UniProtKB - Q9D3R6 (KATL2_MOUSE)
Protein
Katanin p60 ATPase-containing subunit A-like 2
Gene
Katnal2
Organism
Mus musculus (Mouse)
Status
Functioni
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.UniRule annotation
Catalytic activityi
- n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.UniRule annotation EC:5.6.1.1
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 295 – 302 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- isomerase activity Source: UniProtKB-KW
- microtubule binding Source: UniProtKB-UniRule
- microtubule-severing ATPase activity Source: GO_Central
GO - Biological processi
- cytoplasmic microtubule organization Source: GO_Central
Keywordsi
Molecular function | Isomerase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Katanin p60 ATPase-containing subunit A-like 2UniRule annotation (EC:5.6.1.1UniRule annotation)Short name: Katanin p60 subunit A-like 2UniRule annotation Alternative name(s): p60 katanin-like 2UniRule annotation |
Gene namesi | Name:Katnal2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1924234, Katnal2 |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotation
- spindle By similarity
- spindle pole By similarity
Other locations
- Cytoplasm By similarity
Note: Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.By similarity
Cytoskeleton
- microtubule Source: UniProtKB
- spindle Source: UniProtKB
- spindle pole Source: UniProtKB
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000333793 | 1 – 539 | Katanin p60 ATPase-containing subunit A-like 2Add BLAST | 539 |
Proteomic databases
jPOSTi | Q9D3R6 |
PaxDbi | Q9D3R6 |
PRIDEi | Q9D3R6 |
PTM databases
iPTMneti | Q9D3R6 |
PhosphoSitePlusi | Q9D3R6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025420, Expressed in spermatid and 148 other tissues |
ExpressionAtlasi | Q9D3R6, baseline and differential |
Genevisiblei | Q9D3R6, MM |
Interactioni
GO - Molecular functioni
- microtubule binding Source: UniProtKB-UniRule
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026486 |
Miscellaneous databases
RNActi | Q9D3R6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 57 | LisHUniRule annotationAdd BLAST | 33 |
Sequence similaritiesi
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0738, Eukaryota |
GeneTreei | ENSGT00940000157302 |
HOGENOMi | CLU_000688_21_1_1 |
InParanoidi | Q9D3R6 |
OrthoDBi | 787710at2759 |
PhylomeDBi | Q9D3R6 |
TreeFami | TF329610 |
Family and domain databases
HAMAPi | MF_03025, Katanin_p60_AL2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR027497, Katanin_p60_AL2 IPR006594, LisH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00667, LisH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9D3R6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELSYQTLKL THQAREAYEM RTEARRKNLL ILILHYLTQE GYMDAAKALE
60 70 80 90 100
EETKLGLRRF EVCDNVDLET ILMEYESYYF VKFQKYPKVV KKAPDPVENN
110 120 130 140 150
LPSRSGGKNK RLTNDSCQNL PKICHQKSRP KTSAVKTGDT KSVKEHLKQV
160 170 180 190 200
KESVTDTQAE STDFGLNISK IHKDQPEEKA QPRRGQIIDF RGLLSDAIKG
210 220 230 240 250
ATSEFALNTF ECNPDPSERL LKPLSAFIGM NSEMRELAAV VSRDIYLHNP
260 270 280 290 300
NIKWNDIIGL DAAKQLVKEA VVYPIRYPQL FTGILSPWKG LLLYGPPGTG
310 320 330 340 350
KTLLAKAVAT ECKTTFFNIS ASTIVSKWRG DSEKLVRVLF ELARYHAPST
360 370 380 390 400
IFLDELESVM SQRGMVPGGE HEGSLRMKTE LLVQMDGLAR SEDLVFVLAA
410 420 430 440 450
SNLPWELDCA MLRRLEKRIL VDLPSQEARQ AMIYHWLPPV SKNHALELHT
460 470 480 490 500
QLEYSVLSQE TEGYSGSDIK LVCREAAMRP VRKIFSVLEN NQSESNNLPG
510 520 530
IQLDTVTTQD FLDVLAHTKP SAKNLTERYL AWQEKFESV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z4J2 | D3Z4J2_MOUSE | Katanin p60 ATPase-containing subun... | Katnal2 KATNAL2 | 495 | Annotation score: | ||
D6RGM7 | D6RGM7_MOUSE | Katanin p60 ATPase-containing subun... | Katnal2 | 372 | Annotation score: | ||
D3Z0U5 | D3Z0U5_MOUSE | Katanin p60 ATPase-containing subun... | Katnal2 | 277 | Annotation score: | ||
D3Z087 | D3Z087_MOUSE | Katanin p60 ATPase-containing subun... | Katnal2 | 85 | Annotation score: | ||
D6RI39 | D6RI39_MOUSE | Katanin p60 ATPase-containing subun... | Katnal2 | 39 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033524 | 150 – 151 | Missing in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_033525 | 185 – 219 | GQIID…DPSER → VSGAQGPRMERGTCLKKKEN KAYSCCQTGKRRQKH in isoform 2. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_033526 | 220 – 539 | Missing in isoform 2. 1 PublicationAdd BLAST | 320 | |
Alternative sequenceiVSP_033527 | 407 – 409 | LDC → GDA in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_033528 | 410 – 539 | Missing in isoform 3. 1 PublicationAdd BLAST | 130 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK017114 mRNA Translation: BAB30604.1 AC132608 Genomic DNA No translation available. BC069977 mRNA Translation: AAH69977.1 |
CCDSi | CCDS37865.1 [Q9D3R6-3] CCDS89281.1 [Q9D3R6-1] |
RefSeqi | NP_081997.1, NM_027721.2 [Q9D3R6-3] XP_006526500.1, XM_006526437.3 |
Genome annotation databases
Ensembli | ENSMUST00000026486; ENSMUSP00000026486; ENSMUSG00000025420 [Q9D3R6-3] ENSMUST00000126153; ENSMUSP00000122079; ENSMUSG00000025420 [Q9D3R6-1] ENSMUST00000154665; ENSMUSP00000119066; ENSMUSG00000025420 [Q9D3R6-2] |
GeneIDi | 71206 |
UCSCi | uc008fqx.1, mouse [Q9D3R6-3] uc008fqz.1, mouse [Q9D3R6-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK017114 mRNA Translation: BAB30604.1 AC132608 Genomic DNA No translation available. BC069977 mRNA Translation: AAH69977.1 |
CCDSi | CCDS37865.1 [Q9D3R6-3] CCDS89281.1 [Q9D3R6-1] |
RefSeqi | NP_081997.1, NM_027721.2 [Q9D3R6-3] XP_006526500.1, XM_006526437.3 |
3D structure databases
SMRi | Q9D3R6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026486 |
PTM databases
iPTMneti | Q9D3R6 |
PhosphoSitePlusi | Q9D3R6 |
Proteomic databases
jPOSTi | Q9D3R6 |
PaxDbi | Q9D3R6 |
PRIDEi | Q9D3R6 |
Protocols and materials databases
Antibodypediai | 22528, 57 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026486; ENSMUSP00000026486; ENSMUSG00000025420 [Q9D3R6-3] ENSMUST00000126153; ENSMUSP00000122079; ENSMUSG00000025420 [Q9D3R6-1] ENSMUST00000154665; ENSMUSP00000119066; ENSMUSG00000025420 [Q9D3R6-2] |
GeneIDi | 71206 |
UCSCi | uc008fqx.1, mouse [Q9D3R6-3] uc008fqz.1, mouse [Q9D3R6-2] |
Organism-specific databases
CTDi | 83473 |
MGIi | MGI:1924234, Katnal2 |
Phylogenomic databases
eggNOGi | KOG0738, Eukaryota |
GeneTreei | ENSGT00940000157302 |
HOGENOMi | CLU_000688_21_1_1 |
InParanoidi | Q9D3R6 |
OrthoDBi | 787710at2759 |
PhylomeDBi | Q9D3R6 |
TreeFami | TF329610 |
Miscellaneous databases
BioGRID-ORCSi | 71206, 0 hits in 12 CRISPR screens |
ChiTaRSi | Katnal2, mouse |
PROi | PR:Q9D3R6 |
RNActi | Q9D3R6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025420, Expressed in spermatid and 148 other tissues |
ExpressionAtlasi | Q9D3R6, baseline and differential |
Genevisiblei | Q9D3R6, MM |
Family and domain databases
HAMAPi | MF_03025, Katanin_p60_AL2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR027497, Katanin_p60_AL2 IPR006594, LisH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00667, LisH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KATL2_MOUSE | |
Accessioni | Q9D3R6Primary (citable) accession number: Q9D3R6 Secondary accession number(s): Q6NSQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families