UniProtKB - Q9D563 (TM114_MOUSE)
Protein
Transmembrane protein 114
Gene
Tmem114
Organism
Mus musculus (Mouse)
Status
Functioni
Protein family/group databases
TCDBi | 8.A.16.2.7, the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 114By similarityAlternative name(s): Claudin-26 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921970, Tmem114 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: N-glycosylation at Asn-54 and Asn-88 is required for plasma membrane localization.
Plasma Membrane
- apical plasma membrane Source: MGI
- apicolateral plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 133 – 153 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 188 – 208 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 54 | N → K: Complete loss of glycosylation; when associated with K-88. 1 Publication | 1 | |
Mutagenesisi | 88 | N → K: Complete loss of glycosylation; when associated with K-54. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000352760 | 1 – 222 | Transmembrane protein 114Add BLAST | 222 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 54 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 88 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9D563 |
PRIDEi | Q9D563 |
ProteomicsDBi | 259211 |
PTM databases
GlyGeni | Q9D563, 2 sites |
iPTMneti | Q9D563 |
PhosphoSitePlusi | Q9D563 |
Expressioni
Developmental stagei
Expressed weakly in the eye from as early as 13.5 dpc, with ocular expression up-regulated postnatally. By 10 weeks, expressed strongly in the lens epithelial cells and weakly in lens fibers. In adult, expressed in eye, brain and testis.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000022715, Expressed in testis and 52 other tissues |
Genevisiblei | Q9D563, MM |
Interactioni
Protein-protein interaction databases
IntActi | Q9D563, 1 interactor |
MINTi | Q9D563 |
STRINGi | 10090.ENSMUSP00000023400 |
Miscellaneous databases
RNActi | Q9D563, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QR97, Eukaryota |
GeneTreei | ENSGT00390000011615 |
HOGENOMi | CLU_102991_0_0_1 |
InParanoidi | Q9D563 |
OMAi | CYPLINP |
OrthoDBi | 1265742at2759 |
PhylomeDBi | Q9D563 |
TreeFami | TF327980 |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR039951, TMEM114/TMEM235 |
PANTHERi | PTHR20516, PTHR20516, 1 hit |
Pfami | View protein in Pfam PF13903, Claudin_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9D563-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRVRLGALAG AAALSGALSF VLLAAAIGTD FWYIIDTERL ERSSQRMRDQ
60 70 80 90 100
GPANRSQQEP LSSHSGLWRT CRVQSSCTPL MNPFWQENVT VSDSSRQLLT
110 120 130 140 150
MHGTFVILLP LSLIVMVFGG MTGFLSFLLR AHLLLLLTGI LFLFGAMVTL
160 170 180 190 200
TGISIYIAYS AVAFREAVCL LEERALLDQV DIRFGWSLAL GWISFVSELL
210 220
TGVVFLAAAR ALSLSQRQDQ AI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK015757 mRNA Translation: BAB29961.1 CH466521 Genomic DNA Translation: EDK97288.1 BC027071 mRNA Translation: AAH27071.1 BC147190 mRNA Translation: AAI47191.1 BC147191 mRNA Translation: AAI47192.1 |
CCDSi | CCDS27937.1 |
RefSeqi | NP_083346.1, NM_029070.2 |
Genome annotation databases
Ensembli | ENSMUST00000023400; ENSMUSP00000023400; ENSMUSG00000022715 |
GeneIDi | 74720 |
KEGGi | mmu:74720 |
UCSCi | uc007yck.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK015757 mRNA Translation: BAB29961.1 CH466521 Genomic DNA Translation: EDK97288.1 BC027071 mRNA Translation: AAH27071.1 BC147190 mRNA Translation: AAI47191.1 BC147191 mRNA Translation: AAI47192.1 |
CCDSi | CCDS27937.1 |
RefSeqi | NP_083346.1, NM_029070.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9D563, 1 interactor |
MINTi | Q9D563 |
STRINGi | 10090.ENSMUSP00000023400 |
Protein family/group databases
TCDBi | 8.A.16.2.7, the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family |
PTM databases
GlyGeni | Q9D563, 2 sites |
iPTMneti | Q9D563 |
PhosphoSitePlusi | Q9D563 |
Proteomic databases
PaxDbi | Q9D563 |
PRIDEi | Q9D563 |
ProteomicsDBi | 259211 |
Protocols and materials databases
Antibodypediai | 51871, 13 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000023400; ENSMUSP00000023400; ENSMUSG00000022715 |
GeneIDi | 74720 |
KEGGi | mmu:74720 |
UCSCi | uc007yck.1, mouse |
Organism-specific databases
CTDi | 283953 |
MGIi | MGI:1921970, Tmem114 |
Phylogenomic databases
eggNOGi | ENOG502QR97, Eukaryota |
GeneTreei | ENSGT00390000011615 |
HOGENOMi | CLU_102991_0_0_1 |
InParanoidi | Q9D563 |
OMAi | CYPLINP |
OrthoDBi | 1265742at2759 |
PhylomeDBi | Q9D563 |
TreeFami | TF327980 |
Miscellaneous databases
BioGRID-ORCSi | 74720, 2 hits in 52 CRISPR screens |
ChiTaRSi | Tmem114, mouse |
PROi | PR:Q9D563 |
RNActi | Q9D563, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022715, Expressed in testis and 52 other tissues |
Genevisiblei | Q9D563, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR039951, TMEM114/TMEM235 |
PANTHERi | PTHR20516, PTHR20516, 1 hit |
Pfami | View protein in Pfam PF13903, Claudin_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM114_MOUSE | |
Accessioni | Q9D563Primary (citable) accession number: Q9D563 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 14, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot