Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box only protein 24

Gene

Fbxo24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 24
Gene namesi
Name:Fbxo24
Synonyms:Fbx24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1918426 Fbxo24

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199101 – 589F-box only protein 24Add BLAST589

Proteomic databases

PaxDbiQ9D417
PRIDEiQ9D417

PTM databases

PhosphoSitePlusiQ9D417

Expressioni

Gene expression databases

BgeeiENSMUSG00000089984 Expressed in 25 organ(s), highest expression level in testis
CleanExiMM_FBXO24
ExpressionAtlasiQ9D417 baseline and differential
GenevisibleiQ9D417 MM

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi214532, 2 interactors
STRINGi10090.ENSMUSP00000031732

Structurei

3D structure databases

ProteinModelPortaliQ9D417
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 69F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati386 – 435RCC1Add BLAST50

Phylogenomic databases

eggNOGiENOG410IQCV Eukaryota
ENOG41100N3 LUCA
GeneTreeiENSGT00390000017455
HOGENOMiHOG000253007
HOVERGENiHBG051571
InParanoidiQ9D417
KOiK10304
OMAiEPTQVHY
OrthoDBiEOG091G043B
PhylomeDBiQ9D417
TreeFamiTF328722

Family and domain databases

Gene3Di2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00415 RCC1, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF50985 SSF50985, 2 hits
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS50012 RCC1_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D417-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKRSCPSCG LEAGSEKKER GNPISVQLFP PELVEHIVSF LPVKDLVALG
60 70 80 90 100
QTCHYFHEVC DAEGVWRRIC RRLSPRIRDQ SSGARPWKRA AILNYTKGLY
110 120 130 140 150
FQAFGGRRRC LSKSVAPMLA HGYRRFLPTK DHVFILDYVG TLFFLKNALV
160 170 180 190 200
SSTLGQIQWK RACRYVVLCR GAKDFASDPR CDTVYRKYLY VLATREQPAV
210 220 230 240 250
VGTTGSRACD CVEVYLQSSG QRVFKMTFHH SMSFKQIVLV GQETQRALLL
260 270 280 290 300
LTEEGKIYSL VVNETQLDQP RSYTVQLALR KVSRCLPHLR VTCMASNQSS
310 320 330 340 350
TLYITGGTLI PRKQVPKAAE LRAPDPPDQG GVYFEVHTPG VYRDLFGTLQ
360 370 380 390 400
AFDPLDHQMP LALSLPAKVL FCALGYNHLG LVDEFGRIFM QGNNRYGQLG
410 420 430 440 450
TGDKMDRGEP TQVHYLQRPI ALWCGLNHSL VLSQTSDFSK ELLGCGCGAG
460 470 480 490 500
GRLPGWPKGS ASFVKLHIKV PLCACSLCST RECLYMLSSH DIEQCPVYRD
510 520 530 540 550
LPASRVGGSP EPSQGAGAPQ DPGGTAQACE EYLSQIHSCP TLQDRMEKMK
560 570 580
EIVGWMPLMA AQKDFFWEAL DMLQRAAGGA GPDTSTPES
Length:589
Mass (Da):65,429
Last modified:June 1, 2001 - v1
Checksum:iF4FB50703BD4D270
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZY9D3YZY9_MOUSE
F-box only protein 24
Fbxo24
450Annotation score:
D6RFP4D6RFP4_MOUSE
F-box only protein 24
Fbxo24
92Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016870 mRNA Translation: BAB30476.1
CCDSiCCDS51674.1
RefSeqiNP_081984.1, NM_027708.1
XP_006504682.1, XM_006504619.3
UniGeneiMm.474695

Genome annotation databases

EnsembliENSMUST00000031732; ENSMUSP00000031732; ENSMUSG00000089984
GeneIDi71176
KEGGimmu:71176
UCSCiuc009adc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016870 mRNA Translation: BAB30476.1
CCDSiCCDS51674.1
RefSeqiNP_081984.1, NM_027708.1
XP_006504682.1, XM_006504619.3
UniGeneiMm.474695

3D structure databases

ProteinModelPortaliQ9D417
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214532, 2 interactors
STRINGi10090.ENSMUSP00000031732

PTM databases

PhosphoSitePlusiQ9D417

Proteomic databases

PaxDbiQ9D417
PRIDEiQ9D417

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031732; ENSMUSP00000031732; ENSMUSG00000089984
GeneIDi71176
KEGGimmu:71176
UCSCiuc009adc.1 mouse

Organism-specific databases

CTDi26261
MGIiMGI:1918426 Fbxo24

Phylogenomic databases

eggNOGiENOG410IQCV Eukaryota
ENOG41100N3 LUCA
GeneTreeiENSGT00390000017455
HOGENOMiHOG000253007
HOVERGENiHBG051571
InParanoidiQ9D417
KOiK10304
OMAiEPTQVHY
OrthoDBiEOG091G043B
PhylomeDBiQ9D417
TreeFamiTF328722

Miscellaneous databases

ChiTaRSiFbxo24 mouse
PROiPR:Q9D417
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089984 Expressed in 25 organ(s), highest expression level in testis
CleanExiMM_FBXO24
ExpressionAtlasiQ9D417 baseline and differential
GenevisibleiQ9D417 MM

Family and domain databases

Gene3Di2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00415 RCC1, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF50985 SSF50985, 2 hits
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS50012 RCC1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX24_MOUSE
AccessioniPrimary (citable) accession number: Q9D417
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again