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Protein

Gamma-tubulin complex component 4

Gene

Tubgcp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.By similarity

GO - Molecular functioni

  • gamma-tubulin binding Source: GO_Central
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 4
Short name:
GCP-4
Gene namesi
Name:Tubgcp4
Synonyms:D2Ertd435e, Gcp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1196293 Tubgcp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781251 – 667Gamma-tubulin complex component 4Add BLAST667

Proteomic databases

EPDiQ9D4F8
MaxQBiQ9D4F8
PaxDbiQ9D4F8
PRIDEiQ9D4F8

PTM databases

PhosphoSitePlusiQ9D4F8

Expressioni

Gene expression databases

BgeeiENSMUSG00000027263 Expressed in 283 organ(s), highest expression level in muscle tissue
CleanExiMM_TUBGCP4
ExpressionAtlasiQ9D4F8 baseline and differential
GenevisibleiQ9D4F8 MM

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with NINL. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206244, 8 interactors
IntActiQ9D4F8, 8 interactors
MINTiQ9D4F8
STRINGi10090.ENSMUSP00000044049

Structurei

3D structure databases

ProteinModelPortaliQ9D4F8
SMRiQ9D4F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2065 Eukaryota
ENOG410XPES LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000234444
HOVERGENiHBG023386
InParanoidiQ9D4F8
KOiK16571
OrthoDBiEOG091G01V2
PhylomeDBiQ9D4F8
TreeFamiTF324188

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D4F8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIHELLLALS GYPGSIFTWN KRSGLQVSQD FPFLHPSETS VLNRLCRLGT
60 70 80 90 100
DYIRFTEFIE QYTGHVQQQD HHPPQQGQGG LHGIYLRAFC TGLDSVLQPY
110 120 130 140 150
RQALLDLEQE FLADPHLSIS HVNYSLDQFQ LLFPSVMVVV EQIKSQKIHG
160 170 180 190 200
CQILETVYKH SCGGLPPVRS ALEKILAVCH GVMYKQLSAW MLHGLLLDQH
210 220 230 240 250
EEFFIKQGPS SGTLSAQLEE DEEDLGIGGL TGKQLRELQD LRLIEEENML
260 270 280 290 300
APSLKQFSLR VEILPSYIPV RVAEKILFVG ESVQMFENQN VNLTRKGSIL
310 320 330 340 350
KNQEDTFAAE LHRLKQQPLF SLVDFEQVVD RIRSTVAEHL WKLMVEESDL
360 370 380 390 400
LGQLKIIKDF YLLGRGELFQ AFIDTAQHML KTPPTAVTEH DVNVAFQQSA
410 420 430 440 450
HKVLLDDDNL LPLLHLTIEY HGKDHKADAT QPREVPSRET SPREAPSSGW
460 470 480 490 500
AALGLSYKVQ WPLHILFTPA VLEKYNVVFK YLLSVRRVQA ELQHCWALQM
510 520 530 540 550
QRKHLKSNQT DAVKWRLRNH MAFLVDNLQY YLQVDVLESQ FSQLLHQINS
560 570 580 590 600
TRDFESIRLA HDHFLSNLLA QSFILLKPVF HCLNEILDLC HSFCSLVSQN
610 620 630 640 650
LGPLDERGAA QLSILVKGFS RQSSLLFKIL SSVRNHQINS DLAQLLLRLD
660
YNKYYTQAGG TLGSFGM
Length:667
Mass (Da):76,126
Last modified:August 2, 2002 - v2
Checksum:i32CC26F5D69D2CF6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BYN2Q8BYN2_MOUSE
Gamma-tubulin complex component
Tubgcp4 D2Ertd435e, mCG_11966
666Annotation score:
Q8BKL6Q8BKL6_MOUSE
Gamma-tubulin complex component
Tubgcp4 D2Ertd435e
620Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029106 mRNA Translation: AAH29106.1
AK016563 mRNA No translation available.
CCDSiCCDS16637.1
RefSeqiNP_700436.1, NM_153387.3
UniGeneiMm.383499

Genome annotation databases

EnsembliENSMUST00000039541; ENSMUSP00000044049; ENSMUSG00000027263
GeneIDi51885
KEGGimmu:51885
UCSCiuc008lxv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029106 mRNA Translation: AAH29106.1
AK016563 mRNA No translation available.
CCDSiCCDS16637.1
RefSeqiNP_700436.1, NM_153387.3
UniGeneiMm.383499

3D structure databases

ProteinModelPortaliQ9D4F8
SMRiQ9D4F8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206244, 8 interactors
IntActiQ9D4F8, 8 interactors
MINTiQ9D4F8
STRINGi10090.ENSMUSP00000044049

PTM databases

PhosphoSitePlusiQ9D4F8

Proteomic databases

EPDiQ9D4F8
MaxQBiQ9D4F8
PaxDbiQ9D4F8
PRIDEiQ9D4F8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039541; ENSMUSP00000044049; ENSMUSG00000027263
GeneIDi51885
KEGGimmu:51885
UCSCiuc008lxv.2 mouse

Organism-specific databases

CTDi27229
MGIiMGI:1196293 Tubgcp4

Phylogenomic databases

eggNOGiKOG2065 Eukaryota
ENOG410XPES LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000234444
HOVERGENiHBG023386
InParanoidiQ9D4F8
KOiK16571
OrthoDBiEOG091G01V2
PhylomeDBiQ9D4F8
TreeFamiTF324188

Enzyme and pathway databases

ReactomeiR-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

PROiPR:Q9D4F8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027263 Expressed in 283 organ(s), highest expression level in muscle tissue
CleanExiMM_TUBGCP4
ExpressionAtlasiQ9D4F8 baseline and differential
GenevisibleiQ9D4F8 MM

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCP4_MOUSE
AccessioniPrimary (citable) accession number: Q9D4F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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