UniProtKB - Q9D3G5 (STX11_MOUSE)
Protein
Syntaxin-11
Gene
Stx11
Organism
Mus musculus (Mouse)
Status
Functioni
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.By similarity
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- cellular response to interferon-gamma Source: MGI
- cytotoxic T cell degranulation Source: MGI
- exocytosis Source: GO_Central
- intracellular protein transport Source: GO_Central
- natural killer cell degranulation Source: MGI
- natural killer cell mediated cytotoxicity Source: MGI
- neutrophil degranulation Source: MGI
- synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
- T cell mediated cytotoxicity Source: MGI
- vesicle docking Source: GO_Central
- vesicle fusion Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-11 |
Gene namesi | Name:Stx11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921982, Stx11 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane By similarity; Peripheral membrane protein By similarity
Other locations
- Membrane Curated; Peripheral membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
- presynaptic active zone membrane Source: GO_Central
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: GO_Central
- phagocytic vesicle Source: MGI
- SNARE complex Source: GO_Central
- synaptic vesicle Source: GO_Central
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210222 | 1 – 287 | Syntaxin-11Add BLAST | 287 |
Proteomic databases
EPDi | Q9D3G5 |
MaxQBi | Q9D3G5 |
PaxDbi | Q9D3G5 |
PRIDEi | Q9D3G5 |
ProteomicsDBi | 254606 |
PTM databases
iPTMneti | Q9D3G5 |
PhosphoSitePlusi | Q9D3G5 |
SwissPalmi | Q9D3G5 |
Interactioni
Subunit structurei
Interacts with the SNARE proteins SNAP-23 and VAMP.
By similarityGO - Molecular functioni
- SNARE binding Source: GO_Central
Protein-protein interaction databases
IntActi | Q9D3G5, 1 interactor |
STRINGi | 10090.ENSMUSP00000046243 |
Miscellaneous databases
RNActi | Q9D3G5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 204 – 266 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 41 – 71 | Sequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the syntaxin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0810, Eukaryota |
InParanoidi | Q9D3G5 |
OrthoDBi | 1033833at2759 |
PhylomeDBi | Q9D3G5 |
Family and domain databases
CDDi | cd15878, SNARE_syntaxin11, 1 hit cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR028672, STX11 IPR006012, Syntaxin/epimorphin_CS IPR042781, Syntaxin11_SNARE IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF30, PTHR19957:SF30, 1 hit |
Pfami | View protein in Pfam PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9D3G5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDRLAELQE LSRSYDQQFP DGDNDFDAPR EDIVFETDNI LESLYRVIQD
60 70 80 90 100
IQDENQLLLI DVRRLGRQNV RFLTSMRRLS SIKRDTNSIA KAIKTRGEGI
110 120 130 140 150
HQKLRSMKEL SEQAEARHGA HSAVARISHA QYSALARAFQ QAMYEYNQAE
160 170 180 190 200
MKQRDNCKIR IQRQLEIMGK DMSGEQIEDM FEQGKWDVFS ENLLADLKGA
210 220 230 240 250
RAALNEIESR HRELLRLEGR IRDVHELFLQ MAVLVEKQED TLNVIELNVQ
260 270 280
KTLDYTGEAK AQVRKAVQYK KKNPCRTICC FCCPCVN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3U5V8 | Q3U5V8_MOUSE | Syntaxin-11 | Stx11 | 287 | Annotation score: | ||
A0A1W2P6Y3 | A0A1W2P6Y3_MOUSE | Syntaxin-11 | Stx11 | 84 | Annotation score: | ||
A0A1W2P6E3 | A0A1W2P6E3_MOUSE | Syntaxin-11 | Stx11 | 50 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK017897 mRNA Translation: BAB30994.1 |
CCDSi | CCDS48500.1 |
RefSeqi | NP_083351.1, NM_029075.1 |
Genome annotation databases
GeneIDi | 74732 |
KEGGi | mmu:74732 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK017897 mRNA Translation: BAB30994.1 |
CCDSi | CCDS48500.1 |
RefSeqi | NP_083351.1, NM_029075.1 |
3D structure databases
SMRi | Q9D3G5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9D3G5, 1 interactor |
STRINGi | 10090.ENSMUSP00000046243 |
PTM databases
iPTMneti | Q9D3G5 |
PhosphoSitePlusi | Q9D3G5 |
SwissPalmi | Q9D3G5 |
Proteomic databases
EPDi | Q9D3G5 |
MaxQBi | Q9D3G5 |
PaxDbi | Q9D3G5 |
PRIDEi | Q9D3G5 |
ProteomicsDBi | 254606 |
Genome annotation databases
GeneIDi | 74732 |
KEGGi | mmu:74732 |
Organism-specific databases
CTDi | 8676 |
MGIi | MGI:1921982, Stx11 |
Phylogenomic databases
eggNOGi | KOG0810, Eukaryota |
InParanoidi | Q9D3G5 |
OrthoDBi | 1033833at2759 |
PhylomeDBi | Q9D3G5 |
Miscellaneous databases
BioGRID-ORCSi | 74732, 1 hit in 52 CRISPR screens |
PROi | PR:Q9D3G5 |
RNActi | Q9D3G5, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd15878, SNARE_syntaxin11, 1 hit cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR028672, STX11 IPR006012, Syntaxin/epimorphin_CS IPR042781, Syntaxin11_SNARE IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF30, PTHR19957:SF30, 1 hit |
Pfami | View protein in Pfam PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STX11_MOUSE | |
Accessioni | Q9D3G5Primary (citable) accession number: Q9D3G5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families