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Protein

Disks large-associated protein 1

Gene

Dlgap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the postsynaptic scaffold in neuronal cells.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 1
Short name:
DAP-1
Alternative name(s):
Guanylate kinase-associated protein
PSD-95/SAP90-binding protein 1
SAP90/PSD-95-associated protein 1
Short name:
SAPAP1
Gene namesi
Name:Dlgap1
Synonyms:Gkap, Kiaa4162
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1346065 Dlgap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742891 – 992Disks large-associated protein 1Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei169PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei389PhosphoserineBy similarity1
Modified residuei418PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1
Modified residuei428PhosphoserineBy similarity1
Modified residuei437PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1
Modified residuei579PhosphothreonineCombined sources1
Modified residuei581PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei606PhosphothreonineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei611PhosphoserineBy similarity1
Modified residuei947PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D415
PeptideAtlasiQ9D415
PRIDEiQ9D415

PTM databases

iPTMnetiQ9D415
PhosphoSitePlusiQ9D415

Expressioni

Tissue specificityi

Highest levels in the neocortex, part of the hippocampus, the granule cell layer of the cerebellum, the glomerular layer of the olfactory bulb, the inner plexiform layer of the retina, the ventral and dorsal horn of the spinal chord, the neuromuscular junction and the submandibular ganglion.1 Publication

Gene expression databases

BgeeiENSMUSG00000003279 Expressed in 174 organ(s), highest expression level in CA1 field of hippocampus
ExpressionAtlasiQ9D415 baseline and differential
GenevisibleiQ9D415 MM

Interactioni

Subunit structurei

Interacts with the guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1. Interacts with MPP2 (via the SH3-Guanylate kinase-like sub-module) (By similarity).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230347, 159 interactors
IntActiQ9D415, 156 interactors
MINTiQ9D415
STRINGi10090.ENSMUSP00000122896

Structurei

3D structure databases

ProteinModelPortaliQ9D415
SMRiQ9D415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni665 – 676Interaction with DYL2By similarityAdd BLAST12
Regioni687 – 698Interaction with DYL2By similarityAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi990 – 992PDZ-bindingBy similarity3

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00550000074473
HOVERGENiHBG018957
InParanoidiQ9D415
KOiK15008
OrthoDBiEOG091G0J9O
TreeFamiTF321382

Family and domain databases

InterProiView protein in InterPro
IPR030524 DLGAP1
IPR005026 SAPAP
PANTHERiPTHR12353 PTHR12353, 1 hit
PTHR12353:SF7 PTHR12353:SF7, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D415-1) [UniParc]FASTAAdd to basket
Also known as: SAPAP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGLSGSRSH HHGITCEAAC DSLSHHSDHK PYLLSPVDHH PADHPYYTQR
60 70 80 90 100
NSFQAECVGP FSDPLASSTF PRRHYTSQQE LKDESALVPR TLATKANRLP
110 120 130 140 150
TNLLDQFERQ LPLSRDGYHT LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT
160 170 180 190 200
KSHSLEGPSK GSVNGGKASP DESQTLRYGK RSKSKERRSE SKARSNASNA
210 220 230 240 250
SPTSPSWWSS DDNLDGDMCL YHTPSGVMTM GRCPDRSASQ YFMEAYNTIS
260 270 280 290 300
EQAVKASRSN NDIKCSTCAN LPVTLDAPLL KKSAWSSTLT VSRAREVYQK
310 320 330 340 350
ASVNMDQAMV KSEACQQERS CQYLQVPQDE WSGYTPRGKD DEIPCRRMRS
360 370 380 390 400
GSYIKAMGDE DSGDSDTSPK PSPKVAARRE SYLKATQPSL TELTTLKISN
410 420 430 440 450
EHSPKLQIRS HSYLRAVSEV SINRSLDSLD PAGLLTSPKF RSRNESYMRA
460 470 480 490 500
MSTISQVSEM EVNGQFESVC ESVFSELESQ AVEALDLPLP GCFRMRSHSY
510 520 530 540 550
VRAIEKGCSQ DDECVSLRSS SPPRTTTTVR TIQSSTGVIK LSSAVEVSSC
560 570 580 590 600
ITTYKKTPPP VPPRTTTKPF ISITAQSSTE SAQDAYMDGQ GQRGDMISQS
610 620 630 640 650
GLSNSTESLD SMKALTAAIE AANAQIHGPA SQHMGSNAAA VTTTTTIATV
660 670 680 690 700
TTEDRKKDFK KNRCLSIGIQ VDDAEEPEKM AESKTSNKFQ SVGVQVEEEK
710 720 730 740 750
CFRRFTRSNS VTTAVQADLD FHDNLENSLE SIEDNSCPGP MARQFSRDAS
760 770 780 790 800
TSTVSIQGSG NHYHACAADD DFDTDFDPSI LPPPDPWIDS ITEDPLEAVQ
810 820 830 840 850
RSVCHRDGHW FLKLLQAERD RMEGWCKLME REERENNLPE DILGKIRTAV
860 870 880 890 900
GSAQLLMAQK FYQFRELCEE NLNPNAHPRP TSQDLAGFWD MLQLSIENIS
910 920 930 940 950
MKFDELHQLK ANNWKQMDPL DKKERRAPPP VPKKPAKGPA PLIRERSLES
960 970 980 990
SQRQEARKRL MAAKRAASVR QNSATESAES IEIYIPEAQT RL
Length:992
Mass (Da):110,374
Last modified:July 19, 2005 - v3
Checksum:i9962C8B56A33EE13
GO
Isoform 2 (identifier: Q9D415-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-546: Missing.

Note: No experimental confirmation available.
Show »
Length:982
Mass (Da):109,390
Checksum:i9518AAB72BB13EE9
GO
Isoform 3 (identifier: Q9D415-3) [UniParc]FASTAAdd to basket
Also known as: GKAP1a

The sequence of this isoform differs from the canonical sequence as follows:
     547-574: Missing.

Show »
Length:964
Mass (Da):107,331
Checksum:iB45BBAFF2C4E8740
GO
Isoform 4 (identifier: Q9D415-4) [UniParc]FASTAAdd to basket
Also known as: GKAP1b

The sequence of this isoform differs from the canonical sequence as follows:
     537-546: Missing.
     924-944: ERRAPPPVPKKPAKGPAPLIR → VEQCRFCMVHLKPCTNAGQSK
     945-992: Missing.

Show »
Length:934
Mass (Da):104,064
Checksum:i224A365837BCE785
GO
Isoform 5 (identifier: Q9D415-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     538-538: V → E
     539-992: Missing.

Note: No experimental confirmation available.
Show »
Length:538
Mass (Da):59,879
Checksum:iA562146ADAE2C929
GO
Isoform 6 (identifier: Q9D415-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     398-992: Missing.

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):44,247
Checksum:i63EB6CC30E996F60
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAR5E9QAR5_MOUSE
Disks large-associated protein 1
Dlgap1
682Annotation score:
D3Z6F4D3Z6F4_MOUSE
Disks large-associated protein 1
Dlgap1
666Annotation score:
D3Z508D3Z508_MOUSE
Disks large-associated protein 1
Dlgap1
692Annotation score:
D3Z709D3Z709_MOUSE
Disks large-associated protein 1
Dlgap1
944Annotation score:
Q3UVU8Q3UVU8_MOUSE
Disks large-associated protein 1
Dlgap1
636Annotation score:

Sequence cautioni

The sequence BAD90519 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti383L → P in BAD90519 (Ref. 3) Curated1
Sequence conflicti397K → R in AAP70755 (PubMed:15024750).Curated1
Sequence conflicti431P → H in BAC27391 (PubMed:16141072).Curated1
Sequence conflicti752S → F in BAC28619 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015408398 – 992Missing in isoform 6. 1 PublicationAdd BLAST595
Alternative sequenceiVSP_015409537 – 546Missing in isoform 2 and isoform 4. 3 Publications10
Alternative sequenceiVSP_015410538V → E in isoform 5. 1 Publication1
Alternative sequenceiVSP_015411539 – 992Missing in isoform 5. 1 PublicationAdd BLAST454
Alternative sequenceiVSP_015412547 – 574Missing in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_015413924 – 944ERRAP…APLIR → VEQCRFCMVHLKPCTNAGQS K in isoform 4. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_015414945 – 992Missing in isoform 4. 2 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243846 mRNA Translation: AAP70755.2
AK031410 mRNA Translation: BAC27391.1
AK033901 mRNA Translation: BAC28508.1
AK034182 mRNA Translation: BAC28619.1
AK220515 mRNA Translation: BAD90519.1 Different initiation.
BC062120 mRNA Translation: AAH62120.1
BC094369 mRNA Translation: AAH94369.1
CCDSiCCDS28953.1 [Q9D415-1]
CCDS84331.1 [Q9D415-3]
CCDS84332.1 [Q9D415-2]
RefSeqiNP_001334340.1, NM_001347411.1 [Q9D415-3]
NP_081988.3, NM_027712.3 [Q9D415-4]
NP_808307.2, NM_177639.6 [Q9D415-1]
XP_006524236.1, XM_006524173.2 [Q9D415-1]
XP_011244709.1, XM_011246407.2 [Q9D415-1]
UniGeneiMm.311840
Mm.367369

Genome annotation databases

EnsembliENSMUST00000060072; ENSMUSP00000052858; ENSMUSG00000003279 [Q9D415-2]
ENSMUST00000133983; ENSMUSP00000116716; ENSMUSG00000003279 [Q9D415-2]
ENSMUST00000135938; ENSMUSP00000118497; ENSMUSG00000003279 [Q9D415-3]
ENSMUST00000155016; ENSMUSP00000122896; ENSMUSG00000003279 [Q9D415-1]
GeneIDi224997
KEGGimmu:224997
UCSCiuc008dky.1 mouse [Q9D415-6]
uc008dla.1 mouse [Q9D415-5]
uc008dle.2 mouse [Q9D415-1]
uc008dlf.2 mouse [Q9D415-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243846 mRNA Translation: AAP70755.2
AK031410 mRNA Translation: BAC27391.1
AK033901 mRNA Translation: BAC28508.1
AK034182 mRNA Translation: BAC28619.1
AK220515 mRNA Translation: BAD90519.1 Different initiation.
BC062120 mRNA Translation: AAH62120.1
BC094369 mRNA Translation: AAH94369.1
CCDSiCCDS28953.1 [Q9D415-1]
CCDS84331.1 [Q9D415-3]
CCDS84332.1 [Q9D415-2]
RefSeqiNP_001334340.1, NM_001347411.1 [Q9D415-3]
NP_081988.3, NM_027712.3 [Q9D415-4]
NP_808307.2, NM_177639.6 [Q9D415-1]
XP_006524236.1, XM_006524173.2 [Q9D415-1]
XP_011244709.1, XM_011246407.2 [Q9D415-1]
UniGeneiMm.311840
Mm.367369

3D structure databases

ProteinModelPortaliQ9D415
SMRiQ9D415
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230347, 159 interactors
IntActiQ9D415, 156 interactors
MINTiQ9D415
STRINGi10090.ENSMUSP00000122896

PTM databases

iPTMnetiQ9D415
PhosphoSitePlusiQ9D415

Proteomic databases

PaxDbiQ9D415
PeptideAtlasiQ9D415
PRIDEiQ9D415

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060072; ENSMUSP00000052858; ENSMUSG00000003279 [Q9D415-2]
ENSMUST00000133983; ENSMUSP00000116716; ENSMUSG00000003279 [Q9D415-2]
ENSMUST00000135938; ENSMUSP00000118497; ENSMUSG00000003279 [Q9D415-3]
ENSMUST00000155016; ENSMUSP00000122896; ENSMUSG00000003279 [Q9D415-1]
GeneIDi224997
KEGGimmu:224997
UCSCiuc008dky.1 mouse [Q9D415-6]
uc008dla.1 mouse [Q9D415-5]
uc008dle.2 mouse [Q9D415-1]
uc008dlf.2 mouse [Q9D415-4]

Organism-specific databases

CTDi9229
MGIiMGI:1346065 Dlgap1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00550000074473
HOVERGENiHBG018957
InParanoidiQ9D415
KOiK15008
OrthoDBiEOG091G0J9O
TreeFamiTF321382

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiDlgap1 mouse
PROiPR:Q9D415
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003279 Expressed in 174 organ(s), highest expression level in CA1 field of hippocampus
ExpressionAtlasiQ9D415 baseline and differential
GenevisibleiQ9D415 MM

Family and domain databases

InterProiView protein in InterPro
IPR030524 DLGAP1
IPR005026 SAPAP
PANTHERiPTHR12353 PTHR12353, 1 hit
PTHR12353:SF7 PTHR12353:SF7, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLGP1_MOUSE
AccessioniPrimary (citable) accession number: Q9D415
Secondary accession number(s): Q52KF6
, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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