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Protein

Meiosis inhibitor protein 1

Gene

Mei1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes.2 Publications

GO - Biological processi

  • gamete generation Source: MGI
  • male meiosis I Source: MGI
  • meiotic cell cycle Source: MGI
  • meiotic telomere clustering Source: MGI
  • spermatid development Source: MGI

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis inhibitor protein 1
Alternative name(s):
Meiosis defective protein 1
Gene namesi
Name:Mei1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3028590 Mei1

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

Mice are infertile due to meiotic arrest caused by defects in chromosome synapsis. They lack zygotene Rad51 foci, and are likely to be deficient in meiotic double-strand break (DSB) formation. In addition, mutant spermatocytes exhibit meiotic arrest at entry into pachynema, whereas oocytes progress to an abnormal metaphase I.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003472651 – 1268Meiosis inhibitor protein 1Add BLAST1268

Proteomic databases

PaxDbiQ9D4I2
PRIDEiQ9D4I2

PTM databases

iPTMnetiQ9D4I2
PhosphoSitePlusiQ9D4I2

Expressioni

Tissue specificityi

Strongly expressed in testis, weakly in brain, and not detected in spleen, liver, kidney, small intestine or colon.1 Publication

Developmental stagei

Highly expressed in E17 ovaries. Expression is significantly reduced in newborn ovaries, and is undetectable in ovaries from 5 day and 8 week old mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000068117 Expressed in 26 organ(s), highest expression level in utricle of membranous labyrinth
ExpressionAtlasiQ9D4I2 baseline and differential
GenevisibleiQ9D4I2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086582

Structurei

3D structure databases

ProteinModelPortaliQ9D4I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IDYP Eukaryota
ENOG410Y5J6 LUCA
GeneTreeiENSGT00390000002077
HOGENOMiHOG000113556
HOVERGENiHBG108129
InParanoidiQ9D4I2
OrthoDBiEOG091G00RU
PhylomeDBiQ9D4I2
TreeFamiTF336500

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D4I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAADHPAFG RDEEAALLLE RTHHRHDPRW LLPVSPHVCM ACALELLPEP
60 70 80 90 100
GVSLVRKKHV VFCFQDALVR HTSLVAQLVA QDQRVCIHFV RVLFGLLNSV
110 120 130 140 150
EDGSMADLCI EVLVQLTTQP NMEQTIRCLM NECHRELCNL RSMGGSLATT
160 170 180 190 200
TLLGKLVDTI PGLADELVME HGNLMEHLLR GLVYPNEGVQ ASICYLYGKL
210 220 230 240 250
YSSPTAAEML SGHFREKLCA LFLSTLDSAQ TKDLQINCLG LLRQLLKYDL
260 270 280 290 300
FVSLIMNKSV PVEGAESVER PSRETSLPLV LKKFLLSRDE ILQVASSHCI
310 320 330 340 350
TAVLVHSPAK HAVAFIHADI PEFLFEHLSS SSEILVWSSY NCLILLAEEP
360 370 380 390 400
LFFSKCHTVY GIEAVVRSLQ GSQQMTNTEL HTQGLLLFKE ILTRQPEEIR
410 420 430 440 450
LFTSSALCRD ASRALQEAVS SPVLAVAAEA LRAISAFLRK DHQSSLPVQY
460 470 480 490 500
RALRALLEAM LSRCMEFSQT PLNRRSLGHA CSRNSEKATL RKGSFLLSTL
510 520 530 540 550
EGFRNACRLA VEFQGEPSAQ ENPFTAPSAE KEDTLEAFSE YLLSACDSQC
560 570 580 590 600
IPMVMRYSEE ATHPKLMEVF LSILHSLFVI IPHMKVKFSR KLADSSFIRL
610 620 630 640 650
TLELKARFCS GQSHSSLNQV CSSFLYYMCL NLLSAPEKTE PLSQEELSAV
660 670 680 690 700
SEFLQHGLPH ISSRTPESLA FLSDRQYVEA ATRQRQYCIL LLFYLAHIHD
710 720 730 740 750
DRFVPEAELF VAVQSFLLSL QDQGECPPPV VCKASMYLLA VCGDKDSALA
760 770 780 790 800
EAVISAIRKF LEGIPDLRGV YTHHPLLLRF FLAYPGLMSR FGHRVLELWF
810 820 830 840 850
SWEESGYENL DDDSSPGRTV FPANLAALFR VLQSTPSILL ILLDLVYSSP
860 870 880 890 900
VDTARKVLIV LRVFLWENED VKVGGLIRGH FLLILQRLLV EYGASTSGGN
910 920 930 940 950
LPLLLNLLSL VQMRNESEQE LDSMAMKLLH QVSMLCGKCS PAHVDILQPS
960 970 980 990 1000
FNFLYWSLHQ TTPSSQKRAA AVLLSSTALL ELLEKMLALT WTETGSSPRT
1010 1020 1030 1040 1050
PLLSSAWLLT ASFSAQQHNG NLQVHRTLSV ELNQVLKALS FPKKMSALLS
1060 1070 1080 1090 1100
AAILRFLRTA LQQSFSSALV VLVPSGDQPL STPEDAVLAP LGKSQVLALL
1110 1120 1130 1140 1150
IGLQNLLVQK DPLLSQACIG CLEALLDYLH ARSPDIALHV ASQPWNRFLL
1160 1170 1180 1190 1200
FTLLDAGENS FLRPEILRLM TLFVQYRSSC VLSREEVGLI LQGAALVDLS
1210 1220 1230 1240 1250
ALSNDTLQAL HGFLLQVQSM GLLNDQHMTQ TLQSSLEGLC SRTFPAQPLF
1260
QDMLCLGGVS VSQAHIRG
Note: No experimental confirmation available.Curated
Length:1,268
Mass (Da):140,874
Last modified:December 20, 2017 - v4
Checksum:i4A63F758A69CE22D
GO
Isoform 22 Publications (identifier: Q9D4I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-374: Missing.

Show »
Length:894
Mass (Da):99,260
Checksum:iF53077560F364E87
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQR2A0A087WQR2_MOUSE
Meiosis inhibitor protein 1
Mei1
244Annotation score:
A0A2R8VHD2A0A2R8VHD2_MOUSE
Meiosis inhibitor protein 1
Mei1
1,324Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti680A → V in AAI37750 (PubMed:15489334).Curated1
Sequence conflicti863V → A in AAI37750 (PubMed:15489334).Curated1
Sequence conflicti866W → R in AAI37750 (PubMed:15489334).Curated1
Sequence conflicti894A → S in AAI37750 (PubMed:15489334).Curated1
Sequence conflicti1199L → R in AAI37750 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0528921 – 374Missing in isoform 2. 3 PublicationsAdd BLAST374

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY270177 mRNA Translation: AAP74551.1
AK016514 mRNA Translation: BAB30279.2
AC102176 Genomic DNA No translation available.
BC137749 mRNA Translation: AAI37750.1
CCDSiCCDS79396.1 [Q9D4I2-2]
RefSeqiNP_001297364.1, NM_001310435.1 [Q9D4I2-2]
NP_083173.2, NM_028897.3 [Q9D4I2-1]
UniGeneiMm.289351

Genome annotation databases

EnsembliENSMUST00000089178; ENSMUSP00000086582; ENSMUSG00000068117 [Q9D4I2-1]
ENSMUST00000188048; ENSMUSP00000139689; ENSMUSG00000068117 [Q9D4I2-2]
ENSMUST00000189540; ENSMUSP00000140479; ENSMUSG00000068117 [Q9D4I2-2]
GeneIDi74369
KEGGimmu:74369
UCSCiuc007wyd.2 mouse [Q9D4I2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY270177 mRNA Translation: AAP74551.1
AK016514 mRNA Translation: BAB30279.2
AC102176 Genomic DNA No translation available.
BC137749 mRNA Translation: AAI37750.1
CCDSiCCDS79396.1 [Q9D4I2-2]
RefSeqiNP_001297364.1, NM_001310435.1 [Q9D4I2-2]
NP_083173.2, NM_028897.3 [Q9D4I2-1]
UniGeneiMm.289351

3D structure databases

ProteinModelPortaliQ9D4I2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086582

PTM databases

iPTMnetiQ9D4I2
PhosphoSitePlusiQ9D4I2

Proteomic databases

PaxDbiQ9D4I2
PRIDEiQ9D4I2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089178; ENSMUSP00000086582; ENSMUSG00000068117 [Q9D4I2-1]
ENSMUST00000188048; ENSMUSP00000139689; ENSMUSG00000068117 [Q9D4I2-2]
ENSMUST00000189540; ENSMUSP00000140479; ENSMUSG00000068117 [Q9D4I2-2]
GeneIDi74369
KEGGimmu:74369
UCSCiuc007wyd.2 mouse [Q9D4I2-2]

Organism-specific databases

CTDi150365
MGIiMGI:3028590 Mei1

Phylogenomic databases

eggNOGiENOG410IDYP Eukaryota
ENOG410Y5J6 LUCA
GeneTreeiENSGT00390000002077
HOGENOMiHOG000113556
HOVERGENiHBG108129
InParanoidiQ9D4I2
OrthoDBiEOG091G00RU
PhylomeDBiQ9D4I2
TreeFamiTF336500

Miscellaneous databases

PROiPR:Q9D4I2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068117 Expressed in 26 organ(s), highest expression level in utricle of membranous labyrinth
ExpressionAtlasiQ9D4I2 baseline and differential
GenevisibleiQ9D4I2 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMEII1_MOUSE
AccessioniPrimary (citable) accession number: Q9D4I2
Secondary accession number(s): B2RQ44, F8WHB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 20, 2017
Last modified: November 7, 2018
This is version 108 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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