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Protein

Exocyst complex component 2

Gene

Exoc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

  • protein kinase binding Source: MGI
  • protein N-terminus binding Source: UniProtKB
  • Ral GTPase binding Source: MGI

GO - Biological processi

  • exocyst assembly Source: GO_Central
  • Golgi to plasma membrane transport Source: InterPro
  • positive regulation of exocytosis Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of entry of bacterium into host cell Source: MGI

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 2
Alternative name(s):
Exocyst complex component Sec5
Gene namesi
Name:Exoc2
Synonyms:Sec5, Sec5l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913732 Exoc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189191 – 924Exocyst complex component 2Add BLAST924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei431PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei435PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1
Modified residuei454N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D4H1
MaxQBiQ9D4H1
PaxDbiQ9D4H1
PeptideAtlasiQ9D4H1
PRIDEiQ9D4H1

PTM databases

iPTMnetiQ9D4H1
PhosphoSitePlusiQ9D4H1

Expressioni

Gene expression databases

BgeeiENSMUSG00000021357 Expressed in 245 organ(s), highest expression level in bone marrow
CleanExiMM_EXOC2
GenevisibleiQ9D4H1 MM

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1. Interacts with GNEFR/DELGEF; this interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (PubMed:18480549). Interacts with GNEFR/DELGEF. Interaction with GNEFR occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (By similarity). Interacts with RALA and RALB (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211506, 2 interactors
IntActiQ9D4H1, 2 interactors
MINTiQ9D4H1
STRINGi10090.ENSMUSP00000021785

Structurei

Secondary structure

1924
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9D4H1
SMRiQ9D4H1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D4H1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 93IPT/TIGAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili240 – 260Sequence analysisAdd BLAST21

Domaini

Interacts with RALA through the TIG domain.

Sequence similaritiesi

Belongs to the SEC5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2347 Eukaryota
ENOG410XSY3 LUCA
GeneTreeiENSGT00390000010872
HOGENOMiHOG000044231
HOVERGENiHBG028469
InParanoidiQ9D4H1
KOiK17637
OMAiEWKSPNK
OrthoDBiEOG091G02P6
PhylomeDBiQ9D4H1
TreeFamiTF105891

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR029175 EXOC2/Sec5
IPR039481 EXOC2/Sec5_N_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
PANTHERiPTHR13043 PTHR13043, 1 hit
PfamiView protein in Pfam
PF15469 Sec5, 1 hit
PF01833 TIG, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D4H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPTDLIG LTICGHNCLL
60 70 80 90 100
TAEWMSASKI VCRVGQAKND KGDIIVTTKS GGKGTSTVSF KLLKPEKIGI
110 120 130 140 150
LDQSAVWVDE MNYYDMRTDR NKGIPPLSLR PANPLGIEIE KCKLPQKNLE
160 170 180 190 200
VLFHGMSADF TSENFSAAWY LIENHSTTSF EQLKMAVTNL KRQANKKSEG
210 220 230 240 250
SLAYVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ KLENVLNRAS
260 270 280 290 300
NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI KRNIQKGDYD
310 320 330 340 350
VVINDYEKAK SLFGKTEVQV FKKYYAEVEA GIEDLRELLL KKLLETPSTL
360 370 380 390 400
HDQKRYIRYL SDLHAPGDPA WQCIGAQHKW TLKLMQDCKE GHMKSLKGHP
410 420 430 440 450
GPHSPMLDLD NDVRPSVLGH LSQTASLKRG SSFQSGRDDT WRYKTPHRVA
460 470 480 490 500
FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS ETAEKSGQSE RSKNVRQRQN
510 520 530 540 550
DFKKMIQEVM HSLVKLIRGA LLPLSLREGD GRQYGGWEVQ AELSGQWLAH
560 570 580 590 600
VIQTIRLTYE SLTALEIPND MLQIIQDLIL DLRIRCIMVT LQHTAEEIKR
610 620 630 640 650
LAEKEDWVVD NEGLTSLPCQ FEQSIVHSLQ SLKGVVDCKP GEASVFQQPK
660 670 680 690 700
TQEEVCQLCI NIMQVFIYCL EQLSTKPDAD IDTTHLSVDV SSPDLFGSIH
710 720 730 740 750
EDFSLTSEQR LLIVLSNCCY LERHTFLNIA EHFEKHNFQG IEKITQVSMA
760 770 780 790 800
SLKELDQRLF ENYIELKADP IVGSLEPGIY AGYFDWKDCL PPAGVRNYLK
810 820 830 840 850
EALVNIIAVH AEVFTISKEL VPRVLARVVE AVSEELSRLM QCVSSFSRNG
860 870 880 890 900
ALQARLEICA LRDTVAIYLT SESRSSFKQA LEALPQLASG ADKKSLEELL
910 920
NKFKSSMHLQ LTCFQAASPA VMKT
Length:924
Mass (Da):103,959
Last modified:June 1, 2001 - v1
Checksum:i457BAD92EAA3040B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016532 mRNA Translation: BAB30290.1
AK050068 mRNA Translation: BAC34056.1
BC048154 mRNA Translation: AAH48154.1
BC049102 mRNA Translation: AAH49102.1
CCDSiCCDS26420.1
RefSeqiNP_079864.1, NM_025588.2
XP_006516789.1, XM_006516726.2
UniGeneiMm.293510

Genome annotation databases

EnsembliENSMUST00000021785; ENSMUSP00000021785; ENSMUSG00000021357
ENSMUST00000102946; ENSMUSP00000100010; ENSMUSG00000021357
GeneIDi66482
KEGGimmu:66482
UCSCiuc007pzc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016532 mRNA Translation: BAB30290.1
AK050068 mRNA Translation: BAC34056.1
BC048154 mRNA Translation: AAH48154.1
BC049102 mRNA Translation: AAH49102.1
CCDSiCCDS26420.1
RefSeqiNP_079864.1, NM_025588.2
XP_006516789.1, XM_006516726.2
UniGeneiMm.293510

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HK6NMR-A5-97[»]
ProteinModelPortaliQ9D4H1
SMRiQ9D4H1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211506, 2 interactors
IntActiQ9D4H1, 2 interactors
MINTiQ9D4H1
STRINGi10090.ENSMUSP00000021785

PTM databases

iPTMnetiQ9D4H1
PhosphoSitePlusiQ9D4H1

Proteomic databases

EPDiQ9D4H1
MaxQBiQ9D4H1
PaxDbiQ9D4H1
PeptideAtlasiQ9D4H1
PRIDEiQ9D4H1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021785; ENSMUSP00000021785; ENSMUSG00000021357
ENSMUST00000102946; ENSMUSP00000100010; ENSMUSG00000021357
GeneIDi66482
KEGGimmu:66482
UCSCiuc007pzc.1 mouse

Organism-specific databases

CTDi55770
MGIiMGI:1913732 Exoc2

Phylogenomic databases

eggNOGiKOG2347 Eukaryota
ENOG410XSY3 LUCA
GeneTreeiENSGT00390000010872
HOGENOMiHOG000044231
HOVERGENiHBG028469
InParanoidiQ9D4H1
KOiK17637
OMAiEWKSPNK
OrthoDBiEOG091G02P6
PhylomeDBiQ9D4H1
TreeFamiTF105891

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRSiExoc2 mouse
EvolutionaryTraceiQ9D4H1
PROiPR:Q9D4H1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021357 Expressed in 245 organ(s), highest expression level in bone marrow
CleanExiMM_EXOC2
GenevisibleiQ9D4H1 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR029175 EXOC2/Sec5
IPR039481 EXOC2/Sec5_N_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
PANTHERiPTHR13043 PTHR13043, 1 hit
PfamiView protein in Pfam
PF15469 Sec5, 1 hit
PF01833 TIG, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC2_MOUSE
AccessioniPrimary (citable) accession number: Q9D4H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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