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Protein

Transcription initiation factor TFIID subunit 7-like

Gene

Taf7l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably functions as a spermatogensis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 7-like
Alternative name(s):
TATA box binding protein-associated factor RNA polymerase II subunit Q
TATA box-binding protein-associated factor 50 kDa
Transcription initiation factor TFIID 50 kDa subunit
Gene namesi
Name:Taf7l
Synonyms:Taf2q
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1921719 Taf7l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduced sperm count and motility.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078621 – 471Transcription initiation factor TFIID subunit 7-likeAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei199PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D3R9
PRIDEiQ9D3R9

PTM databases

iPTMnetiQ9D3R9
PhosphoSitePlusiQ9D3R9

Expressioni

Tissue specificityi

Testis-specific (at protein level). Expressed during spermatogenesis from spermatogonia stage up to the stage of round spermatids.2 Publications

Gene expression databases

BgeeiENSMUSG00000009596 Expressed in 32 organ(s), highest expression level in placenta
ExpressionAtlasiQ9D3R9 baseline and differential
GenevisibleiQ9D3R9 MM

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TAF7L may replace TAF7 in a spermatogenesis-specific form of TFIID. Interacts with TBP; the interaction occurs in a sub-population of cells (pachytene and haploid round spermatids) and is developmentally regulated through differential intracellular localization of the two proteins. Interacts with TAF1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216775, 1 interactor
CORUMiQ9D3R9
STRINGi10090.ENSMUSP00000009740

Structurei

3D structure databases

ProteinModelPortaliQ9D3R9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili358 – 433Sequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the TAF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4011 Eukaryota
COG5414 LUCA
GeneTreeiENSGT00390000010815
HOGENOMiHOG000035121
HOVERGENiHBG013606
InParanoidiQ9D3R9
KOiK03132
OrthoDBiEOG091G0S3N
PhylomeDBiQ9D3R9
TreeFamiTF313044

Family and domain databases

CDDicd08047 TAF7, 1 hit
InterProiView protein in InterPro
IPR037817 TAF7
IPR006751 TAFII55_prot_cons_reg
PANTHERiPTHR12228 PTHR12228, 1 hit
PfamiView protein in Pfam
PF04658 TAFII55_N, 1 hit
SMARTiView protein in SMART
SM01370 TAFII55_N, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D3R9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERGEEAPTE GAPPEGALVE AKAPVIPEAP ATDVSTTEEA GSKEPQVPSG
60 70 80 90 100
PRPEGAGDTC DTRGARGPPT PGRAKSQKTP RQGTARCQTL ESAMRSMSVR
110 120 130 140 150
LECHDVEEQF ILRLPPEQAY AVRKIIHSRN AAWKDKLKID FSPDGHHAVV
160 170 180 190 200
QVDNVSLPAK LVNLPCVIGS LKTIDRKTFY KTADVSQMLV CSPEGEPHSP
210 220 230 240 250
PEEPVVSTGP TVIGISEGKA ERKKYNWKHG ITPPLKNVRK KRFRKTTKKL
260 270 280 290 300
PDVKQVDEIN FSEYTQSPSV EKEVKRLLYS DAEAVSVRWE VVDDDDAKEI
310 320 330 340 350
ESQGSMPTTP GISQMGGASL SDYDVFREMM GDSGSNSNDV EEKSNEGDDD
360 370 380 390 400
DDEDEDDEDY GNEKEEEETD NSEEELEKEL QAKFNEFSLH EADQDYSSIT
410 420 430 440 450
MAIQKLIFIK EKRLQMIYKK AQRQKELLRK VENLTLKRHF QNVLGKLNIM
460 470
EKEKCEQIYH LQEQLKCFLK E
Length:471
Mass (Da):52,905
Last modified:October 23, 2007 - v2
Checksum:iB7137077480EFB18
GO
Isoform 2 (identifier: Q9D3R9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.

Show »
Length:378
Mass (Da):43,461
Checksum:i7AAA642B78E4F39E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AV36B1AV36_MOUSE
Transcription initiation factor TFI...
Taf7l
350Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15E → D in BAB30600 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0288491 – 93Missing in isoform 2. 2 PublicationsAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285574 mRNA Translation: AAK31953.1
AK017109 mRNA Translation: BAB30600.1
AL672064 Genomic DNA No translation available.
BC106854 mRNA Translation: AAI06855.1
CCDSiCCDS53184.1 [Q9D3R9-1]
RefSeqiNP_083234.2, NM_028958.4 [Q9D3R9-1]
UniGeneiMm.103259

Genome annotation databases

EnsembliENSMUST00000009740; ENSMUSP00000009740; ENSMUSG00000009596 [Q9D3R9-1]
GeneIDi74469
KEGGimmu:74469
UCSCiuc009ugc.2 mouse [Q9D3R9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285574 mRNA Translation: AAK31953.1
AK017109 mRNA Translation: BAB30600.1
AL672064 Genomic DNA No translation available.
BC106854 mRNA Translation: AAI06855.1
CCDSiCCDS53184.1 [Q9D3R9-1]
RefSeqiNP_083234.2, NM_028958.4 [Q9D3R9-1]
UniGeneiMm.103259

3D structure databases

ProteinModelPortaliQ9D3R9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216775, 1 interactor
CORUMiQ9D3R9
STRINGi10090.ENSMUSP00000009740

PTM databases

iPTMnetiQ9D3R9
PhosphoSitePlusiQ9D3R9

Proteomic databases

PaxDbiQ9D3R9
PRIDEiQ9D3R9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009740; ENSMUSP00000009740; ENSMUSG00000009596 [Q9D3R9-1]
GeneIDi74469
KEGGimmu:74469
UCSCiuc009ugc.2 mouse [Q9D3R9-1]

Organism-specific databases

CTDi54457
MGIiMGI:1921719 Taf7l

Phylogenomic databases

eggNOGiKOG4011 Eukaryota
COG5414 LUCA
GeneTreeiENSGT00390000010815
HOGENOMiHOG000035121
HOVERGENiHBG013606
InParanoidiQ9D3R9
KOiK03132
OrthoDBiEOG091G0S3N
PhylomeDBiQ9D3R9
TreeFamiTF313044

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

PROiPR:Q9D3R9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009596 Expressed in 32 organ(s), highest expression level in placenta
ExpressionAtlasiQ9D3R9 baseline and differential
GenevisibleiQ9D3R9 MM

Family and domain databases

CDDicd08047 TAF7, 1 hit
InterProiView protein in InterPro
IPR037817 TAF7
IPR006751 TAFII55_prot_cons_reg
PANTHERiPTHR12228 PTHR12228, 1 hit
PfamiView protein in Pfam
PF04658 TAFII55_N, 1 hit
SMARTiView protein in SMART
SM01370 TAFII55_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAF7L_MOUSE
AccessioniPrimary (citable) accession number: Q9D3R9
Secondary accession number(s): A2AFB9, Q99MW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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