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Protein

GRIP and coiled-coil domain-containing protein 1

Gene

Gcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in maintaining Golgi structure.By similarity

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein 1
Alternative name(s):
Golgi coiled-coil protein 1
Gene namesi
Name:Gcc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1921625 Gcc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900731 – 778GRIP and coiled-coil domain-containing protein 1Add BLAST778

Proteomic databases

EPDiQ9D4H2
MaxQBiQ9D4H2
PaxDbiQ9D4H2
PeptideAtlasiQ9D4H2
PRIDEiQ9D4H2

PTM databases

iPTMnetiQ9D4H2
PhosphoSitePlusiQ9D4H2

Expressioni

Gene expression databases

BgeeiENSMUSG00000029708 Expressed in 247 organ(s), highest expression level in cochlea
CleanExiMM_GCC1
ExpressionAtlasiQ9D4H2 baseline and differential
GenevisibleiQ9D4H2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067395

Structurei

3D structure databases

ProteinModelPortaliQ9D4H2
SMRiQ9D4H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini716 – 766GRIPPROSITE-ProRule annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 61Sequence analysisAdd BLAST49
Coiled coili152 – 702Sequence analysisAdd BLAST551

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEHR Eukaryota
ENOG410Y6HA LUCA
GeneTreeiENSGT00440000039893
HOGENOMiHOG000252925
HOVERGENiHBG039459
InParanoidiQ9D4H2
KOiK20281
OMAiAEDWKQE
OrthoDBiEOG091G0R8Q
PhylomeDBiQ9D4H2
TreeFamiTF324186

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D4H2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE
60 70 80 90 100
ALEASIKVLS VSHEADVGLS GVQPPGLTFP DSVDDRCSTH SEDSTGTATS
110 120 130 140 150
LDTAASLTSV KGEFGVEDDR AARGPLPPKS EEASGSESGV SSSSGDGPSA
160 170 180 190 200
GSEMDKRVHQ LKTQLATLTS SLATVTQEKS RMEASYLADK KKMKQDLEDA
210 220 230 240 250
NKKAEEERGR LEGDLKVLQE QIAETKARLI TQQHDRAQEQ SDHALMLREL
260 270 280 290 300
QKLLQEERTQ RQDLELRLEE TREALAGRAY AADQVEGFEL QTKQLTREVE
310 320 330 340 350
ELKGELQTIR DEKNRPDPRL QELQQEAARL KSHFQAQLQQ EMRKTALAED
360 370 380 390 400
QLRQQSQVEE QRVAALESQI SEVSELLGTY EKAKQKDQLA IQKLKERLLQ
410 420 430 440 450
LDLENKTLAL AASSRSSLDI HGDESSLDIN VLKDKMEKLK KLLQVAARKS
460 470 480 490 500
QVTLDVEKLC DPEIMANSEA ADGEKATALY YQQELKQLKE EFERYKMRAQ
510 520 530 540 550
VVLKSKNTKD GSLGKELEAA QEQLAELKDK YISLRLSCEE LESQHQQEAE
560 570 580 590 600
DWKQELARLQ QLHRQELERS QLDFRDRTLK LEEELHKQRD RALAVLAEKD
610 620 630 640 650
LELEQLRSVA LSSGLPGRRS PVGGVGGGGL GDPADTASSD SLTQALQLAA
660 670 680 690 700
ANEPTFFLYA EQLARKEVEI TSLRKQKHRL EVEAHQLQER LLEEGERHRE
710 720 730 740 750
EVGALQSHIE KNMRDQSREG ANLEYLKNII YRFLTLPDSL GRQQTLTAIL
760 770
TILHFSPEEK QVLMRLPSGG SWWPSGKR
Length:778
Mass (Da):87,678
Last modified:July 11, 2003 - v2
Checksum:i10443331CB480A2B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VDD7F6VDD7_MOUSE
GRIP and coiled-coil domain-contain...
Gcc1
194Annotation score:
E9Q6U7E9Q6U7_MOUSE
GRIP and coiled-coil domain-contain...
Gcc1
12Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti456V → M in BAC27780 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032253 mRNA Translation: BAC27780.1
BC066807 mRNA Translation: AAH66807.1
CCDSiCCDS19951.1
RefSeqiNP_083176.3, NM_028900.4
UniGeneiMm.332950

Genome annotation databases

EnsembliENSMUST00000064377; ENSMUSP00000067395; ENSMUSG00000029708
ENSMUST00000090511; ENSMUSP00000087997; ENSMUSG00000029708
GeneIDi74375
KEGGimmu:74375
UCSCiuc009bco.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032253 mRNA Translation: BAC27780.1
BC066807 mRNA Translation: AAH66807.1
CCDSiCCDS19951.1
RefSeqiNP_083176.3, NM_028900.4
UniGeneiMm.332950

3D structure databases

ProteinModelPortaliQ9D4H2
SMRiQ9D4H2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067395

PTM databases

iPTMnetiQ9D4H2
PhosphoSitePlusiQ9D4H2

Proteomic databases

EPDiQ9D4H2
MaxQBiQ9D4H2
PaxDbiQ9D4H2
PeptideAtlasiQ9D4H2
PRIDEiQ9D4H2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064377; ENSMUSP00000067395; ENSMUSG00000029708
ENSMUST00000090511; ENSMUSP00000087997; ENSMUSG00000029708
GeneIDi74375
KEGGimmu:74375
UCSCiuc009bco.2 mouse

Organism-specific databases

CTDi79571
MGIiMGI:1921625 Gcc1

Phylogenomic databases

eggNOGiENOG410IEHR Eukaryota
ENOG410Y6HA LUCA
GeneTreeiENSGT00440000039893
HOGENOMiHOG000252925
HOVERGENiHBG039459
InParanoidiQ9D4H2
KOiK20281
OMAiAEDWKQE
OrthoDBiEOG091G0R8Q
PhylomeDBiQ9D4H2
TreeFamiTF324186

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiGcc1 mouse
PROiPR:Q9D4H2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029708 Expressed in 247 organ(s), highest expression level in cochlea
CleanExiMM_GCC1
ExpressionAtlasiQ9D4H2 baseline and differential
GenevisibleiQ9D4H2 MM

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCC1_MOUSE
AccessioniPrimary (citable) accession number: Q9D4H2
Secondary accession number(s): Q8CCR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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