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Protein

Alpha-tocopherol transfer protein-like

Gene

Ttpal

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a protein that binds a hydrophobic ligand.Curated

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-tocopherol transfer protein-like
Gene namesi
Name:Ttpal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923330 Ttpal

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107731 – 343Alpha-tocopherol transfer protein-likeAdd BLAST343

Proteomic databases

EPDiQ9D3D0
PaxDbiQ9D3D0
PeptideAtlasiQ9D3D0
PRIDEiQ9D3D0

PTM databases

iPTMnetiQ9D3D0
PhosphoSitePlusiQ9D3D0
SwissPalmiQ9D3D0

Expressioni

Gene expression databases

BgeeiENSMUSG00000017679 Expressed in 227 organ(s), highest expression level in ear
ExpressionAtlasiQ9D3D0 baseline and differential
GenevisibleiQ9D3D0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105035

Structurei

3D structure databases

ProteinModelPortaliQ9D3D0
SMRiQ9D3D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 283CRAL-TRIOPROSITE-ProRule annotationAdd BLAST166

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074253
HOGENOMiHOG000293421
HOVERGENiHBG101124
InParanoidiQ9D3D0
OMAiQCDDSMR
OrthoDBiEOG091G0KN0
PhylomeDBiQ9D3D0

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D3D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEESDSLRT SPSVASLSEN ELPLPPPDPP GYVCSLTEDL VTKAREELQE
60 70 80 90 100
KPEWRLRDVQ ALRDMVRKEY PYLSTSLDDA FLLRFLRARK FDYDRALQLL
110 120 130 140 150
VNYHGCRRSW PEVFSNLRPS ALKDVLNSGF LTVLPHTDPR GCHVLCIRPD
160 170 180 190 200
RWIPSNYPIT ENIRAVYLTL EKLIQSEETQ VNGIVILADY KGVSLSKASH
210 220 230 240 250
FGPFIAKKVI GILQDGFPIR IKAVHIVNEP RIFKGIFAII KPFLKEKIAN
260 270 280 290 300
RFFLHGSDLN SLHTNLPRNI LPKEYGGTAG ELDTASWNAV LLASEEDFVK
310 320 330 340
EFCQPMPACD NLLGQPLLPE GLISDAQCDD SMRAMKSQLY SCY
Length:343
Mass (Da):38,836
Last modified:September 27, 2005 - v3
Checksum:i67D38F0799FD81B2
GO
Isoform 2 (identifier: Q9D3D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-168: DRWIPSNYPITENIRAVYL → GWLPHSDKSSSHSERTSDI
     169-343: Missing.

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):19,266
Checksum:i262C63461FB90BE1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A5I7A2A5I7_MOUSE
Alpha-tocopherol transfer protein-l...
Ttpal
195Annotation score:
A6PW50A6PW50_MOUSE
Alpha-tocopherol transfer protein-l...
Ttpal
21Annotation score:

Sequence cautioni

The sequence BAC28381 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC30352 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC31654 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38289 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006032150 – 168DRWIP…RAVYL → GWLPHSDKSSSHSERTSDI in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_006033169 – 343Missing in isoform 2. 1 PublicationAdd BLAST175

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018052 mRNA No translation available.
AK033600 mRNA Translation: BAC28381.1 Different initiation.
AK039450 mRNA Translation: BAC30352.1 Different initiation.
AK043791 mRNA Translation: BAC31654.1 Different initiation.
AK081680 mRNA Translation: BAC38289.1 Different initiation.
AK156641 mRNA Translation: BAE33788.1
AL591488 Genomic DNA No translation available.
BC052389 mRNA Translation: AAH52389.3
CCDSiCCDS38317.1 [Q9D3D0-1]
RefSeqiNP_001292732.1, NM_001305803.1
NP_083788.2, NM_029512.2 [Q9D3D0-1]
NP_859423.2, NM_181734.3 [Q9D3D0-1]
XP_006500424.1, XM_006500361.1 [Q9D3D0-1]
XP_006500425.1, XM_006500362.1 [Q9D3D0-1]
UniGeneiMm.89828

Genome annotation databases

EnsembliENSMUST00000109405; ENSMUSP00000105032; ENSMUSG00000017679 [Q9D3D0-2]
ENSMUST00000109408; ENSMUSP00000105035; ENSMUSG00000017679 [Q9D3D0-1]
ENSMUST00000171696; ENSMUSP00000128922; ENSMUSG00000017679 [Q9D3D0-1]
GeneIDi76080
KEGGimmu:76080
UCSCiuc008ntc.1 mouse [Q9D3D0-1]
uc008ntf.1 mouse [Q9D3D0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018052 mRNA No translation available.
AK033600 mRNA Translation: BAC28381.1 Different initiation.
AK039450 mRNA Translation: BAC30352.1 Different initiation.
AK043791 mRNA Translation: BAC31654.1 Different initiation.
AK081680 mRNA Translation: BAC38289.1 Different initiation.
AK156641 mRNA Translation: BAE33788.1
AL591488 Genomic DNA No translation available.
BC052389 mRNA Translation: AAH52389.3
CCDSiCCDS38317.1 [Q9D3D0-1]
RefSeqiNP_001292732.1, NM_001305803.1
NP_083788.2, NM_029512.2 [Q9D3D0-1]
NP_859423.2, NM_181734.3 [Q9D3D0-1]
XP_006500424.1, XM_006500361.1 [Q9D3D0-1]
XP_006500425.1, XM_006500362.1 [Q9D3D0-1]
UniGeneiMm.89828

3D structure databases

ProteinModelPortaliQ9D3D0
SMRiQ9D3D0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105035

PTM databases

iPTMnetiQ9D3D0
PhosphoSitePlusiQ9D3D0
SwissPalmiQ9D3D0

Proteomic databases

EPDiQ9D3D0
PaxDbiQ9D3D0
PeptideAtlasiQ9D3D0
PRIDEiQ9D3D0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109405; ENSMUSP00000105032; ENSMUSG00000017679 [Q9D3D0-2]
ENSMUST00000109408; ENSMUSP00000105035; ENSMUSG00000017679 [Q9D3D0-1]
ENSMUST00000171696; ENSMUSP00000128922; ENSMUSG00000017679 [Q9D3D0-1]
GeneIDi76080
KEGGimmu:76080
UCSCiuc008ntc.1 mouse [Q9D3D0-1]
uc008ntf.1 mouse [Q9D3D0-2]

Organism-specific databases

CTDi79183
MGIiMGI:1923330 Ttpal

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074253
HOGENOMiHOG000293421
HOVERGENiHBG101124
InParanoidiQ9D3D0
OMAiQCDDSMR
OrthoDBiEOG091G0KN0
PhylomeDBiQ9D3D0

Miscellaneous databases

PROiPR:Q9D3D0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017679 Expressed in 227 organ(s), highest expression level in ear
ExpressionAtlasiQ9D3D0 baseline and differential
GenevisibleiQ9D3D0 MM

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTPAL_MOUSE
AccessioniPrimary (citable) accession number: Q9D3D0
Secondary accession number(s): A6PW51, Q3U0R3, Q7TS94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: September 27, 2005
Last modified: September 12, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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