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Protein

Cohesin subunit SA-1

Gene

Stag1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2467813 Separation of Sister Chromatids
R-MMU-2468052 Establishment of Sister Chromatid Cohesion
R-MMU-2470946 Cohesin Loading onto Chromatin
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Cohesin subunit SA-1
Alternative name(s):
SCC3 homolog 1
Stromal antigen 1
Gene namesi
Name:Stag1
Synonyms:Sa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1098658 Stag1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201831 – 1258Cohesin subunit SA-1Add BLAST1258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1
Modified residuei756PhosphoserineBy similarity1
Modified residuei1062PhosphoserineCombined sources1
Modified residuei1065PhosphoserineCombined sources1
Modified residuei1093PhosphoserineBy similarity1
Cross-linki1161Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D3E6
MaxQBiQ9D3E6
PaxDbiQ9D3E6
PeptideAtlasiQ9D3E6
PRIDEiQ9D3E6

PTM databases

iPTMnetiQ9D3E6
PhosphoSitePlusiQ9D3E6

Expressioni

Gene expression databases

BgeeiENSMUSG00000037286 Expressed in 295 organ(s), highest expression level in midbrain
CleanExiMM_STAG1
ExpressionAtlasiQ9D3E6 baseline and differential
GenevisibleiQ9D3E6 MM

Interactioni

Subunit structurei

Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG1 is mutually exclusive with STAG2 and STAG3. Interacts directly with RAD21 in cohesin complex. Found in a cohesin complex with SMC1A, SMC3 and RAD21.By similarity

Protein-protein interaction databases

BioGridi203517, 3 interactors
IntActiQ9D3E6, 3 interactors
MINTiQ9D3E6
STRINGi10090.ENSMUSP00000116205

Structurei

3D structure databases

ProteinModelPortaliQ9D3E6
SMRiQ9D3E6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini296 – 381SCDPROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the SCC3 family.Curated

Phylogenomic databases

eggNOGiKOG2011 Eukaryota
COG5537 LUCA
GeneTreeiENSGT00390000014094
HOGENOMiHOG000231375
HOVERGENiHBG057636
InParanoidiQ9D3E6
KOiK06671
OrthoDBiEOG091G0195
PhylomeDBiQ9D3E6
TreeFamiTF314604

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039662 Cohesin_Scc3/SA
IPR020839 SCD
IPR013721 STAG
PANTHERiPTHR11199 PTHR11199, 1 hit
PfamiView protein in Pfam
PF08514 STAG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51425 SCD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q9D3E6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITSELPVLQ DSTNETTAHS DAGSELEETE VKGKRKRGRP GRPPSTNKKP
60 70 80 90 100
RKSPGEKSRI EAGIRGAGRG RANGHPQQNG DGDPVTLFEV VKLGKSAMQS
110 120 130 140 150
VVDDWIELYK QDRDIALLDL INFFIQCSGC RGTVRIEMFR NMQNAEIIRK
160 170 180 190 200
MTEEFDEDSG DYPLTMPGPQ WKKFRSNFCE FIGVLIRQCQ YSIIYDEYMM
210 220 230 240 250
DTVISLLTGL SDSQVRAFRH TSTLAAMKLM TALVNVALNL SIHQDNTQRQ
260 270 280 290 300
YEAERNKMIG KRANERLELL LQKRKELQEN QDEIENMMNS IFKGIFVHRY
310 320 330 340 350
RDAIAEIRAI CIEEIGVWMK MYSDAFLNDS YLKYVGWTLH DRQGEVRLKC
360 370 380 390 400
LKALQSLYTN RELFPKLELF TNRFKDRIVS MTLDKEYDVA VEAIRLVTLI
410 420 430 440 450
LHGSEEALSN EDCENVYHLV YSAHRPVAVA AGEFLHKKLF SRHDPQAEEA
460 470 480 490 500
LAKRRGRNSP NGNLIRMLVL FFLESELHEH AAYLVDSLWE SSQELLKDWE
510 520 530 540 550
CMTELLLEEP VQGEEAMSDR QESALIELMV CTIRQAAEAH PPVGRGTGKR
560 570 580 590 600
VLTAKERKTQ IDDRNKLTEH FIITLPMLLS KYSADAEKVA NLLQIPQYFD
610 620 630 640 650
LEIYSTGRME KHLDALLKQI KFVVEKHVES DVLEACSKTY SILCSEEYTI
660 670 680 690 700
QNRVDIARSQ LIDEFVDRFN HSVEDLLQEG EEADDDDIYN VLSTLKRLTS
710 720 730 740 750
FHNAHDLTKW DLFGNCYRLL KTGIEHGAMP EQIVVQALQC SHYSILWQLV
760 770 780 790 800
KITDGSPSKE DLLVLRKTVK SFLAVCQQCL SNVNTPVKEQ AFMLLCDLLM
810 820 830 840 850
IFSHQLMTGG REGLQPLVFN PDTGLQSELL SFVMDHVFID QDEENQSMEG
860 870 880 890 900
DEEDEANKIE ALHKRRNLLA AFSKLIIYDI VDMHAAADIF KHYMKYYNDY
910 920 930 940 950
GDIIKETLSK TRQIDKIQCA KTLILSLQQL FNELVQEQGP NLDRTSAHVS
960 970 980 990 1000
GIKELARRFA LTFGLDQIKT REAVATLHKD GIEFAFKYQN QKGQEYPPPN
1010 1020 1030 1040 1050
LAFLEVLSEF SSKLLRQDKK TVHSYLEKFL TEQMMERRED VWLPLISYRN
1060 1070 1080 1090 1100
SLVTGGEDDR MSVNSGSSSS KTSSVRSKKG RPPLHRKRVE DESLDNTWLN
1110 1120 1130 1140 1150
RTDTMIQTPG PLPTPQLTST VLRENSRPMG EQIQEPESEH GSEPDFLHNP
1160 1170 1180 1190 1200
QMQISWLGQP KLEDLNRKDR TGMNYMKVRA GVRHAVRGLM EEDAEPIFED
1210 1220 1230 1240 1250
VMMSSRSQLE DMNEEFEDTM VIDLPPSRNR RERAELRPDF FDSAAIIEDD

SGFGMPMF
Length:1,258
Mass (Da):144,440
Last modified:July 27, 2011 - v3
Checksum:iE32F33609D035F9C
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHU7F8WHU7_MOUSE
Cohesin subunit SA-1
Stag1
1,221Annotation score:
D6REF2D6REF2_MOUSE
Cohesin subunit SA-1
Stag1
424Annotation score:
D6RHQ7D6RHQ7_MOUSE
Cohesin subunit SA-1
Stag1
306Annotation score:
D3Z1T1D3Z1T1_MOUSE
Cohesin subunit SA-1
Stag1
144Annotation score:
D3YYD4D3YYD4_MOUSE
Cohesin subunit SA-1
Stag1
50Annotation score:
D6RH50D6RH50_MOUSE
Cohesin subunit SA-1
Stag1
174Annotation score:
F6XQW1F6XQW1_MOUSE
Cohesin subunit SA-1
Stag1
869Annotation score:
F6TNY1F6TNY1_MOUSE
Cohesin subunit SA-1
Stag1
285Annotation score:
Q8C918Q8C918_MOUSE
Cohesin subunit SA-1
Stag1
196Annotation score:

Sequence cautioni

The sequence BAB31022 differs from that shown. Probable exon deletions within the cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 25AGSE → HGRQ in CAA99733 (PubMed:9305759).Curated4
Sequence conflicti97A → R in CAA99733 (PubMed:9305759).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75332 mRNA Translation: CAA99733.1
AK017978 mRNA Translation: BAB31022.1 Sequence problems.
BC062954 mRNA Translation: AAH62954.1
CCDSiCCDS23441.1
PIRiT30252
RefSeqiNP_033308.2, NM_009282.3
XP_006510986.1, XM_006510923.2
XP_006510987.1, XM_006510924.2
UniGeneiMm.42135

Genome annotation databases

EnsembliENSMUST00000129269; ENSMUSP00000116205; ENSMUSG00000037286
GeneIDi20842
KEGGimmu:20842
UCSCiuc009rfa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75332 mRNA Translation: CAA99733.1
AK017978 mRNA Translation: BAB31022.1 Sequence problems.
BC062954 mRNA Translation: AAH62954.1
CCDSiCCDS23441.1
PIRiT30252
RefSeqiNP_033308.2, NM_009282.3
XP_006510986.1, XM_006510923.2
XP_006510987.1, XM_006510924.2
UniGeneiMm.42135

3D structure databases

ProteinModelPortaliQ9D3E6
SMRiQ9D3E6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203517, 3 interactors
IntActiQ9D3E6, 3 interactors
MINTiQ9D3E6
STRINGi10090.ENSMUSP00000116205

PTM databases

iPTMnetiQ9D3E6
PhosphoSitePlusiQ9D3E6

Proteomic databases

EPDiQ9D3E6
MaxQBiQ9D3E6
PaxDbiQ9D3E6
PeptideAtlasiQ9D3E6
PRIDEiQ9D3E6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000129269; ENSMUSP00000116205; ENSMUSG00000037286
GeneIDi20842
KEGGimmu:20842
UCSCiuc009rfa.1 mouse

Organism-specific databases

CTDi10274
MGIiMGI:1098658 Stag1

Phylogenomic databases

eggNOGiKOG2011 Eukaryota
COG5537 LUCA
GeneTreeiENSGT00390000014094
HOGENOMiHOG000231375
HOVERGENiHBG057636
InParanoidiQ9D3E6
KOiK06671
OrthoDBiEOG091G0195
PhylomeDBiQ9D3E6
TreeFamiTF314604

Enzyme and pathway databases

ReactomeiR-MMU-2467813 Separation of Sister Chromatids
R-MMU-2468052 Establishment of Sister Chromatid Cohesion
R-MMU-2470946 Cohesin Loading onto Chromatin
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

ChiTaRSiStag1 mouse
PROiPR:Q9D3E6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037286 Expressed in 295 organ(s), highest expression level in midbrain
CleanExiMM_STAG1
ExpressionAtlasiQ9D3E6 baseline and differential
GenevisibleiQ9D3E6 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039662 Cohesin_Scc3/SA
IPR020839 SCD
IPR013721 STAG
PANTHERiPTHR11199 PTHR11199, 1 hit
PfamiView protein in Pfam
PF08514 STAG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51425 SCD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTAG1_MOUSE
AccessioniPrimary (citable) accession number: Q9D3E6
Secondary accession number(s): O08982, Q6P5D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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