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Protein

Centrosomal protein of 72 kDa

Gene

Cep72

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (By similarity). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 72 kDa
Short name:
Cep72
Gene namesi
Name:Cep72
Synonyms:Kiaa1519
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1921720 Cep72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895001 – 646Centrosomal protein of 72 kDaAdd BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineCombined sources1
Modified residuei236PhosphoserineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei402PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D3R3
PeptideAtlasiQ9D3R3
PRIDEiQ9D3R3

PTM databases

iPTMnetiQ9D3R3
PhosphoSitePlusiQ9D3R3

Expressioni

Gene expression databases

BgeeiENSMUSG00000021572 Expressed in 91 organ(s), highest expression level in testis
CleanExiMM_CEP72
ExpressionAtlasiQ9D3R3 baseline and differential
GenevisibleiQ9D3R3 MM

Interactioni

Subunit structurei

Interacts with KIZ, PCM1 and CDK5RAP2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216776, 53 interactors
IntActiQ9D3R3, 52 interactors
MINTiQ9D3R3
STRINGi10090.ENSMUSP00000037788

Structurei

3D structure databases

ProteinModelPortaliQ9D3R3
SMRiQ9D3R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 49LRR 1Add BLAST22
Repeati54 – 75LRR 2Add BLAST22
Repeati76 – 97LRR 3Add BLAST22
Domaini110 – 149LRRCTAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili476 – 622Sequence analysisAdd BLAST147

Sequence similaritiesi

Belongs to the CEP72 family.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IH75 Eukaryota
ENOG4111P3A LUCA
GeneTreeiENSGT00530000063884
HOVERGENiHBG050900
InParanoidiQ9D3R3
KOiK16532
OMAiAEVEQMH
OrthoDBiEOG091G04WS
TreeFamiTF338646

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00369 LRR_TYP, 2 hits
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D3R3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPGQRLVLC EETVRERSGL GPHRDLAELR SLSIPGTYQE KITHLGNSLM
60 70 80 90 100
HLTALKSLDL SRNSLVSLEG IQYLVSLESL NLYYNCISSL AEVFRLHTLL
110 120 130 140 150
ELQDVDFRLN PVVKNESDYR LFVVHMLPKL RQLDDRPVRE SERKASQLHF
160 170 180 190 200
APEDSLNSKE NFSTTLTVGR PHHLRNRCTE TSAKKCLVMD ADDEAVLNLI
210 220 230 240 250
AECEWDLSNP PGNMSSSQKE HEADLHYAQE SRHLLSPLSI QHQCGDSARR
260 270 280 290 300
GHEKKKVTSR GCPGHSPQDQ LCGELPLQHG LPEACHMHVQ HARITSQPDS
310 320 330 340 350
VDVEDCASSA QKSSLSSQKT VNPLPVPEKY RKRRMPGGRF QVPSDRECLS
360 370 380 390 400
FLERADGPSS LEDSLSRQDG LEGQSQVALS HSEALEAEER TSHGTSDPRV
410 420 430 440 450
LSPKLCSAAV PERRSTLEVA LLEALLDLID RCSSGSGSLH GNEAFLAQAK
460 470 480 490 500
HVLSSLQEFT ATRDSSALEK EGIGYLSLEN KTLQSRLAEQ QQQYTATVTK
510 520 530 540 550
MTAELNNTKR ELDTLRQHLD KSLEENSHLK SLLYNVKKEV KTADTSTALT
560 570 580 590 600
LQITGLQASM KQLSGEVVEL KQHVEHYDKI QELTQMLQES HSSLVSTNEH
610 620 630 640
LLQELSRTRA QHRAEVEQMR WSFQEFKKTT ALIPHRSSRR GGRQSC
Length:646
Mass (Da):72,433
Last modified:July 27, 2011 - v3
Checksum:i9E2A803B0E0883AC
GO
Isoform 2 (identifier: Q9D3R3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-286: Missing.
     321-400: Missing.

Show »
Length:280
Mass (Da):31,339
Checksum:iA0285EE855EB5826
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJU1A0A1Y7VJU1_MOUSE
Centrosomal protein of 72 kDa
Cep72
470Annotation score:
A0A1Y7VNL4A0A1Y7VNL4_MOUSE
Centrosomal protein of 72 kDa
Cep72
295Annotation score:
A0A1Y7VMX8A0A1Y7VMX8_MOUSE
Centrosomal protein of 72 kDa
Cep72
141Annotation score:
A0A1Y7VNS5A0A1Y7VNS5_MOUSE
Centrosomal protein of 72 kDa
Cep72
51Annotation score:

Sequence cautioni

The sequence BAC28870 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32467 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 19SG → RA in BAB30613 (PubMed:16141072).Curated2
Sequence conflicti301V → L in BAB27729 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0127481 – 286Missing in isoform 2. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_012749321 – 400Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011607 mRNA Translation: BAB27729.1
AK017134 mRNA Translation: BAB30613.2
AK034892 mRNA Translation: BAC28870.1 Different initiation.
AK161033 mRNA Translation: BAE36159.1
CT010471 Genomic DNA No translation available.
BC100549 mRNA Translation: AAI00550.1
AK173189 Transcribed RNA Translation: BAD32467.1 Sequence problems.
CCDSiCCDS26639.1 [Q9D3R3-1]
RefSeqiNP_083235.3, NM_028959.3 [Q9D3R3-1]
UniGeneiMm.73234

Genome annotation databases

EnsembliENSMUST00000036456; ENSMUSP00000037788; ENSMUSG00000021572 [Q9D3R3-1]
GeneIDi74470
KEGGimmu:74470
UCSCiuc007rep.2 mouse [Q9D3R3-2]
uc007req.2 mouse [Q9D3R3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011607 mRNA Translation: BAB27729.1
AK017134 mRNA Translation: BAB30613.2
AK034892 mRNA Translation: BAC28870.1 Different initiation.
AK161033 mRNA Translation: BAE36159.1
CT010471 Genomic DNA No translation available.
BC100549 mRNA Translation: AAI00550.1
AK173189 Transcribed RNA Translation: BAD32467.1 Sequence problems.
CCDSiCCDS26639.1 [Q9D3R3-1]
RefSeqiNP_083235.3, NM_028959.3 [Q9D3R3-1]
UniGeneiMm.73234

3D structure databases

ProteinModelPortaliQ9D3R3
SMRiQ9D3R3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216776, 53 interactors
IntActiQ9D3R3, 52 interactors
MINTiQ9D3R3
STRINGi10090.ENSMUSP00000037788

PTM databases

iPTMnetiQ9D3R3
PhosphoSitePlusiQ9D3R3

Proteomic databases

PaxDbiQ9D3R3
PeptideAtlasiQ9D3R3
PRIDEiQ9D3R3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036456; ENSMUSP00000037788; ENSMUSG00000021572 [Q9D3R3-1]
GeneIDi74470
KEGGimmu:74470
UCSCiuc007rep.2 mouse [Q9D3R3-2]
uc007req.2 mouse [Q9D3R3-1]

Organism-specific databases

CTDi55722
MGIiMGI:1921720 Cep72
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IH75 Eukaryota
ENOG4111P3A LUCA
GeneTreeiENSGT00530000063884
HOVERGENiHBG050900
InParanoidiQ9D3R3
KOiK16532
OMAiAEVEQMH
OrthoDBiEOG091G04WS
TreeFamiTF338646

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

PROiPR:Q9D3R3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021572 Expressed in 91 organ(s), highest expression level in testis
CleanExiMM_CEP72
ExpressionAtlasiQ9D3R3 baseline and differential
GenevisibleiQ9D3R3 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00369 LRR_TYP, 2 hits
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCEP72_MOUSE
AccessioniPrimary (citable) accession number: Q9D3R3
Secondary accession number(s): E9QQ95
, Q3TU12, Q497H8, Q69ZH7, Q8BM53, Q9D0B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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