UniProtKB - Q9D4C9 (CLVS1_MOUSE)
Protein
Clavesin-1
Gene
Clvs1
Organism
Mus musculus (Mouse)
Status
Functioni
Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).By similarity
Miscellaneous
Binding to PtdIns(3,5)P2 is not required for localization.By similarity
GO - Molecular functioni
- phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
- phosphatidylinositol bisphosphate binding Source: GO_Central
GO - Biological processi
- lysosome organization Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-MMU-432720, Lysosome Vesicle Biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Clavesin-1Alternative name(s): Retinaldehyde-binding protein 1-like 1 |
Gene namesi | Name:Clvs1 Synonyms:Rlbp1l1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921688, Clvs1 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane By similarity; Peripheral membrane protein By similarity
Endosome
- Early endosome membrane By similarity; Peripheral membrane protein By similarity
Other locations
- clathrin-coated vesicle By similarity
Endosome
- early endosome membrane Source: UniProtKB-SubCell
- endosome Source: UniProtKB
Golgi apparatus
- trans-Golgi network Source: UniProtKB
Other locations
- clathrin-coated vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297656 | 1 – 354 | Clavesin-1Add BLAST | 354 |
Proteomic databases
PaxDbi | Q9D4C9 |
PeptideAtlasi | Q9D4C9 |
PRIDEi | Q9D4C9 |
PTM databases
iPTMneti | Q9D4C9 |
PhosphoSitePlusi | Q9D4C9 |
SwissPalmi | Q9D4C9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041216, Expressed in facial nucleus and 223 other tissues |
Genevisiblei | Q9D4C9, MM |
Interactioni
Subunit structurei
Forms a complex with clathrin heavy chain and gamma-adaptin.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035649 |
Miscellaneous databases
RNActi | Q9D4C9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 279 | CRAL-TRIOPROSITE-ProRule annotationAdd BLAST | 162 |
Domaini
The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.By similarity
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000159947 |
HOGENOMi | CLU_046597_1_3_1 |
InParanoidi | Q9D4C9 |
OMAi | IHFIGQP |
OrthoDBi | 1182715at2759 |
PhylomeDBi | Q9D4C9 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR028634, Clavesin-1 IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf |
PANTHERi | PTHR10174:SF72, PTHR10174:SF72, 1 hit |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF03765, CRAL_TRIO_N, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9D4C9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPVSVLPSP QSLSTWEGDL AKMTHLQAGL SPDTIEKARL ELNENPDILH
60 70 80 90 100
QDIQQVRDMI ITRPDIGFLR TDDAFILRFL RARKFHQADA FRLLAQYFQY
110 120 130 140 150
RQLNLDMFKN FKADDPGIKR ALIDGFPGVL ENRDHYGRKI LLLFAANWDQ
160 170 180 190 200
SRNSFTDILR AILLSLEVLI EDPELQINGF ILIIDWSNFS FKQASKLTPS
210 220 230 240 250
ILKLAIEGLQ DSFPARFGGV HFVNQPWYIH ALYTLIKPFL KDKTRKRIFL
260 270 280 290 300
HGNNLNSLHQ LIHPEFLPSE FGGTLPPYDM GTWARTLLGP DYSDENDYTH
310 320 330 340 350
TSYNAMHVKH TCSNLERECS PKPMKRSQSV VEAGTLKHEE KGENENTQPL
LALD
Sequence cautioni
The sequence BAE22811 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 307 | H → Q in BAE22811 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027330 | 1 – 279 | Missing in isoform 3. 1 PublicationAdd BLAST | 279 | |
Alternative sequenceiVSP_027331 | 153 – 354 | Missing in isoform 2. 1 PublicationAdd BLAST | 202 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016622 mRNA Translation: BAB30342.1 AK043072 mRNA Translation: BAC31451.1 AK084350 mRNA Translation: BAC39166.1 AK136083 mRNA Translation: BAE22811.1 Different initiation. AL671970 Genomic DNA No translation available. AL844180 Genomic DNA No translation available. BC062923 mRNA Translation: AAH62923.1 BC100556 mRNA Translation: AAI00557.1 |
CCDSi | CCDS17957.1 [Q9D4C9-1] |
RefSeqi | NP_083216.1, NM_028940.2 [Q9D4C9-1] XP_011248427.1, XM_011250125.2 |
Genome annotation databases
Ensembli | ENSMUST00000038841; ENSMUSP00000035649; ENSMUSG00000041216 [Q9D4C9-1] ENSMUST00000108348; ENSMUSP00000103985; ENSMUSG00000041216 [Q9D4C9-1] |
GeneIDi | 74438 |
KEGGi | mmu:74438 |
UCSCi | uc008ryc.2, mouse [Q9D4C9-2] uc008rye.2, mouse [Q9D4C9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016622 mRNA Translation: BAB30342.1 AK043072 mRNA Translation: BAC31451.1 AK084350 mRNA Translation: BAC39166.1 AK136083 mRNA Translation: BAE22811.1 Different initiation. AL671970 Genomic DNA No translation available. AL844180 Genomic DNA No translation available. BC062923 mRNA Translation: AAH62923.1 BC100556 mRNA Translation: AAI00557.1 |
CCDSi | CCDS17957.1 [Q9D4C9-1] |
RefSeqi | NP_083216.1, NM_028940.2 [Q9D4C9-1] XP_011248427.1, XM_011250125.2 |
3D structure databases
SMRi | Q9D4C9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035649 |
PTM databases
iPTMneti | Q9D4C9 |
PhosphoSitePlusi | Q9D4C9 |
SwissPalmi | Q9D4C9 |
Proteomic databases
PaxDbi | Q9D4C9 |
PeptideAtlasi | Q9D4C9 |
PRIDEi | Q9D4C9 |
Protocols and materials databases
Antibodypediai | 24702, 94 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000038841; ENSMUSP00000035649; ENSMUSG00000041216 [Q9D4C9-1] ENSMUST00000108348; ENSMUSP00000103985; ENSMUSG00000041216 [Q9D4C9-1] |
GeneIDi | 74438 |
KEGGi | mmu:74438 |
UCSCi | uc008ryc.2, mouse [Q9D4C9-2] uc008rye.2, mouse [Q9D4C9-1] |
Organism-specific databases
CTDi | 157807 |
MGIi | MGI:1921688, Clvs1 |
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000159947 |
HOGENOMi | CLU_046597_1_3_1 |
InParanoidi | Q9D4C9 |
OMAi | IHFIGQP |
OrthoDBi | 1182715at2759 |
PhylomeDBi | Q9D4C9 |
Enzyme and pathway databases
Reactomei | R-MMU-432720, Lysosome Vesicle Biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 74438, 0 hits in 17 CRISPR screens |
ChiTaRSi | Clvs1, mouse |
PROi | PR:Q9D4C9 |
RNActi | Q9D4C9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041216, Expressed in facial nucleus and 223 other tissues |
Genevisiblei | Q9D4C9, MM |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR028634, Clavesin-1 IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf |
PANTHERi | PTHR10174:SF72, PTHR10174:SF72, 1 hit |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF03765, CRAL_TRIO_N, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLVS1_MOUSE | |
Accessioni | Q9D4C9Primary (citable) accession number: Q9D4C9 Secondary accession number(s): Q3UWV3 Q8BXX0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot