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Protein

Calcium-binding tyrosine phosphorylation-regulated protein

Gene

Cabyr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • enzyme binding Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

  • calcium-mediated signaling Source: BHF-UCL
  • protein complex oligomerization Source: BHF-UCL
  • sperm capacitation Source: BHF-UCL

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding tyrosine phosphorylation-regulated protein
Alternative name(s):
Calcium-binding protein 86
Testis-specific calcium-binding protein CBP86
Gene namesi
Name:Cabyr
Synonyms:Cbp86
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1918382 Cabyr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892701 – 453Calcium-binding tyrosine phosphorylation-regulated proteinAdd BLAST453

Post-translational modificationi

Phosphorylated on tyrosine residues during in vitro capacitation. Dephosphorylation affects its ability to bind calcium (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D424
PRIDEiQ9D424

PTM databases

iPTMnetiQ9D424
PhosphoSitePlusiQ9D424

Expressioni

Tissue specificityi

Expressed in spermatozoa.1 Publication

Gene expression databases

BgeeiENSMUSG00000024430
ExpressionAtlasiQ9D424 baseline and differential
GenevisibleiQ9D424 MM

Interactioni

Subunit structurei

Interacts with FSCB.1 Publication

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi214495, 5 interactors
STRINGi10090.ENSMUSP00000079277

Structurei

3D structure databases

ProteinModelPortaliQ9D424
SMRiQ9D424
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 49RIIaAdd BLAST38

Phylogenomic databases

eggNOGiENOG410IFPT Eukaryota
ENOG410ZQAQ LUCA
GeneTreeiENSGT00390000000444
HOGENOMiHOG000059568
HOVERGENiHBG080982
InParanoidiQ9D424
OMAiEQIVIPF
OrthoDBiEOG091G18VB
PhylomeDBiQ9D424
TreeFamiTF332959

Family and domain databases

InterProiView protein in InterPro
IPR038848 CABYR
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
PANTHERiPTHR15494 PTHR15494, 1 hit
PfamiView protein in Pfam
PF02197 RIIa, 1 hit
SMARTiView protein in SMART
SM00394 RIIa, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D424-1) [UniParc]FASTAAdd to basket
Also known as: CBP86-1, CBP86-6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISSKPRLVV PYGLKTLLEG VSRAILKTNP TNITQFAAVY FKELIVFREG
60 70 80 90 100
NSSLDIKDLI KQFHQMKVEK WAEGVTVEKK ECIKEPIKPP PVPCKPTHME
110 120 130 140 150
KSTDTEEDNV AGPLFSNKTT QFPSVHAEVQ SEETSEGARG PSDKPTTPKT
160 170 180 190 200
DYTPPSSPPP APVSAEYAYV PADPAQFAAQ MLGNVPSTYS EVLMVDVATS
210 220 230 240 250
TPAVPQDVLS AEFAEEVVLS APLVCSGETV EVQVVSKTSA QVVVGPVSEA
260 270 280 290 300
EPPKASSAPL QGEQEPPAHE APDTQVTSAS RISSIYNDVP VNEGVVYVEE
310 320 330 340 350
IPGYIVIPFT DHDQVACVKE IEQSPPGSPK AVEPKTKISI ESLKTVQVEE
360 370 380 390 400
NSQHKSSVHV EAEATVLLSN TALDGQPEVP AEPLDAEGFF KVASENSLHL
410 420 430 440 450
ETEIVIINPD DPGQEESGGN AAPHSSGDPF PPAPGGLTEP EMQPDGEAAP

EQV
Length:453
Mass (Da):48,333
Last modified:June 1, 2001 - v1
Checksum:i7BCA9EB34D89F472
GO
Isoform 2 (identifier: Q9D424-2) [UniParc]FASTAAdd to basket
Also known as: CBP86-2

The sequence of this isoform differs from the canonical sequence as follows:
     183-381: GNVPSTYSEV...ALDGQPEVPA → ALATSEAGQP...TTAHVRRAEP
     382-453: Missing.

Show »
Length:381
Mass (Da):41,307
Checksum:i123A4CE9826DD44F
GO
Isoform 3 (identifier: Q9D424-3) [UniParc]FASTAAdd to basket
Also known as: CBP86-4

The sequence of this isoform differs from the canonical sequence as follows:
     183-220: GNVPSTYSEV...AEFAEEVVLS → EDVAKKSSGS...TTAHVRRAEP
     221-453: Missing.

Show »
Length:220
Mass (Da):23,985
Checksum:iE1665615F2F0A7B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17L → P in AAK49988 (PubMed:12801634).Curated1
Sequence conflicti41F → L in AAK49988 (PubMed:12801634).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016252183 – 381GNVPS…PEVPA → ALATSEAGQPPPYSNMWTLY CLTDMNQQSRPSPPPAPGPF PQATLYLPNPKEPQFLQNPP KVTSPTYVMMDDSKKTNAPP FILVGSNVQEAQDWNPLPGH AVVSQAEALKRYAAVQVPIA VPADQTFQRPAPNPQNASPP TSGQDGPRPKSPVFLSVAFP VEDVAKKSSGSGDKRTPFGS YGIAGEITVTTAHVRRAEP in isoform 2. 1 PublicationAdd BLAST199
Alternative sequenceiVSP_016253183 – 220GNVPS…EVVLS → EDVAKKSSGSGDKRTPFGSY GIAGEITVTTAHVRRAEP in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_016254221 – 453Missing in isoform 3. 1 PublicationAdd BLAST233
Alternative sequenceiVSP_016255382 – 453Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359382 mRNA Translation: AAK49987.1
AF359383 mRNA Translation: AAK49988.1
AF359384 mRNA Translation: AAK49989.1
AF359385 mRNA Translation: AAK49990.1
AK016856 mRNA Translation: BAB30467.1
CCDSiCCDS37739.1 [Q9D424-1]
CCDS50223.1 [Q9D424-2]
CCDS50224.1 [Q9D424-3]
RefSeqiNP_001035883.1, NM_001042418.1 [Q9D424-1]
NP_001035884.1, NM_001042419.1 [Q9D424-3]
NP_001035885.1, NM_001042420.1 [Q9D424-1]
NP_081963.1, NM_027687.2 [Q9D424-1]
NP_859420.2, NM_181731.3 [Q9D424-2]
XP_017173468.1, XM_017317979.1 [Q9D424-1]
UniGeneiMm.179740

Genome annotation databases

EnsembliENSMUST00000080415; ENSMUSP00000079277; ENSMUSG00000024430 [Q9D424-1]
ENSMUST00000115857; ENSMUSP00000111523; ENSMUSG00000024430 [Q9D424-1]
ENSMUST00000119108; ENSMUSP00000113760; ENSMUSG00000024430 [Q9D424-3]
ENSMUST00000121018; ENSMUSP00000113131; ENSMUSG00000024430 [Q9D424-2]
ENSMUST00000150758; ENSMUSP00000118330; ENSMUSG00000024430 [Q9D424-1]
ENSMUST00000186263; ENSMUSP00000140870; ENSMUSG00000024430 [Q9D424-1]
ENSMUST00000191078; ENSMUSP00000140894; ENSMUSG00000024430 [Q9D424-1]
GeneIDi71132
KEGGimmu:71132
UCSCiuc008ecl.1 mouse [Q9D424-3]
uc008ecm.1 mouse [Q9D424-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCABYR_MOUSE
AccessioniPrimary (citable) accession number: Q9D424
Secondary accession number(s): Q91Y41, Q91Y42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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