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UniProtKB - Q9D415 (DLGP1_MOUSE)

Entry version 161 (23 Feb 2022)
Sequence version 3 (19 Jul 2005)
Previous versions | rss
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Protein

Disks large-associated protein 1

Gene

Dlgap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the postsynaptic scaffold in neuronal cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-6794361, Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disks large-associated protein 1
Short name:
DAP-1
Alternative name(s):
Guanylate kinase-associated protein
PSD-95/SAP90-binding protein 1
SAP90/PSD-95-associated protein 1
Short name:
SAPAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dlgap1
Synonyms:Gkap, Kiaa4162
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1346065, Dlgap1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000003279

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001742891 – 992Disks large-associated protein 1Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei169PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei389PhosphoserineBy similarity1
Modified residuei418PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1
Modified residuei428PhosphoserineBy similarity1
Modified residuei437PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1
Modified residuei579PhosphothreonineCombined sources1
Modified residuei581PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei606PhosphothreonineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei611PhosphoserineBy similarity1
Modified residuei947PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9D415

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9D415

PeptideAtlas

More...PeptideAtlasi		Q9D415

PRoteomics IDEntifications database

More...PRIDEi		Q9D415

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		279780 [Q9D415-1]
279781 [Q9D415-2]
279782 [Q9D415-3]
279783 [Q9D415-4]
279784 [Q9D415-5]
279785 [Q9D415-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9D415

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9D415

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in the neocortex, part of the hippocampus, the granule cell layer of the cerebellum, the glomerular layer of the olfactory bulb, the inner plexiform layer of the retina, the ventral and dorsal horn of the spinal chord, the neuromuscular junction and the submandibular ganglion.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000003279, Expressed in CA1 field of hippocampus and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9D415, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9D415, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1.

Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3.

Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3.

Found in a complex with DLG4 and BEGAIN.

Interacts with DYL2 and LRFN1.

Interacts with MPP2 (via the SH3-Guanylate kinase-like sub-module) (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		230347, 165 interactors

Protein interaction database and analysis system

More...IntActi		Q9D415, 157 interactors

Molecular INTeraction database

More...MINTi		Q9D415

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000122896

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9D415, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9D415

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni150 – 209DisorderedSequence analysisAdd BLAST60
Regioni355 – 376DisorderedSequence analysisAdd BLAST22
Regioni665 – 676Interaction with DYL2By similarityAdd BLAST12
Regioni687 – 698Interaction with DYL2By similarityAdd BLAST12
Regioni914 – 980DisorderedSequence analysisAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi990 – 992PDZ-bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi174 – 193Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi194 – 209Polar residuesSequence analysisAdd BLAST16
Compositional biasi914 – 931Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi948 – 962Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3971, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010880_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9D415

Identification of Orthologs from Complete Genome Data

More...OMAi		ACAGDDY

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9D415

TreeFam database of animal gene trees

More...TreeFami		TF321382

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030524, DLGAP1
IPR005026, SAPAP

The PANTHER Classification System

More...PANTHERi		PTHR12353, PTHR12353, 1 hit
PTHR12353:SF7, PTHR12353:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03359, GKAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D415-1) [UniParc]FASTAAdd to basket
Also known as: SAPAP1

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGLSGSRSH HHGITCEAAC DSLSHHSDHK PYLLSPVDHH PADHPYYTQR 
        60         70         80         90        100
NSFQAECVGP FSDPLASSTF PRRHYTSQQE LKDESALVPR TLATKANRLP 
       110        120        130        140        150
TNLLDQFERQ LPLSRDGYHT LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT 
       160        170        180        190        200
KSHSLEGPSK GSVNGGKASP DESQTLRYGK RSKSKERRSE SKARSNASNA 
       210        220        230        240        250
SPTSPSWWSS DDNLDGDMCL YHTPSGVMTM GRCPDRSASQ YFMEAYNTIS 
       260        270        280        290        300
EQAVKASRSN NDIKCSTCAN LPVTLDAPLL KKSAWSSTLT VSRAREVYQK 
       310        320        330        340        350
ASVNMDQAMV KSEACQQERS CQYLQVPQDE WSGYTPRGKD DEIPCRRMRS 
       360        370        380        390        400
GSYIKAMGDE DSGDSDTSPK PSPKVAARRE SYLKATQPSL TELTTLKISN 
       410        420        430        440        450
EHSPKLQIRS HSYLRAVSEV SINRSLDSLD PAGLLTSPKF RSRNESYMRA 
       460        470        480        490        500
MSTISQVSEM EVNGQFESVC ESVFSELESQ AVEALDLPLP GCFRMRSHSY 
       510        520        530        540        550
VRAIEKGCSQ DDECVSLRSS SPPRTTTTVR TIQSSTGVIK LSSAVEVSSC 
       560        570        580        590        600
ITTYKKTPPP VPPRTTTKPF ISITAQSSTE SAQDAYMDGQ GQRGDMISQS 
       610        620        630        640        650
GLSNSTESLD SMKALTAAIE AANAQIHGPA SQHMGSNAAA VTTTTTIATV 
       660        670        680        690        700
TTEDRKKDFK KNRCLSIGIQ VDDAEEPEKM AESKTSNKFQ SVGVQVEEEK 
       710        720        730        740        750
CFRRFTRSNS VTTAVQADLD FHDNLENSLE SIEDNSCPGP MARQFSRDAS 
       760        770        780        790        800
TSTVSIQGSG NHYHACAADD DFDTDFDPSI LPPPDPWIDS ITEDPLEAVQ 
       810        820        830        840        850
RSVCHRDGHW FLKLLQAERD RMEGWCKLME REERENNLPE DILGKIRTAV 
       860        870        880        890        900
GSAQLLMAQK FYQFRELCEE NLNPNAHPRP TSQDLAGFWD MLQLSIENIS 
       910        920        930        940        950
MKFDELHQLK ANNWKQMDPL DKKERRAPPP VPKKPAKGPA PLIRERSLES 
       960        970        980        990 
SQRQEARKRL MAAKRAASVR QNSATESAES IEIYIPEAQT RL
Length:992
Mass (Da):110,374
Last modified:July 19, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9962C8B56A33EE13
GO
Isoform 2 (identifier: Q9D415-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-546: Missing.

Show »
Length:982
Mass (Da):109,390
Checksum:i9518AAB72BB13EE9
GO
Isoform 3 (identifier: Q9D415-3) [UniParc]FASTAAdd to basket
Also known as: GKAP1a

The sequence of this isoform differs from the canonical sequence as follows:
     547-574: Missing.

Show »
Length:964
Mass (Da):107,331
Checksum:iB45BBAFF2C4E8740
GO
Isoform 4 (identifier: Q9D415-4) [UniParc]FASTAAdd to basket
Also known as: GKAP1b

The sequence of this isoform differs from the canonical sequence as follows:
     537-546: Missing.
     924-944: ERRAPPPVPKKPAKGPAPLIR → VEQCRFCMVHLKPCTNAGQSK
     945-992: Missing.

Show »
Length:934
Mass (Da):104,064
Checksum:i224A365837BCE785
GO
Isoform 5 (identifier: Q9D415-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     538-538: V → E
     539-992: Missing.

Show »
Length:538
Mass (Da):59,879
Checksum:iA562146ADAE2C929
GO
Isoform 6 (identifier: Q9D415-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-992: Missing.

Show »
Length:397
Mass (Da):44,247
Checksum:i63EB6CC30E996F60
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAR5E9QAR5_MOUSE
Disks large-associated protein 1
Dlgap1
682Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z6F4D3Z6F4_MOUSE
Disks large-associated protein 1
Dlgap1
666Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z508D3Z508_MOUSE
Disks large-associated protein 1
Dlgap1
692Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3UVU8Q3UVU8_MOUSE
Disks large-associated protein 1
Dlgap1
636Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z709D3Z709_MOUSE
Disks large-associated protein 1
Dlgap1
944Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WD59A0A3B2WD59_MOUSE
Disks large-associated protein 1
Dlgap1
660Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2W7Z1A0A3B2W7Z1_MOUSE
Disks large-associated protein 1
Dlgap1
726Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD90519 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti383L → P in BAD90519 (Ref. 3) Curated1
Sequence conflicti397K → R in AAP70755 (PubMed:15024750).Curated1
Sequence conflicti431P → H in BAC27391 (PubMed:16141072).Curated1
Sequence conflicti752S → F in BAC28619 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015408398 – 992Missing in isoform 6. 1 PublicationAdd BLAST595
Alternative sequenceiVSP_015409537 – 546Missing in isoform 2 and isoform 4. 3 Publications10
Alternative sequenceiVSP_015410538V → E in isoform 5. 1 Publication1
Alternative sequenceiVSP_015411539 – 992Missing in isoform 5. 1 PublicationAdd BLAST454
Alternative sequenceiVSP_015412547 – 574Missing in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_015413924 – 944ERRAP…APLIR → VEQCRFCMVHLKPCTNAGQS K in isoform 4. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_015414945 – 992Missing in isoform 4. 2 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY243846 mRNA Translation: AAP70755.2
AK031410 mRNA Translation: BAC27391.1
AK033901 mRNA Translation: BAC28508.1
AK034182 mRNA Translation: BAC28619.1
AK220515 mRNA Translation: BAD90519.1 Different initiation.
BC062120 mRNA Translation: AAH62120.1
BC094369 mRNA Translation: AAH94369.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS28953.1 [Q9D415-1]
CCDS84331.1 [Q9D415-3]
CCDS84332.1 [Q9D415-2]

NCBI Reference Sequences

More...RefSeqi		NP_001334340.1, NM_001347411.1 [Q9D415-3]
NP_081988.3, NM_027712.3 [Q9D415-4]
NP_808307.2, NM_177639.6 [Q9D415-1]
XP_006524236.1, XM_006524173.2 [Q9D415-1]
XP_011244709.1, XM_011246407.2 [Q9D415-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000060072; ENSMUSP00000052858; ENSMUSG00000003279 [Q9D415-2]
ENSMUST00000133983; ENSMUSP00000116716; ENSMUSG00000003279 [Q9D415-2]
ENSMUST00000135938; ENSMUSP00000118497; ENSMUSG00000003279 [Q9D415-3]
ENSMUST00000155016; ENSMUSP00000122896; ENSMUSG00000003279 [Q9D415-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		224997

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:224997

UCSC genome browser

More...UCSCi		uc008dky.1, mouse [Q9D415-6]
uc008dla.1, mouse [Q9D415-5]
uc008dle.2, mouse [Q9D415-1]
uc008dlf.2, mouse [Q9D415-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243846 mRNA Translation: AAP70755.2
AK031410 mRNA Translation: BAC27391.1
AK033901 mRNA Translation: BAC28508.1
AK034182 mRNA Translation: BAC28619.1
AK220515 mRNA Translation: BAD90519.1 Different initiation.
BC062120 mRNA Translation: AAH62120.1
BC094369 mRNA Translation: AAH94369.1
CCDSiCCDS28953.1 [Q9D415-1]
CCDS84331.1 [Q9D415-3]
CCDS84332.1 [Q9D415-2]
RefSeqiNP_001334340.1, NM_001347411.1 [Q9D415-3]
NP_081988.3, NM_027712.3 [Q9D415-4]
NP_808307.2, NM_177639.6 [Q9D415-1]
XP_006524236.1, XM_006524173.2 [Q9D415-1]
XP_011244709.1, XM_011246407.2 [Q9D415-1]

3D structure databases

SMRiQ9D415
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230347, 165 interactors
IntActiQ9D415, 157 interactors
MINTiQ9D415
STRINGi10090.ENSMUSP00000122896

PTM databases

iPTMnetiQ9D415
PhosphoSitePlusiQ9D415

Proteomic databases

MaxQBiQ9D415
PaxDbiQ9D415
PeptideAtlasiQ9D415
PRIDEiQ9D415
ProteomicsDBi279780 [Q9D415-1]
279781 [Q9D415-2]
279782 [Q9D415-3]
279783 [Q9D415-4]
279784 [Q9D415-5]
279785 [Q9D415-6]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9D415, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		21914, 253 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		224997

Genome annotation databases

EnsembliENSMUST00000060072; ENSMUSP00000052858; ENSMUSG00000003279 [Q9D415-2]
ENSMUST00000133983; ENSMUSP00000116716; ENSMUSG00000003279 [Q9D415-2]
ENSMUST00000135938; ENSMUSP00000118497; ENSMUSG00000003279 [Q9D415-3]
ENSMUST00000155016; ENSMUSP00000122896; ENSMUSG00000003279 [Q9D415-1]
GeneIDi224997
KEGGimmu:224997
UCSCiuc008dky.1, mouse [Q9D415-6]
uc008dla.1, mouse [Q9D415-5]
uc008dle.2, mouse [Q9D415-1]
uc008dlf.2, mouse [Q9D415-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9229
MGIiMGI:1346065, Dlgap1
VEuPathDBiHostDB:ENSMUSG00000003279

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG3971, Eukaryota
GeneTreeiENSGT00940000156220
HOGENOMiCLU_010880_0_0_1
InParanoidiQ9D415
OMAiACAGDDY
PhylomeDBiQ9D415
TreeFamiTF321382

Enzyme and pathway databases

ReactomeiR-MMU-6794361, Neurexins and neuroligins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		224997, 1 hit in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Dlgap1, mouse

Protein Ontology

More...PROi		PR:Q9D415
RNActiQ9D415, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000003279, Expressed in CA1 field of hippocampus and 203 other tissues
ExpressionAtlasiQ9D415, baseline and differential
GenevisibleiQ9D415, MM

Family and domain databases

InterProiView protein in InterPro
IPR030524, DLGAP1
IPR005026, SAPAP
PANTHERiPTHR12353, PTHR12353, 1 hit
PTHR12353:SF7, PTHR12353:SF7, 1 hit
PfamiView protein in Pfam
PF03359, GKAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLGP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D415
Secondary accession number(s): Q52KF6
, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 19, 2005
Last modified: February 23, 2022
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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