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Protein

Dynein regulatory complex subunit 3

Gene

Drc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex subunit 3
Alternative name(s):
Leucine-rich repeat-containing protein 48
Gene namesi
Name:Drc3
Synonyms:Lrrc48
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921915 Drc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277761 – 523Dynein regulatory complex subunit 3Add BLAST523

Proteomic databases

MaxQBiQ9D5E4
PaxDbiQ9D5E4
PRIDEiQ9D5E4

PTM databases

PhosphoSitePlusiQ9D5E4

Expressioni

Gene expression databases

BgeeiENSMUSG00000056598 Expressed in 144 organ(s), highest expression level in testis
CleanExiMM_LRRC48
ExpressionAtlasiQ9D5E4 baseline and differential
GenevisibleiQ9D5E4 MM

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC). Interacts with TCTE1/DRC5 (PubMed:28630322).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104363

Structurei

3D structure databases

ProteinModelPortaliQ9D5E4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 65LRR 1Add BLAST22
Repeati66 – 87LRR 2Add BLAST22
Repeati88 – 109LRR 3Add BLAST22
Repeati110 – 131LRR 4Add BLAST22
Repeati132 – 153LRR 5Add BLAST22
Domaini166 – 204LRRCTAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili204 – 242Sequence analysisAdd BLAST39
Coiled coili333 – 393Sequence analysisAdd BLAST61

Sequence similaritiesi

Belongs to the DRC3 family.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150857
HOGENOMiHOG000007647
HOVERGENiHBG079481
InParanoidiQ9D5E4
OMAiMRLEFKN
PhylomeDBiQ9D5E4
TreeFamiTF323974

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9D5E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRPYDSMEP KVMDDDMLKA AVGEQGPQEE AGQLAKQEGI LFKDVLSLQL
60 70 80 90 100
DFQNILRIDN LWQFENLKKL QLNNNIIERI EGLTNLIHLV WLDLSFNNIE
110 120 130 140 150
AIEGLDTLVN LEDLSLSNNR ISKVDSLDAL VKLQVLSLGN NQISNMMNII
160 170 180 190 200
YLRRFPCLRT LSLAGNPVSE AEEYKMFIYA YLSDLVYLDF RRVDEQMREM
210 220 230 240 250
AKMKHQYSID ELKHREAQLQ MKLEEEQAKQ EKLEEHKMAF VEHLNGPFLF
260 270 280 290 300
DSMYSEDVEG NKLSYLPGVR ELLEAYKDKF VIICLNIFEY GLNQQEKRKV
310 320 330 340 350
ELDTFNECIQ EAILENQDQG KLKVAKFEEK HLLNLNAIRE ETDLSNIEKK
360 370 380 390 400
LTECTESIGE LFNTLMILEM QLVEQLEETI NIFERNITDL VGLFIENVQS
410 420 430 440 450
LIAQCRDLEN HHHEKLLEIA INTLEKILKG EMDEDLPDDV RALFVDKDTI
460 470 480 490 500
VNAVGASHDI HLLKIDNRED ELVTGINSWC AHLVDKIHKD EIMRNRKRVK
510 520
EINQFVDHMQ SELDNLECGD IID
Length:523
Mass (Da):60,827
Last modified:June 1, 2001 - v1
Checksum:i1705D0EF302D30A8
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q537F6Q537_MOUSE
Dynein regulatory complex subunit 3
Drc3 Lrrc48
523Annotation score:
Q8BWX4Q8BWX4_MOUSE
Dynein regulatory complex subunit 3
Drc3 Lrrc48
278Annotation score:
Q5SX99Q5SX99_MOUSE
Dynein regulatory complex subunit 3
Drc3 Lrrc48
208Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015430 mRNA Translation: BAB29842.1
AL596090 Genomic DNA No translation available.
BC018412 mRNA Translation: AAH18412.1
CCDSiCCDS36172.1
RefSeqiNP_083320.1, NM_029044.2
UniGeneiMm.133570

Genome annotation databases

EnsembliENSMUST00000108723; ENSMUSP00000104363; ENSMUSG00000056598
GeneIDi74665
KEGGimmu:74665
UCSCiuc007jfu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015430 mRNA Translation: BAB29842.1
AL596090 Genomic DNA No translation available.
BC018412 mRNA Translation: AAH18412.1
CCDSiCCDS36172.1
RefSeqiNP_083320.1, NM_029044.2
UniGeneiMm.133570

3D structure databases

ProteinModelPortaliQ9D5E4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104363

PTM databases

PhosphoSitePlusiQ9D5E4

Proteomic databases

MaxQBiQ9D5E4
PaxDbiQ9D5E4
PRIDEiQ9D5E4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108723; ENSMUSP00000104363; ENSMUSG00000056598
GeneIDi74665
KEGGimmu:74665
UCSCiuc007jfu.1 mouse

Organism-specific databases

CTDi83450
MGIiMGI:1921915 Drc3

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150857
HOGENOMiHOG000007647
HOVERGENiHBG079481
InParanoidiQ9D5E4
OMAiMRLEFKN
PhylomeDBiQ9D5E4
TreeFamiTF323974

Miscellaneous databases

PROiPR:Q9D5E4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056598 Expressed in 144 organ(s), highest expression level in testis
CleanExiMM_LRRC48
ExpressionAtlasiQ9D5E4 baseline and differential
GenevisibleiQ9D5E4 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDRC3_MOUSE
AccessioniPrimary (citable) accession number: Q9D5E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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