UniProtKB - Q9D3X9 (MFA3L_MOUSE)
Protein
Microfibrillar-associated protein 3-like
Gene
Mfap3l
Organism
Mus musculus (Mouse)
Status
Functioni
May participate in the nuclear signaling of EGFR and MAPK1/ERK2.By similarity
Caution
A protein kinase activity has been reported however PROSITE, Pfam do not detect a protein kinase domain. Its enzyme activity is therefore unsure.By similarity
Names & Taxonomyi
Protein namesi | Recommended name: Microfibrillar-associated protein 3-like |
Gene namesi | Name:Mfap3l Synonyms:Kiaa0626 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918556, Mfap3l |
Subcellular locationi
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- Cytoplasm By similarity
Note: Mainly localized in the nucleus.By similarity
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell junction Source: MGI
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 148 | ExtracellularSequence analysisAdd BLAST | 120 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 409 | CytoplasmicSequence analysisAdd BLAST | 240 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000014870 | 29 – 409 | Microfibrillar-associated protein 3-likeAdd BLAST | 381 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 33 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 37 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 68 ↔ 125 | PROSITE-ProRule annotation | ||
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 287 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 298 | PhosphoserineCombined sources | 1 | |
Modified residuei | 303 | PhosphoserineCombined sources | 1 | |
Modified residuei | 306 | PhosphoserineCombined sources | 1 | |
Modified residuei | 307 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q9D3X9 |
PeptideAtlasi | Q9D3X9 |
PRIDEi | Q9D3X9 |
PTM databases
GlyGeni | Q9D3X9, 5 sites |
iPTMneti | Q9D3X9 |
PhosphoSitePlusi | Q9D3X9 |
SwissPalmi | Q9D3X9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031647, Expressed in lacrimal gland and 249 other tissues |
Genevisiblei | Q9D3X9, MM |
Interactioni
Protein-protein interaction databases
IntActi | Q9D3X9, 1 interactor |
STRINGi | 10090.ENSMUSP00000125139 |
Miscellaneous databases
RNActi | Q9D3X9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 141 | Ig-like C2-typePROSITE-ProRule annotationAdd BLAST | 95 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW9J, Eukaryota |
GeneTreei | ENSGT00390000011576 |
HOGENOMi | CLU_056017_2_0_1 |
InParanoidi | Q9D3X9 |
OMAi | GQNFVRQ |
OrthoDBi | 1154642at2759 |
PhylomeDBi | Q9D3X9 |
TreeFami | TF333205 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR039696, MFAP3-like |
PANTHERi | PTHR14340, PTHR14340, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9D3X9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLQKSHLTV CLPPSVPFLI LVSTLATAKS VTNSTLNGTD VVLGSVPVII
60 70 80 90 100
ARTDHIIVKE GSSALINCSA YGFPDLEFKW YNSVGKLLKE MDDEKEKGGG
110 120 130 140 150
KWQMLDGGLL NITKVSFSDR GKYTCVASNI YGTINNTVTL RVIFTSGDMG
160 170 180 190 200
VYYMVVCLVA FTIVMILNIT RLCMMSSHLK KTEKAINEFF RTEGAEKLQK
210 220 230 240 250
AFEIAKRIPI ITSAKTLELA KVTQFKTMEF ARYIEELARS VPLPPLIMNC
260 270 280 290 300
RTIMEEIMEV VGLEEQGQNF VRHTPEGQEA PDRDEVYTIP NSLKRSESPT
310 320 330 340 350
ADSDASSLHE QPQQIAIKVS VHPQSKRDHV DDQEGGHFEV KDEEETEPSE
360 370 380 390 400
EHSPETAEPS TDITTTELTS EETSPVEAPE RGLPPAHLET TEPAVTCDRN
TCIIYESHV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 283 | R → G in BAC40939 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014096 | 1 – 103 | Missing in isoform 2. 1 PublicationAdd BLAST | 103 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016959 mRNA Translation: BAB30523.1 AK089654 mRNA Translation: BAC40939.1 BC095950 mRNA Translation: AAH95950.1 AK122332 mRNA Translation: BAC65614.1 |
CCDSi | CCDS22321.1 [Q9D3X9-1] CCDS80877.1 [Q9D3X9-2] |
RefSeqi | NP_001171352.1, NM_001177881.1 [Q9D3X9-1] NP_001171353.1, NM_001177882.1 [Q9D3X9-1] NP_001280698.1, NM_001293769.1 [Q9D3X9-2] NP_082032.1, NM_027756.5 [Q9D3X9-1] |
Genome annotation databases
Ensembli | ENSMUST00000034066; ENSMUSP00000034066; ENSMUSG00000031647 [Q9D3X9-1] ENSMUST00000160719; ENSMUSP00000125139; ENSMUSG00000031647 [Q9D3X9-1] ENSMUST00000161421; ENSMUSP00000124136; ENSMUSG00000031647 [Q9D3X9-2] ENSMUST00000161702; ENSMUSP00000124330; ENSMUSG00000031647 [Q9D3X9-1] |
GeneIDi | 71306 |
KEGGi | mmu:71306 |
UCSCi | uc009ltf.3, mouse [Q9D3X9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK016959 mRNA Translation: BAB30523.1 AK089654 mRNA Translation: BAC40939.1 BC095950 mRNA Translation: AAH95950.1 AK122332 mRNA Translation: BAC65614.1 |
CCDSi | CCDS22321.1 [Q9D3X9-1] CCDS80877.1 [Q9D3X9-2] |
RefSeqi | NP_001171352.1, NM_001177881.1 [Q9D3X9-1] NP_001171353.1, NM_001177882.1 [Q9D3X9-1] NP_001280698.1, NM_001293769.1 [Q9D3X9-2] NP_082032.1, NM_027756.5 [Q9D3X9-1] |
3D structure databases
SMRi | Q9D3X9 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9D3X9, 1 interactor |
STRINGi | 10090.ENSMUSP00000125139 |
PTM databases
GlyGeni | Q9D3X9, 5 sites |
iPTMneti | Q9D3X9 |
PhosphoSitePlusi | Q9D3X9 |
SwissPalmi | Q9D3X9 |
Proteomic databases
PaxDbi | Q9D3X9 |
PeptideAtlasi | Q9D3X9 |
PRIDEi | Q9D3X9 |
Protocols and materials databases
Antibodypediai | 17138, 97 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034066; ENSMUSP00000034066; ENSMUSG00000031647 [Q9D3X9-1] ENSMUST00000160719; ENSMUSP00000125139; ENSMUSG00000031647 [Q9D3X9-1] ENSMUST00000161421; ENSMUSP00000124136; ENSMUSG00000031647 [Q9D3X9-2] ENSMUST00000161702; ENSMUSP00000124330; ENSMUSG00000031647 [Q9D3X9-1] |
GeneIDi | 71306 |
KEGGi | mmu:71306 |
UCSCi | uc009ltf.3, mouse [Q9D3X9-1] |
Organism-specific databases
CTDi | 9848 |
MGIi | MGI:1918556, Mfap3l |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502QW9J, Eukaryota |
GeneTreei | ENSGT00390000011576 |
HOGENOMi | CLU_056017_2_0_1 |
InParanoidi | Q9D3X9 |
OMAi | GQNFVRQ |
OrthoDBi | 1154642at2759 |
PhylomeDBi | Q9D3X9 |
TreeFami | TF333205 |
Miscellaneous databases
BioGRID-ORCSi | 71306, 0 hits in 17 CRISPR screens |
ChiTaRSi | Mfap3l, mouse |
PROi | PR:Q9D3X9 |
RNActi | Q9D3X9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031647, Expressed in lacrimal gland and 249 other tissues |
Genevisiblei | Q9D3X9, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR039696, MFAP3-like |
PANTHERi | PTHR14340, PTHR14340, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MFA3L_MOUSE | |
Accessioni | Q9D3X9Primary (citable) accession number: Q9D3X9 Secondary accession number(s): Q80TV6, Q8BJA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot