UniProtKB - Q9D404 (OXSM_MOUSE)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
Gene
Oxsm
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.By similarity
Catalytic activityi
- EC:2.3.1.41By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Inhibited by cerulenin.By similarity
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: HGNC-UCL
GO - Biological processi
- acyl-CoA metabolic process Source: HGNC-UCL
- fatty acid biosynthetic process Source: GO_Central
- medium-chain fatty acid biosynthetic process Source: HGNC-UCL
- short-chain fatty acid biosynthetic process Source: HGNC-UCL
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialCurated (EC:2.3.1.41By similarity)Alternative name(s): Beta-ketoacyl-ACP synthase |
Gene namesi | Name:OxsmImported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918397, Oxsm |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 27 | MitochondrionSequence analysisAdd BLAST | 27 | |
ChainiPRO_0000232661 | 28 – 459 | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialAdd BLAST | 432 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 109 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 109 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 113 | N6-succinyllysineCombined sources | 1 | |
Modified residuei | 174 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 174 | N6-succinyllysine; alternateCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9D404 |
jPOSTi | Q9D404 |
MaxQBi | Q9D404 |
PaxDbi | Q9D404 |
PRIDEi | Q9D404 |
PTM databases
iPTMneti | Q9D404 |
PhosphoSitePlusi | Q9D404 |
SwissPalmi | Q9D404 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021786, Expressed in liver and 250 other tissues |
Genevisiblei | Q9D404, MM |
Interactioni
Protein-protein interaction databases
IntActi | Q9D404, 2 interactors |
MINTi | Q9D404 |
STRINGi | 10090.ENSMUSP00000022311 |
Miscellaneous databases
RNActi | Q9D404, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1394, Eukaryota |
GeneTreei | ENSGT00940000157768 |
HOGENOMi | CLU_000022_69_2_1 |
InParanoidi | Q9D404 |
OMAi | QIGHCLG |
OrthoDBi | 1014523at2759 |
PhylomeDBi | Q9D404 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9D404-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSKCLQHFL KATISHPYPA SYSWLISKHR FYGTVPAAML RRRVVITGIG
60 70 80 90 100
LVTPLGVGTQ LVWDRLLRGE SGIVSVVGDE YKNIPCSVAA YVPRGPHEGQ
110 120 130 140 150
FNEENFVSKS DAKSMSSSTI MAVGAAELAL KDSGWHPKRE ADQVATGVAI
160 170 180 190 200
GMGMVPLEVI SETALLFQTK GYNKVSPFFV PKILINMAAG QVSIRYKLKG
210 220 230 240 250
PNHSVSTACT TGAHAVGDSF RFIAHGDADV MVAGGTDSCI SPLSLAGFSR
260 270 280 290 300
ARALSSNPDP KLACRPFHPE RDGFVMGEGA AVLVLEEHEH AVQRGARIYA
310 320 330 340 350
EILGYGLSGD AGHITAPDPE GEGALRCMAA AVKDAGVSPE QISYVNAHAT
360 370 380 390 400
STPLGDAAEN RAIKRLFRDH ACALAISSTK GATGHLLGAA GAVEATFTAL
410 420 430 440 450
ACYHQKLPPT LNLDCTEPEF DLNYVPLESQ EWKAEGRCIG LTNSFGFGGT
NATLCIAGM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016905 mRNA Translation: BAB30490.1 AK083617 mRNA Translation: BAC38969.1 AK084829 mRNA Translation: BAC39286.1 |
CCDSi | CCDS26831.1 |
RefSeqi | NP_081971.1, NM_027695.3 XP_006518163.1, XM_006518100.3 XP_006518164.1, XM_006518101.2 XP_006518165.1, XM_006518102.2 XP_006518166.1, XM_006518103.3 |
Genome annotation databases
Ensembli | ENSMUST00000022311; ENSMUSP00000022311; ENSMUSG00000021786 ENSMUST00000112624; ENSMUSP00000108243; ENSMUSG00000021786 ENSMUST00000112625; ENSMUSP00000108244; ENSMUSG00000021786 |
GeneIDi | 71147 |
KEGGi | mmu:71147 |
UCSCi | uc007sgw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016905 mRNA Translation: BAB30490.1 AK083617 mRNA Translation: BAC38969.1 AK084829 mRNA Translation: BAC39286.1 |
CCDSi | CCDS26831.1 |
RefSeqi | NP_081971.1, NM_027695.3 XP_006518163.1, XM_006518100.3 XP_006518164.1, XM_006518101.2 XP_006518165.1, XM_006518102.2 XP_006518166.1, XM_006518103.3 |
3D structure databases
SMRi | Q9D404 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9D404, 2 interactors |
MINTi | Q9D404 |
STRINGi | 10090.ENSMUSP00000022311 |
PTM databases
iPTMneti | Q9D404 |
PhosphoSitePlusi | Q9D404 |
SwissPalmi | Q9D404 |
Proteomic databases
EPDi | Q9D404 |
jPOSTi | Q9D404 |
MaxQBi | Q9D404 |
PaxDbi | Q9D404 |
PRIDEi | Q9D404 |
Protocols and materials databases
Antibodypediai | 11437, 197 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022311; ENSMUSP00000022311; ENSMUSG00000021786 ENSMUST00000112624; ENSMUSP00000108243; ENSMUSG00000021786 ENSMUST00000112625; ENSMUSP00000108244; ENSMUSG00000021786 |
GeneIDi | 71147 |
KEGGi | mmu:71147 |
UCSCi | uc007sgw.1, mouse |
Organism-specific databases
CTDi | 54995 |
MGIi | MGI:1918397, Oxsm |
Phylogenomic databases
eggNOGi | KOG1394, Eukaryota |
GeneTreei | ENSGT00940000157768 |
HOGENOMi | CLU_000022_69_2_1 |
InParanoidi | Q9D404 |
OMAi | QIGHCLG |
OrthoDBi | 1014523at2759 |
PhylomeDBi | Q9D404 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Miscellaneous databases
BioGRID-ORCSi | 71147, 8 hits in 16 CRISPR screens |
ChiTaRSi | Oxsm, mouse |
PROi | PR:Q9D404 |
RNActi | Q9D404, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021786, Expressed in liver and 250 other tissues |
Genevisiblei | Q9D404, MM |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OXSM_MOUSE | |
Accessioni | Q9D404Primary (citable) accession number: Q9D404 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families