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UniProtKB - Q9D4C1 (LMTD1_MOUSE)

Entry version 116 (07 Apr 2021)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Lamin tail domain-containing protein 1

Gene

Lmntd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lamin tail domain-containing protein 1
Alternative name(s):
Intermediate filament tail domain-containing protein 1
Lamin-A-related sequence 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lmntd1
Synonyms:Ifltd1, Lmna-rs1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1921321, Lmntd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172491 – 413Lamin tail domain-containing protein 1Add BLAST413

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9D4C1

PRoteomics IDEntifications database

More...PRIDEi		Q9D4C1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		292343

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9D4C1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000054966, Expressed in interventricular septum and 77 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9D4C1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9D4C1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000107337

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9D4C1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9D4C1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini169 – 287LTDPROSITE-ProRule annotationAdd BLAST119

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0977, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00910000144343

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9D4C1

Database of Orthologous Groups

More...OrthoDBi		716378at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9D4C1

TreeFam database of animal gene trees

More...TreeFami		TF338357

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1260, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001322, Lamin_tail_dom
IPR036415, Lamin_tail_dom_sf
IPR042840, LMNTD1

The PANTHER Classification System

More...PANTHERi		PTHR47012, PTHR47012, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00932, LTD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF74853, SSF74853, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51841, LTD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9D4C1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMKEASEPLA SVTSINKQDS KVQDGEIRKE KIGTITPSKQ HSSVHFFPKI 
        60         70         80         90        100
MDSDSTTLIP LSRSFSQEMP IGFYQITSTQ NSSTLSSRGQ LASKSTILSC 
       110        120        130        140        150
SHKDSSLGKQ STSSMVPRRQ PQSSSDVDTY TFGNGEDYFL SLFGESKKLT 
       160        170        180        190        200
AHTPQAENVS EHLSVILEEV GQFTSSSLGE IKIAEVNIKG LFVRLVNSSN 
       210        220        230        240        250
EKEVEIGNHI LQQNVNGHAV SLYQFPDNIT LQANSTVTVW AAASEAKPQP 
       260        270        280        290        300
PTDFVWEEQS KFRSSPDCTT ILCKPNGEAI AWYTPIHWKQ AWEKLETDIE 
       310        320        330        340        350
FERCSVVVPS MRNHMFGWIT ASVSSTNEEK EEPIQKTPSQ VYPVLYREKE 
       360        370        380        390        400
IPPTVLPNKS PWCRNPNTSP HPYSSLIDSH DSDISESSLD TQLKPQPTKP 
       410 
KPDPGTKKKK AKS
Length:413
Mass (Da):45,937
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02EB148B74948CF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q8Y6E9Q8Y6_MOUSE
Lamin tail domain-containing protei...
Lmntd1 Ifltd1
363Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PY33E9PY33_MOUSE
Lamin tail domain-containing protei...
Lmntd1 Ifltd1
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2KFR3B2KFR3_MOUSE
Lamin tail domain-containing protei...
Lmntd1 Ifltd1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti218H → R in AAV31718 (Ref. 1) Curated1
Sequence conflicti258E → G in AAV31718 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY753326 mRNA Translation: AAV31718.1
AK016641 mRNA Translation: BAB30353.1
BC053420 mRNA Translation: AAH53420.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS20695.1

NCBI Reference Sequences

More...RefSeqi		NP_083018.1, NM_028742.2
XP_017177272.1, XM_017321783.1
XP_017177273.1, XM_017321784.1
XP_017177274.1, XM_017321785.1
XP_017177275.1, XM_017321786.1
XP_017177276.1, XM_017321787.1
XP_017177277.1, XM_017321788.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000111708; ENSMUSP00000107337; ENSMUSG00000054966

Database of genes from NCBI RefSeq genomes

More...GeneIDi		74071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:74071

UCSC genome browser

More...UCSCi		uc009ero.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY753326 mRNA Translation: AAV31718.1
AK016641 mRNA Translation: BAB30353.1
BC053420 mRNA Translation: AAH53420.1
CCDSiCCDS20695.1
RefSeqiNP_083018.1, NM_028742.2
XP_017177272.1, XM_017321783.1
XP_017177273.1, XM_017321784.1
XP_017177274.1, XM_017321785.1
XP_017177275.1, XM_017321786.1
XP_017177276.1, XM_017321787.1
XP_017177277.1, XM_017321788.1

3D structure databases

SMRiQ9D4C1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107337

PTM databases

PhosphoSitePlusiQ9D4C1

Proteomic databases

PaxDbiQ9D4C1
PRIDEiQ9D4C1
ProteomicsDBi292343

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42350, 110 antibodies

Genome annotation databases

EnsembliENSMUST00000111708; ENSMUSP00000107337; ENSMUSG00000054966
GeneIDi74071
KEGGimmu:74071
UCSCiuc009ero.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		160492
MGIiMGI:1921321, Lmntd1

Phylogenomic databases

eggNOGiKOG0977, Eukaryota
GeneTreeiENSGT00910000144343
InParanoidiQ9D4C1
OrthoDBi716378at2759
PhylomeDBiQ9D4C1
TreeFamiTF338357

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		74071, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Lmntd1, mouse

Protein Ontology

More...PROi		PR:Q9D4C1
RNActiQ9D4C1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000054966, Expressed in interventricular septum and 77 other tissues
ExpressionAtlasiQ9D4C1, baseline and differential
GenevisibleiQ9D4C1, MM

Family and domain databases

Gene3Di2.60.40.1260, 1 hit
InterProiView protein in InterPro
IPR001322, Lamin_tail_dom
IPR036415, Lamin_tail_dom_sf
IPR042840, LMNTD1
PANTHERiPTHR47012, PTHR47012, 1 hit
PfamiView protein in Pfam
PF00932, LTD, 1 hit
SUPFAMiSSF74853, SSF74853, 1 hit
PROSITEiView protein in PROSITE
PS51841, LTD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMTD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D4C1
Secondary accession number(s): Q5UE52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: April 7, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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