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Protein

Cilia- and flagella-associated protein 53

Gene

Cfap53

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 53Imported
Alternative name(s):
Coiled-coil domain-containing protein 11Imported
Gene namesi
Name:Cfap53Imported
Synonyms:Ccdc11Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1921703 Cfap53

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894081 – 514Cilia- and flagella-associated protein 53Add BLAST514

Proteomic databases

PaxDbiQ9D439
PRIDEiQ9D439

PTM databases

iPTMnetiQ9D439
PhosphoSitePlusiQ9D439

Expressioni

Gene expression databases

BgeeiENSMUSG00000035394 Expressed in 66 organ(s), highest expression level in testis
CleanExiMM_CCDC11
ExpressionAtlasiQ9D439 baseline and differential
GenevisibleiQ9D439 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110545

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili91 – 176Sequence analysisAdd BLAST86
Coiled coili205 – 478Sequence analysisAdd BLAST274

Sequence similaritiesi

Belongs to the CFAP53 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFT8 Eukaryota
ENOG410Y53F LUCA
GeneTreeiENSGT00730000111221
HOGENOMiHOG000111401
HOVERGENiHBG081036
InParanoidiQ9D439
OMAiNIHPMRR
OrthoDBiEOG091G0BHQ
PhylomeDBiQ9D439
TreeFamiTF329393

Family and domain databases

InterProiView protein in InterPro
IPR033365 CFAP53
PANTHERiPTHR31183:SF1 PTHR31183:SF1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYSQQFGTVP REFKGPTPKA VIIRAKPPKA QRAEQHLKRI QRSYHKYHTT
60 70 80 90 100
LASIKSNEEN RLKCDWIQRN NHKTFDSLVQ ARVQDAMQGF VINTEERRNK
110 120 130 140 150
LRELLASEEN EYFSEMQLKG ETIEEKKDKM RERTKLLREK KEKERQEFVA
160 170 180 190 200
EKLDQQFRER CEELRTKLAS IHEKKVVEER NAQIEFNKEL KRQKLVEEHL
210 220 230 240 250
FARLWEEDRL AKERREAQEE KRQRELVQNT RLGLDAQVTS IQAQRQGARR
260 270 280 290 300
MKEEEARILE QNKAQIKRED EQEKLQKQKR RQETRSSLKK AVQDKIESMQ
310 320 330 340 350
REYREDLDLN MKLVGRALQD LQDEADKKKQ KREEMGREQK IYNDYLMQRR
360 370 380 390 400
EEEKAQEKEL NRLLEDIKAK KLAEKDRELA LQRAARKQLM NEVMNTRKLQ
410 420 430 440 450
VQERLQRKLR EQEELALHEQ RISESLKVLH QEDMEDFARR CALAEEYRNQ
460 470 480 490 500
LQMQIAHQQQ AREAEKEEER QEFEAGLAAN KACLDKIQRI LSENQALSQN
510
VHPMRRGYPD KPPL
Length:514
Mass (Da):61,911
Last modified:November 28, 2006 - v3
Checksum:iC327DD862CFA7AAB
GO
Isoform 2 (identifier: Q9D439-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Note: No experimental confirmation available.
Show »
Length:428
Mass (Da):51,812
Checksum:i719AB93EABD9FE31
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJA5H3BJA5_MOUSE
Cilia- and flagella-associated prot...
Cfap53 Ccdc11
38Annotation score:

Sequence cautioni

The sequence AAH99500 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0572331 – 86Missing in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016821 mRNA Translation: BAB30450.1
BC099500 mRNA Translation: AAH99500.1 Different initiation.
CCDSiCCDS37857.2 [Q9D439-1]
RefSeqiNP_083224.2, NM_028948.2 [Q9D439-1]
XP_011245314.1, XM_011247012.1 [Q9D439-2]
UniGeneiMm.182293

Genome annotation databases

EnsembliENSMUST00000114895; ENSMUSP00000110545; ENSMUSG00000035394 [Q9D439-1]
GeneIDi74453
KEGGimmu:74453
UCSCiuc008fpl.2 mouse [Q9D439-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016821 mRNA Translation: BAB30450.1
BC099500 mRNA Translation: AAH99500.1 Different initiation.
CCDSiCCDS37857.2 [Q9D439-1]
RefSeqiNP_083224.2, NM_028948.2 [Q9D439-1]
XP_011245314.1, XM_011247012.1 [Q9D439-2]
UniGeneiMm.182293

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110545

PTM databases

iPTMnetiQ9D439
PhosphoSitePlusiQ9D439

Proteomic databases

PaxDbiQ9D439
PRIDEiQ9D439

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114895; ENSMUSP00000110545; ENSMUSG00000035394 [Q9D439-1]
GeneIDi74453
KEGGimmu:74453
UCSCiuc008fpl.2 mouse [Q9D439-1]

Organism-specific databases

CTDi220136
MGIiMGI:1921703 Cfap53

Phylogenomic databases

eggNOGiENOG410IFT8 Eukaryota
ENOG410Y53F LUCA
GeneTreeiENSGT00730000111221
HOGENOMiHOG000111401
HOVERGENiHBG081036
InParanoidiQ9D439
OMAiNIHPMRR
OrthoDBiEOG091G0BHQ
PhylomeDBiQ9D439
TreeFamiTF329393

Miscellaneous databases

PROiPR:Q9D439
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035394 Expressed in 66 organ(s), highest expression level in testis
CleanExiMM_CCDC11
ExpressionAtlasiQ9D439 baseline and differential
GenevisibleiQ9D439 MM

Family and domain databases

InterProiView protein in InterPro
IPR033365 CFAP53
PANTHERiPTHR31183:SF1 PTHR31183:SF1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCFA53_MOUSE
AccessioniPrimary (citable) accession number: Q9D439
Secondary accession number(s): Q4KL15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 28, 2006
Last modified: September 12, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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