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Protein

SLAM family member 8

Gene

Slamf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.1 Publication

GO - Molecular functioni

  • identical protein binding Source: MGI
  • signaling receptor activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SLAM family member 8
Alternative name(s):
B-lymphocyte activator macrophage expressed
CD_antigen: CD353
Gene namesi
Name:Slamf8
Synonyms:Blame
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921998 Slamf8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 231ExtracellularSequence analysisAdd BLAST211
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 278CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001496621 – 278SLAM family member 8Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi150 ↔ 199PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9D3G2
PRIDEiQ9D3G2

Expressioni

Gene expression databases

CleanExiMM_SLAMF8

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067527

Structurei

3D structure databases

ProteinModelPortaliQ9D3G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 213Ig-like C2-typeAdd BLAST88

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVMT Eukaryota
ENOG410Y74Q LUCA
HOGENOMiHOG000133036
HOVERGENiHBG083118
InParanoidiQ9D3G2
KOiK16853
PhylomeDBiQ9D3G2

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D3G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWSLWSLLLF EALLPVVVVS VQVLSKVGDS ELLVAECPPG FQVREAIWRS
60 70 80 90 100
LWPSEELLAT FFRGSLETLY HSRFLGRVQL YDNLSLELGP LKPGDSGNFS
110 120 130 140 150
VLMVDTGGQT WTQTLYLKVY DAVPKPEVQV FTAAAEETQP LNTCQVFLSC
160 170 180 190 200
WAPNISDITY SWRWEGTVDF NGEVRSHFSN GQVLSVSLGL GDKDVAFTCI
210 220 230 240 250
ASNPVSWDMT TVTPWESCHH EAASGKASYK DVLLVVVPIT LFLILAGLFG
260 270
AWHHGLCSGK KKDACTDGVL PETENALV
Length:278
Mass (Da):30,646
Last modified:June 7, 2005 - v2
Checksum:i7E33B1D9E010EB0A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UQA2Q3UQA2_MOUSE
SLAM family member 8
Slamf8
278Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107G → R in BAB30999 (PubMed:16141072).Curated1
Sequence conflicti164W → R in BAB30999 (PubMed:16141072).Curated1
Sequence conflicti175R → H in BAB30999 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017911 mRNA Translation: BAB30999.1
BC024587 mRNA Translation: AAH24587.1
CCDSiCCDS15517.1
RefSeqiNP_083360.2, NM_029084.3
UniGeneiMm.179812

Genome annotation databases

GeneIDi74748
KEGGimmu:74748

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017911 mRNA Translation: BAB30999.1
BC024587 mRNA Translation: AAH24587.1
CCDSiCCDS15517.1
RefSeqiNP_083360.2, NM_029084.3
UniGeneiMm.179812

3D structure databases

ProteinModelPortaliQ9D3G2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067527

Proteomic databases

PaxDbiQ9D3G2
PRIDEiQ9D3G2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi74748
KEGGimmu:74748

Organism-specific databases

CTDi56833
MGIiMGI:1921998 Slamf8

Phylogenomic databases

eggNOGiENOG410IVMT Eukaryota
ENOG410Y74Q LUCA
HOGENOMiHOG000133036
HOVERGENiHBG083118
InParanoidiQ9D3G2
KOiK16853
PhylomeDBiQ9D3G2

Miscellaneous databases

PROiPR:Q9D3G2
SOURCEiSearch...

Gene expression databases

CleanExiMM_SLAMF8

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLAF8_MOUSE
AccessioniPrimary (citable) accession number: Q9D3G2
Secondary accession number(s): Q8R3T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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