Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UBX domain-containing protein 11

Gene

Ubxn11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 11
Alternative name(s):
Socius
UBX domain-containing protein 5
Gene namesi
Name:Ubxn11
Synonyms:D4Bwg1540e, Soc, Ubxd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914836 Ubxn11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849221 – 484UBX domain-containing protein 11Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei478PhosphoserineCombined sources1
Modified residuei482PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D572
PaxDbiQ9D572
PRIDEiQ9D572

PTM databases

iPTMnetiQ9D572
PhosphoSitePlusiQ9D572

Expressioni

Gene expression databases

BgeeiENSMUSG00000012126
ExpressionAtlasiQ9D572 baseline and differential
GenevisibleiQ9D572 MM

Interactioni

Subunit structurei

Interacts with GNA12, GNA13, RND1, RND2 AND RND3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074255

Structurei

3D structure databases

ProteinModelPortaliQ9D572
SMRiQ9D572
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini227 – 291SEPPROSITE-ProRule annotationAdd BLAST65
Domaini389 – 466UBXPROSITE-ProRule annotationAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili69 – 147Sequence analysisAdd BLAST79

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00390000010180
HOGENOMiHOG000154763
HOVERGENiHBG105985
InParanoidiQ9D572
OMAiRMTAEKF
OrthoDBiEOG091G02X6
PhylomeDBiQ9D572
TreeFamiTF329799

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D572-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPLASLSK TRKVPLESES VNPGRRGIRV YGNEDEVDMW NDGQDSEEKI
60 70 80 90 100
SLPSCYGGIG APVSRQGPHD SELMASMTRK LQELEQQLQA QNDEMLSKER
110 120 130 140 150
KILDLEDLVQ TLQQHQNNAA LQRQEELETQ CIQLQRQIGE MERFLSDYGL
160 170 180 190 200
QWVGEPMDQE NSEEKTVSEN DERDWMKAKK FWKPGDSFVP PEVDFDKLMA
210 220 230 240 250
SLQDLSELVE GEAQVTPVPG GARFRTLEPI PLKVYRNGIM MFDGPFRPFY
260 270 280 290 300
DPSTQRCLRD ILDGFFPSEL QRLYPDGVPF KVSDLRNQIY PEDGLGQFPG
310 320 330 340 350
EGRVVGRQKM RKVTDRVEET SGSRMTAEQF LNRLPKCIIR QGEVIDIRGP
360 370 380 390 400
IRDTLQNCCP MPARIQEIIV ETPALASERQ RSQESPDMPM PLLSMLRIKS
410 420 430 440 450
ENGEQAFLLM MWPEDTIGDV RKLLAQARDM DSAAFEILST FPPTVYQDDT
460 470 480
VTLQAAGLVP NATLLLRTRR ALLSNPISRP GSLP
Length:484
Mass (Da):54,875
Last modified:June 1, 2001 - v1
Checksum:i03289562FDD928F8
GO
Isoform 2 (identifier: Q9D572-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-284: VSD → APG
     285-484: Missing.

Show »
Length:284
Mass (Da):32,402
Checksum:i9516A5476D41773E
GO

Sequence cautioni

The sequence BAB26982 differs from that shown. Reason: Frameshift at positions 191, 395 and 454.Curated
The sequence BAC33351 differs from that shown. Reason: Frameshift at position 63.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151Q → R in BAB26982 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024778282 – 284VSD → APG in isoform 2. 1 Publication3
Alternative sequenceiVSP_024779285 – 484Missing in isoform 2. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010492 mRNA Translation: BAB26982.1 Frameshift.
AK015720 mRNA Translation: BAB29947.1
AK048494 mRNA Translation: BAC33351.1 Frameshift.
AL670680 Genomic DNA No translation available.
BC019461 mRNA Translation: AAH19461.1
CCDSiCCDS18763.1 [Q9D572-1]
RefSeqiNP_080533.1, NM_026257.3 [Q9D572-1]
UniGeneiMm.282029

Genome annotation databases

EnsembliENSMUST00000074690; ENSMUSP00000074255; ENSMUSG00000012126 [Q9D572-1]
GeneIDi67586
KEGGimmu:67586
UCSCiuc008veb.2 mouse [Q9D572-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUBX11_MOUSE
AccessioniPrimary (citable) accession number: Q9D572
Secondary accession number(s): Q8C843, Q8VCP5, Q9CWP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health