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Protein

UV-stimulated scaffold protein A

Gene

Uvssa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
UV-stimulated scaffold protein A
Gene namesi
Name:Uvssa
Synonyms:Kiaa1530
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1918351 Uvssa

Subcellular locationi

Keywords - Cellular componenti

Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172831 – 717UV-stimulated scaffold protein AAdd BLAST717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284PhosphoserineBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei403PhosphoserineCombined sources1

Post-translational modificationi

Monoubiquitinated: ubiquitination does not increase in response to UV.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9D479
PaxDbiQ9D479
PeptideAtlasiQ9D479
PRIDEiQ9D479

PTM databases

iPTMnetiQ9D479
PhosphoSitePlusiQ9D479

Expressioni

Gene expression databases

BgeeiENSMUSG00000037355 Expressed in 234 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_4933407H18RIK
ExpressionAtlasiQ9D479 baseline and differential
GenevisibleiQ9D479 MM

Interactioni

Subunit structurei

Interacts with the elongating form of RNA polymerase II (RNA pol IIo). Interacts with ERCC6, ERCC8 and USP7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085170

Structurei

3D structure databases

ProteinModelPortaliQ9D479
SMRiQ9D479
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 145VHS-likeAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili169 – 199Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi654 – 662Poly-Lys9

Sequence similaritiesi

Belongs to the UVSSA family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2374 Eukaryota
ENOG410XP15 LUCA
GeneTreeiENSGT00390000000377
HOGENOMiHOG000060117
HOVERGENiHBG076421
InParanoidiQ9D479
OMAiYEPHIPD
OrthoDBiEOG091G054F
PhylomeDBiQ9D479
TreeFamiTF321660

Family and domain databases

Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR018610 UVSSA
PANTHERiPTHR28670 PTHR28670, 1 hit
PfamiView protein in Pfam
PF09740 DUF2043, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D479-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQKLSQLIE ELTTSGESQL NAQKMKELKK ICKSSEEQLS HAYRLLITQL
60 70 80 90 100
TQGHAEIRLS AFQIVDELFT RSHQFRMLLV SDFQEFLELT LGTDSDRPLP
110 120 130 140 150
PPREAAQRLR QAAMQAVEGW NEKFGQAYKK LALGYHFLKH TKKVDFRDIN
160 170 180 190 200
VRTVAERKRE EEKQKHLDKI HRESADRAKR EMEEMYDEIE CCLTEVENCF
210 220 230 240 250
KLLVPLDFVP CPEDKFFGEA SSMTEGYAPC PLSPDLATPR ESGLSGPQDE
260 270 280 290 300
EQPCCSKDLV ASAYHVGSVV GLKALPQTAM KDSSRDEDEP SDPDDFLRSH
310 320 330 340 350
GLGSHKYTLD VEVPSDGLKV QENEDNLAVL HAARDSLKLI QNKFLPTVCS
360 370 380 390 400
WVQRFTRAGT YSAHLKQAID LKMELELALK KYEELNIEPG RGQRSRTEAL
410 420 430 440 450
EDSEDEDQDF VEVPEKEGYE PRIPDHLRAE YGLEPKAPLK TLEKGTAVCK
460 470 480 490 500
LQERTRMRRE EEASDPTSAA AQMLRLQDCL SSPSPSSTRV LPGPEEAQKQ
510 520 530 540 550
AERARAPIVP FGVDLCYWGQ EQLTAGKILK SDSQHRFWKP SEVEEEVDSA
560 570 580 590 600
HVSEMLHSRH ITFSGTFEPV QHKCRALRPN GRLCERQDRL KCPFHGKIIP
610 620 630 640 650
RDDKGQPLNP EDRAREQRQQ LQRQQAHPDW QDPEFLKDVE AATGVDLGSS
660 670 680 690 700
RSSKKGKGKK KKHPNLTDLR ERTNTARARL EKKVFAKAAV QRVVAAMNQM
710
DQKKHEKFAN QFNYALK
Length:717
Mass (Da):81,759
Last modified:June 13, 2012 - v2
Checksum:iACC97A8DFAB47BB5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZL9E9PZL9_MOUSE
UV-stimulated scaffold protein A
Uvssa
532Annotation score:

Sequence cautioni

The sequence BAB30399 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC98194 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82D → G in AAI44921 (PubMed:15489334).Curated1
Sequence conflicti397 – 442Missing in BAC98194 (PubMed:14621295).CuratedAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016722 mRNA Translation: BAB30399.1 Different initiation.
AK156117 mRNA Translation: BAE33591.1
AC145072 Genomic DNA No translation available.
CH466524 Genomic DNA Translation: EDL37418.1
BC061483 mRNA Translation: AAH61483.1
BC137803 mRNA Translation: AAI37804.1
BC144920 mRNA Translation: AAI44921.1
AK129384 Transcribed RNA Translation: BAC98194.1 Different initiation.
CCDSiCCDS39064.1
RefSeqiNP_001074570.1, NM_001081101.2
XP_006504171.1, XM_006504108.3
UniGeneiMm.132178

Genome annotation databases

EnsembliENSMUST00000087864; ENSMUSP00000085170; ENSMUSG00000037355
ENSMUST00000202816; ENSMUSP00000144400; ENSMUSG00000037355
GeneIDi71101
KEGGimmu:71101
UCSCiuc008xar.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016722 mRNA Translation: BAB30399.1 Different initiation.
AK156117 mRNA Translation: BAE33591.1
AC145072 Genomic DNA No translation available.
CH466524 Genomic DNA Translation: EDL37418.1
BC061483 mRNA Translation: AAH61483.1
BC137803 mRNA Translation: AAI37804.1
BC144920 mRNA Translation: AAI44921.1
AK129384 Transcribed RNA Translation: BAC98194.1 Different initiation.
CCDSiCCDS39064.1
RefSeqiNP_001074570.1, NM_001081101.2
XP_006504171.1, XM_006504108.3
UniGeneiMm.132178

3D structure databases

ProteinModelPortaliQ9D479
SMRiQ9D479
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085170

PTM databases

iPTMnetiQ9D479
PhosphoSitePlusiQ9D479

Proteomic databases

MaxQBiQ9D479
PaxDbiQ9D479
PeptideAtlasiQ9D479
PRIDEiQ9D479

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087864; ENSMUSP00000085170; ENSMUSG00000037355
ENSMUST00000202816; ENSMUSP00000144400; ENSMUSG00000037355
GeneIDi71101
KEGGimmu:71101
UCSCiuc008xar.1 mouse

Organism-specific databases

CTDi57654
MGIiMGI:1918351 Uvssa
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2374 Eukaryota
ENOG410XP15 LUCA
GeneTreeiENSGT00390000000377
HOGENOMiHOG000060117
HOVERGENiHBG076421
InParanoidiQ9D479
OMAiYEPHIPD
OrthoDBiEOG091G054F
PhylomeDBiQ9D479
TreeFamiTF321660

Enzyme and pathway databases

ReactomeiR-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Miscellaneous databases

PROiPR:Q9D479
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037355 Expressed in 234 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_4933407H18RIK
ExpressionAtlasiQ9D479 baseline and differential
GenevisibleiQ9D479 MM

Family and domain databases

Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR018610 UVSSA
PANTHERiPTHR28670 PTHR28670, 1 hit
PfamiView protein in Pfam
PF09740 DUF2043, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUVSSA_MOUSE
AccessioniPrimary (citable) accession number: Q9D479
Secondary accession number(s): B2RQ84
, B7ZN03, Q3U1A8, Q6P7V8, Q6ZPN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 13, 2012
Last modified: November 7, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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