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Protein

RecQ-mediated genome instability protein 1

Gene

Rmi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-MMU-5685938 HDR through Single Strand Annealing (SSA)
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-MMU-5693579 Homologous DNA Pairing and Strand Exchange
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Recommended name:
RecQ-mediated genome instability protein 1
Gene namesi
Name:Rmi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1921636 Rmi1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275471 – 616RecQ-mediated genome instability protein 1Add BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Cross-linki335Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki387Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D4G9
MaxQBiQ9D4G9
PaxDbiQ9D4G9
PeptideAtlasiQ9D4G9
PRIDEiQ9D4G9

PTM databases

iPTMnetiQ9D4G9
PhosphoSitePlusiQ9D4G9

Expressioni

Gene expression databases

BgeeiENSMUSG00000035367 Expressed in 201 organ(s), highest expression level in embryo
GenevisibleiQ9D4G9 MM

Interactioni

Subunit structurei

Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2 and TOP3A. May bind DHJ. Interacts (via N-terminal region) with BLM; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

BioGridi216710, 8 interactors
ComplexPortaliCPX-3303 BTR double Holliday Junction dissolution complex
IntActiQ9D4G9, 6 interactors
STRINGi10090.ENSMUSP00000041035

Structurei

3D structure databases

ProteinModelPortaliQ9D4G9
SMRiQ9D4G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RMI1 family.Curated

Phylogenomic databases

eggNOGiENOG410INNR Eukaryota
ENOG410Z65I LUCA
GeneTreeiENSGT00740000115530
HOGENOMiHOG000154148
HOVERGENiHBG061190
InParanoidiQ9D4G9
KOiK10990
OMAiQGMEYQS
OrthoDBiEOG091G0GU8
PhylomeDBiQ9D4G9
TreeFamiTF316491

Family and domain databases

InterProiView protein in InterPro
IPR033472 DUF1767
IPR039215 RMI1
IPR032199 RMI1_C
IPR013894 RMI1_N
PANTHERiPTHR14790 PTHR14790, 1 hit
PfamiView protein in Pfam
PF16099 RMI1_C, 1 hit
PF08585 RMI1_N, 1 hit
SMARTiView protein in SMART
SM01161 DUF1767, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D4G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVASAVLRV ETWLLATWHV KVPPMWLEAC VNWIQEENNN ATLSQAQINK
60 70 80 90 100
QVLEQWLLTD LRDLEHPLLP DDILELPKGE LNGFYALQIN SLVDVSQPAY
110 120 130 140 150
SQIQKLRGKN TTNDLVSAET QSTPKPWEVR PSRMLMLQLT DGVTHIQGME
160 170 180 190 200
YQSIPALHSG LPPGTKILVR GCILFRLGVL LLKPENVKVL GGEVDGLSEE
210 220 230 240 250
NAQEKVLARL IGELDPTVPV IPNNSIHNVP KVSGGLDAVL GPSDEELLAS
260 270 280 290 300
LDESEESAAN NDVAMERSCF STGTSSNTTP TNPSGFEPGC NISSRPKEKP
310 320 330 340 350
PNQPTHFTDG EFDDFSLEEA LLLEETVQKE QMETKASQPL TLKENTGKCM
360 370 380 390 400
EIFSHKPSSL NHTALIHKQG NSNFDEKTSE QMIHEDKFFD CASTRNHHKR
410 420 430 440 450
FSAHDFTNDS KISEVDDAAQ QTLSSSNVHC LRNKILNRKL DLSEKSSQIS
460 470 480 490 500
KENGHPFQAC SSRSFENNTY LSIGMDLHSP PFIYLSVLMA RKPKEVTTVT
510 520 530 540 550
VKAFIVTLTG NLSSSGGFWG VTAKVSDGTA YLDVDFIDEI LTSMIGYSVP
560 570 580 590 600
EMKQLRKDPL KYKTFLEGLQ KCQRDLIDLC CLMTISYDPS SCKGVVLELQ
610
DVGMEHVENL KKRLNK
Length:616
Mass (Da):68,465
Last modified:June 1, 2001 - v1
Checksum:i2C70E918FD911803
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73I → V in AAH37694 (PubMed:15489334).Curated1
Sequence conflicti74L → S in BAC37651 (PubMed:16141072).Curated1
Sequence conflicti170R → H in AAH37694 (PubMed:15489334).Curated1
Sequence conflicti252D → G in AAH37694 (PubMed:15489334).Curated1
Sequence conflicti411K → E in AAH37694 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016542 mRNA Translation: BAB30292.1
AK032229 mRNA Translation: BAC27772.1
AK079457 mRNA Translation: BAC37651.1
BC037694 mRNA Translation: AAH37694.1
CCDSiCCDS26571.1
RefSeqiNP_001161720.1, NM_001168248.1
NP_083180.3, NM_028904.3
XP_006517483.1, XM_006517420.3
UniGeneiMm.85289

Genome annotation databases

EnsembliENSMUST00000042450; ENSMUSP00000041035; ENSMUSG00000035367
ENSMUST00000224479; ENSMUSP00000153050; ENSMUSG00000035367
ENSMUST00000225815; ENSMUSP00000153621; ENSMUSG00000035367
ENSMUST00000225828; ENSMUSP00000153675; ENSMUSG00000035367
GeneIDi74386
KEGGimmu:74386
UCSCiuc007qua.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016542 mRNA Translation: BAB30292.1
AK032229 mRNA Translation: BAC27772.1
AK079457 mRNA Translation: BAC37651.1
BC037694 mRNA Translation: AAH37694.1
CCDSiCCDS26571.1
RefSeqiNP_001161720.1, NM_001168248.1
NP_083180.3, NM_028904.3
XP_006517483.1, XM_006517420.3
UniGeneiMm.85289

3D structure databases

ProteinModelPortaliQ9D4G9
SMRiQ9D4G9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216710, 8 interactors
ComplexPortaliCPX-3303 BTR double Holliday Junction dissolution complex
IntActiQ9D4G9, 6 interactors
STRINGi10090.ENSMUSP00000041035

PTM databases

iPTMnetiQ9D4G9
PhosphoSitePlusiQ9D4G9

Proteomic databases

EPDiQ9D4G9
MaxQBiQ9D4G9
PaxDbiQ9D4G9
PeptideAtlasiQ9D4G9
PRIDEiQ9D4G9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042450; ENSMUSP00000041035; ENSMUSG00000035367
ENSMUST00000224479; ENSMUSP00000153050; ENSMUSG00000035367
ENSMUST00000225815; ENSMUSP00000153621; ENSMUSG00000035367
ENSMUST00000225828; ENSMUSP00000153675; ENSMUSG00000035367
GeneIDi74386
KEGGimmu:74386
UCSCiuc007qua.2 mouse

Organism-specific databases

CTDi80010
MGIiMGI:1921636 Rmi1

Phylogenomic databases

eggNOGiENOG410INNR Eukaryota
ENOG410Z65I LUCA
GeneTreeiENSGT00740000115530
HOGENOMiHOG000154148
HOVERGENiHBG061190
InParanoidiQ9D4G9
KOiK10990
OMAiQGMEYQS
OrthoDBiEOG091G0GU8
PhylomeDBiQ9D4G9
TreeFamiTF316491

Enzyme and pathway databases

ReactomeiR-MMU-5685938 HDR through Single Strand Annealing (SSA)
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-MMU-5693579 Homologous DNA Pairing and Strand Exchange
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-69473 G2/M DNA damage checkpoint

Miscellaneous databases

PROiPR:Q9D4G9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035367 Expressed in 201 organ(s), highest expression level in embryo
GenevisibleiQ9D4G9 MM

Family and domain databases

InterProiView protein in InterPro
IPR033472 DUF1767
IPR039215 RMI1
IPR032199 RMI1_C
IPR013894 RMI1_N
PANTHERiPTHR14790 PTHR14790, 1 hit
PfamiView protein in Pfam
PF16099 RMI1_C, 1 hit
PF08585 RMI1_N, 1 hit
SMARTiView protein in SMART
SM01161 DUF1767, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRMI1_MOUSE
AccessioniPrimary (citable) accession number: Q9D4G9
Secondary accession number(s): Q8C560, Q8CI20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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