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Protein

Tetratricopeptide repeat protein 25

Gene

Ttc25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 25
Short name:
TPR repeat protein 25
Gene namesi
Name:Ttc25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921657 Ttc25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Heterozygous intercrosses reveal deviation from the Mendelian distribution, with only 6 homozygous out of 53 born mice, suggesting increased death in utero. Most surviving homozygous mice present with small body size, some with hydrocephalus at the age of 2 weeks. They display a variety of left-right body asymmetry defects, including reversal of lung lobation or dextrocardia. At the cell level, the trachea and fallopian tubes of mutant animals show absence of outer dynein arms from the ciliary axonemes, and consequently severe reduction of cilia beating. There is no evidence of short cilia or a reduction in cilia number.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845081 – 624Tetratricopeptide repeat protein 25Add BLAST624

Proteomic databases

MaxQBiQ9D4B2
PaxDbiQ9D4B2
PRIDEiQ9D4B2

PTM databases

iPTMnetiQ9D4B2
PhosphoSitePlusiQ9D4B2

Expressioni

Developmental stagei

At 7.5 dpc, strong expression restricted to the ventral node, the left-right organizer (PubMed:27486780). Up-regulated in tracheal epithelial cells during in vitro differentiation into multiciliated cells (PubMed:25860617).2 Publications

Gene expression databases

BgeeiENSMUSG00000006784 Expressed in 117 organ(s), highest expression level in testis
CleanExiMM_TTC25
ExpressionAtlasiQ9D4B2 baseline and differential
GenevisibleiQ9D4B2 MM

Interactioni

Subunit structurei

Interacts with CCDC114 (By similarity). Interacts with components of the IFT complex A, including IFT140, TTC21B/IFT139 and WDR19/IFT144, and the IFT complex B, including IFT46, IFT52 and IFT57 (PubMed:25860617).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090355

Structurei

3D structure databases

ProteinModelPortaliQ9D4B2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 44TPR 1Add BLAST34
Repeati46 – 78TPR 2Add BLAST33
Repeati79 – 112TPR 3Add BLAST34
Repeati273 – 309TPR 4Add BLAST37
Repeati318 – 351TPR 5Add BLAST34
Repeati358 – 391TPR 6Add BLAST34
Repeati395 – 428TPR 7Add BLAST34
Repeati435 – 468TPR 8Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000007911
HOGENOMiHOG000068108
HOVERGENiHBG106810
InParanoidiQ9D4B2
OrthoDBiEOG091G0FJ6
PhylomeDBiQ9D4B2
TreeFamiTF323661

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D4B2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDGDILRST FPSYMAEGER LYLCGEFTKA IQSFTNALHL QSGDKNCLVA
60 70 80 90 100
RSKCYLKMGD LEKSLNDAEA SLRNDPTFCK GILQKAETLY TMGDFEFALV
110 120 130 140 150
FYHRGYKLRP DREFKVGIQK AQEAINNSVG SPSSIKLENK GDLSFLSKQA
160 170 180 190 200
ESKKAQQKHL PIKQLSYSTK HEIKRKGSLK SEKTVRQLLG ELYVDKEYLE
210 220 230 240 250
KLLLDEDLIK GTIKSGLTVE DLIMTGINYL DTRSNFWRQQ KPIYARERDR
260 270 280 290 300
KLMQEKWLRD RKRSPSQTAH YILKSLEDID MLLTSGSADG SLQKAEKVLK
310 320 330 340 350
KVLEWNQEEV PNKDELVGNL YSCIGNAQIE LGQMVAALQS HRKDLEIAKE
360 370 380 390 400
HDLPDAKSRA LDNIGRVFAR VGKFQQAIDT WEEKIPLAKT TLEKTWLFHE
410 420 430 440 450
IGRCYLELDQ AWQAQSYGEK SQQYAEEEGD LEWQLNASVL VAQAQVKLRD
460 470 480 490 500
FESAVNNFEK ALERAKLVHN NEAQQAIISA LDDANKGIIE ELKKTNYREI
510 520 530 540 550
LREKAERQDI MSQMDLQGAS EKEPLRGREE QERVVKQWER DQESEREATD
560 570 580 590 600
DEQDRKSSGG LSKKLLGDGH SSNLGIRRES REIYRRLSDY SSHLPSEDGS
610 620
QKQEKKQAEA AKGEVQKLEK TKEE
Length:624
Mass (Da):71,530
Last modified:November 3, 2009 - v3
Checksum:i0E8D9B701545FA19
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8A5X0B8A5X0_MOUSE
Tetratricopeptide repeat protein 25
Ttc25
506Annotation score:

Sequence cautioni

The sequence AAH50805 differs from that shown. Reason: Frameshift at position 379.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123E → K in BAB30363 (PubMed:16141072).Curated1
Sequence conflicti277E → D in BAB30363 (PubMed:16141072).Curated1
Sequence conflicti330E → K in BAB30363 (PubMed:16141072).Curated1
Sequence conflicti357K → E in BAB30363 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016657 mRNA Translation: BAB30363.1
BX842667 Genomic DNA No translation available.
BC050805 mRNA Translation: AAH50805.2 Frameshift.
CCDSiCCDS36331.1
RefSeqiNP_083194.2, NM_028918.2
UniGeneiMm.31590

Genome annotation databases

EnsembliENSMUST00000092684; ENSMUSP00000090355; ENSMUSG00000006784
GeneIDi74407
KEGGimmu:74407
UCSCiuc007lln.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016657 mRNA Translation: BAB30363.1
BX842667 Genomic DNA No translation available.
BC050805 mRNA Translation: AAH50805.2 Frameshift.
CCDSiCCDS36331.1
RefSeqiNP_083194.2, NM_028918.2
UniGeneiMm.31590

3D structure databases

ProteinModelPortaliQ9D4B2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090355

PTM databases

iPTMnetiQ9D4B2
PhosphoSitePlusiQ9D4B2

Proteomic databases

MaxQBiQ9D4B2
PaxDbiQ9D4B2
PRIDEiQ9D4B2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092684; ENSMUSP00000090355; ENSMUSG00000006784
GeneIDi74407
KEGGimmu:74407
UCSCiuc007lln.1 mouse

Organism-specific databases

CTDi83538
MGIiMGI:1921657 Ttc25

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000007911
HOGENOMiHOG000068108
HOVERGENiHBG106810
InParanoidiQ9D4B2
OrthoDBiEOG091G0FJ6
PhylomeDBiQ9D4B2
TreeFamiTF323661

Miscellaneous databases

PROiPR:Q9D4B2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006784 Expressed in 117 organ(s), highest expression level in testis
CleanExiMM_TTC25
ExpressionAtlasiQ9D4B2 baseline and differential
GenevisibleiQ9D4B2 MM

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTTC25_MOUSE
AccessioniPrimary (citable) accession number: Q9D4B2
Secondary accession number(s): A2BI62, Q80X58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 3, 2009
Last modified: November 7, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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