrthoDBi
1027013at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9D5J6

TreeFam database of animal gene trees

More...
TreeFami
TF315140

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07777 FGGY_SHK_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018484 Carb_kinase_FGGY_N
IPR042027 SHK

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00370 FGGY_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D5J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRPVTLGI DLGTTSVKAA LLEAAPSLPS GFVVLASCAR AARAETESAV
60 70 80 90 100
AGPQGREQDV TRIIQALNEC LDALPRQQLQ RVRGIGVSGQ MHGILFWKAG
110 120 130 140 150
QGCEWMEGGP AFVFEPRAVS HLVTWQDGRC NSSFLASLPK PDSHLSVATG
160 170 180 190 200
FGCATIFWLL KNSPEFLKSY DAAGTIQDYV VAMLCGLPRP LMSDQNAASW
210 220 230 240 250
GYFNTQSQSW NLDTLEKAGF PIHLLPDIAE PGSMAGRTSH TWFEIPKGTQ
260 270 280 290 300
VGIALGDLQA SVYSCMGQRT DAVLNISTSV QLAASMPVGF QPLQTPDPAA
310 320 330 340 350
PVAFFPYFDR TYLGVAASLN GGNVLATFVH MLVQWMADLG LEVEESTVYS
360 370 380 390 400
RMIQAAAQQK DTHLTITPTV LGERHLPDQL ASVTRISSSD LSLGHVTRAL
410 420 430 440 450
CRGIVQNLHS MLPFQQLKEW GVARVVGSGS ALSRNEVLKQ EVQRAFPFPV
460 470
CFGQDVDAAF GAALVMLQRD LSQKEP
Length:476
Mass (Da):51,303
Last modified:April 27, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3638772519DBA3C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJM2D6RJM2_MOUSE
Sedoheptulokinase
Shpk
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK015273 mRNA Translation: BAB29776.1
AL663116 Genomic DNA No translation available.
AL670399 Genomic DNA No translation available.
BC054721 mRNA Translation: AAH54721.1
BC056433 mRNA Translation: AAH56433.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25002.1

NCBI Reference Sequences

More...
RefSeqi
NP_083307.1, NM_029031.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000006105; ENSMUSP00000006105; ENSMUSG00000005951

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
74637

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:74637

UCSC genome browser

More...
UCSCi
uc007kag.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015273 mRNA Translation: BAB29776.1
AL663116 Genomic DNA No translation available.
AL670399 Genomic DNA No translation available.
BC054721 mRNA Translation: AAH54721.1
BC056433 mRNA Translation: AAH56433.1
CCDSiCCDS25002.1
RefSeqiNP_083307.1, NM_029031.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006105

PTM databases

iPTMnetiQ9D5J6
PhosphoSitePlusiQ9D5J6

Proteomic databases

EPDiQ9D5J6
jPOSTiQ9D5J6
MaxQBiQ9D5J6
PaxDbiQ9D5J6
PeptideAtlasiQ9D5J6
PRIDEiQ9D5J6

Genome annotation databases

EnsembliENSMUST00000006105; ENSMUSP00000006105; ENSMUSG00000005951
GeneIDi74637
KEGGimmu:74637
UCSCiuc007kag.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23729
MGIiMGI:1921887 Shpk

Phylogenomic databases

eggNOGiKOG2517 Eukaryota
COG0554 LUCA
GeneTreeiENSGT00950000182753
HOGENOMiHOG000008078
InParanoidiQ9D5J6
KOiK11214
OMAiSWNVEIL
OrthoDBi1027013at2759
PhylomeDBiQ9D5J6
TreeFamiTF315140

Enzyme and pathway databases

BRENDAi2.7.1.14 3474
ReactomeiR-MMU-71336 Pentose phosphate pathway

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9D5J6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005951 Expressed in 114 organ(s), highest expression level in colon
ExpressionAtlasiQ9D5J6 baseline and differential
GenevisibleiQ9D5J6 MM

Family and domain databases

CDDicd07777 FGGY_SHK_like, 1 hit
InterProiView protein in InterPro
IPR018484 Carb_kinase_FGGY_N
IPR042027 SHK
PfamiView protein in Pfam
PF00370 FGGY_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHPK_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D5J6
Secondary accession number(s): Q5SSE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: October 16, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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