UniProtKB - Q9D358 (PPAC_MOUSE)
Low molecular weight phosphotyrosine protein phosphatase
Acp1
Functioni
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.
By similarityCatalytic activityi
- EC:3.1.3.48By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:3.1.3.2By similarityThis reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 13 | NucleophileBy similarity | 1 | |
Active sitei | 19 | By similarity | 1 | |
Active sitei | 130 | Proton donorBy similarity | 1 |
GO - Molecular functioni
- acid phosphatase activity Source: MGI
- non-membrane spanning protein tyrosine phosphatase activity Source: InterPro
- phosphatase activity Source: MGI
- protein tyrosine phosphatase activity Source: UniProtKB
- SH3 domain binding Source: MGI
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Acp1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:87881, Acp1 |
VEuPathDBi | HostDB:ENSMUSG00000044573 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: MGI
Plasma Membrane
- cytoplasmic side of plasma membrane Source: MGI
- sarcolemma Source: MGI
Other locations
- cytoplasm Source: MGI
- neuron projection Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000046559 | 2 – 158 | Low molecular weight phosphotyrosine protein phosphataseAdd BLAST | 157 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 132 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 133 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3861 |
EPDi | Q9D358 |
jPOSTi | Q9D358 |
MaxQBi | Q9D358 |
PeptideAtlasi | Q9D358 |
PRIDEi | Q9D358 |
ProteomicsDBi | 291644 [Q9D358-1] 291645 [Q9D358-2] |
2D gel databases
REPRODUCTION-2DPAGEi | Q9D358 |
PTM databases
iPTMneti | Q9D358 |
PhosphoSitePlusi | Q9D358 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000044573, Expressed in liver and 213 other tissues |
ExpressionAtlasi | Q9D358, baseline and differential |
Genevisiblei | Q9D358, MM |
Interactioni
Subunit structurei
Interacts with EPHA2; dephosphorylates EPHA2.
Interacts with EPHB1.
By similarityInteracts with the SH3 domain of SPTAN1. There is no interaction observed for isoform 2.
By similarityGO - Molecular functioni
- SH3 domain binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 197927, 8 interactors |
IntActi | Q9D358, 2 interactors |
STRINGi | 10090.ENSMUSP00000106509 |
Chemistry databases
BindingDBi | Q9D358 |
Miscellaneous databases
RNActi | Q9D358, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9D358 |
SMRi | Q9D358 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3217, Eukaryota |
GeneTreei | ENSGT00940000158351 |
HOGENOMi | CLU_071415_2_0_1 |
InParanoidi | Q9D358 |
OrthoDBi | 1362234at2759 |
PhylomeDBi | Q9D358 |
TreeFami | TF353727 |
Family and domain databases
InterProi | View protein in InterPro IPR023485, Ptyr_pPase IPR036196, Ptyr_pPase_sf IPR002115, Tyr_Pase_low_mol_wt_mml IPR017867, Tyr_phospatase_low_mol_wt |
Pfami | View protein in Pfam PF01451, LMWPc, 1 hit |
PRINTSi | PR00719, LMWPTPASE PR00720, MAMMALPTPASE |
SMARTi | View protein in SMART SM00226, LMWPc, 1 hit |
SUPFAMi | SSF52788, SSF52788, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEVGSKSVL FVCLGNICRS PIAEAVFRKL VTDEKVSDNW RIDSAATSTY
60 70 80 90 100
EVGNPPDYRG QNCMRKHGIH MQHIARQITK EDFATFDYIL CMDESNLRDL
110 120 130 140 150
NRKSNQVKNC KAKIELLGSY DPQKQLIIED PYYGNDSDFE VVYQQCLRCC
KAFLEKTY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ561M1 | Q561M1_MOUSE | Low molecular weight phosphotyrosin... | Acp1 | 158 | Annotation score: | ||
A0A1W2P7X3 | A0A1W2P7X3_MOUSE | Acid phosphatase | Acp1 | 114 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural varianti | 14 | L → P1 Publication | 1 | ||
Natural varianti | 157 | T → P1 Publication | 1 | ||
Isoform 21 Publication (identifier: Q9D358-2) | |||||
Natural varianti | 67 | R → HCurated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050726 | 41 – 74 | RIDSA…HMQHI → AIDSSAVSDWNVGRPPDPRA VSCLRNRGISTAHK in isoform 2. 3 PublicationsAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y17343 mRNA Translation: CAA76753.1 Y17344 mRNA Translation: CAA76754.1 Y17345 mRNA Translation: CAA76755.1 AK014603 mRNA Translation: BAB29458.1 AK018329 mRNA Translation: BAB31164.1 AK019186 mRNA Translation: BAB31593.1 AK082955 mRNA Translation: BAC38707.1 BC039744 mRNA Translation: AAH39744.1 |
CCDSi | CCDS36427.1 [Q9D358-1] CCDS49045.1 [Q9D358-2] |
RefSeqi | NP_001103709.1, NM_001110239.1 NP_067305.2, NM_021330.4 [Q9D358-1] |
Genome annotation databases
Ensembli | ENSMUST00000062740; ENSMUSP00000106509; ENSMUSG00000044573 [Q9D358-1] |
GeneIDi | 11431 |
KEGGi | mmu:11431 |
UCSCi | uc007ngw.2, mouse [Q9D358-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y17343 mRNA Translation: CAA76753.1 Y17344 mRNA Translation: CAA76754.1 Y17345 mRNA Translation: CAA76755.1 AK014603 mRNA Translation: BAB29458.1 AK018329 mRNA Translation: BAB31164.1 AK019186 mRNA Translation: BAB31593.1 AK082955 mRNA Translation: BAC38707.1 BC039744 mRNA Translation: AAH39744.1 |
CCDSi | CCDS36427.1 [Q9D358-1] CCDS49045.1 [Q9D358-2] |
RefSeqi | NP_001103709.1, NM_001110239.1 NP_067305.2, NM_021330.4 [Q9D358-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2P4U | X-ray | 1.90 | A/B/C/D | 2-158 | [»] | |
5JNU | X-ray | 2.54 | A/B | 1-158 | [»] | |
AlphaFoldDBi | Q9D358 | |||||
SMRi | Q9D358 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 197927, 8 interactors |
IntActi | Q9D358, 2 interactors |
STRINGi | 10090.ENSMUSP00000106509 |
Chemistry databases
BindingDBi | Q9D358 |
ChEMBLi | CHEMBL3593153 |
PTM databases
iPTMneti | Q9D358 |
PhosphoSitePlusi | Q9D358 |
2D gel databases
REPRODUCTION-2DPAGEi | Q9D358 |
Proteomic databases
CPTACi | non-CPTAC-3861 |
EPDi | Q9D358 |
jPOSTi | Q9D358 |
MaxQBi | Q9D358 |
PeptideAtlasi | Q9D358 |
PRIDEi | Q9D358 |
ProteomicsDBi | 291644 [Q9D358-1] 291645 [Q9D358-2] |
Protocols and materials databases
DNASUi | 11431 |
Genome annotation databases
Ensembli | ENSMUST00000062740; ENSMUSP00000106509; ENSMUSG00000044573 [Q9D358-1] |
GeneIDi | 11431 |
KEGGi | mmu:11431 |
UCSCi | uc007ngw.2, mouse [Q9D358-1] |
Organism-specific databases
CTDi | 52 |
MGIi | MGI:87881, Acp1 |
VEuPathDBi | HostDB:ENSMUSG00000044573 |
Phylogenomic databases
eggNOGi | KOG3217, Eukaryota |
GeneTreei | ENSGT00940000158351 |
HOGENOMi | CLU_071415_2_0_1 |
InParanoidi | Q9D358 |
OrthoDBi | 1362234at2759 |
PhylomeDBi | Q9D358 |
TreeFami | TF353727 |
Miscellaneous databases
BioGRID-ORCSi | 11431, 4 hits in 74 CRISPR screens |
ChiTaRSi | Acp1, mouse |
PROi | PR:Q9D358 |
RNActi | Q9D358, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000044573, Expressed in liver and 213 other tissues |
ExpressionAtlasi | Q9D358, baseline and differential |
Genevisiblei | Q9D358, MM |
Family and domain databases
InterProi | View protein in InterPro IPR023485, Ptyr_pPase IPR036196, Ptyr_pPase_sf IPR002115, Tyr_Pase_low_mol_wt_mml IPR017867, Tyr_phospatase_low_mol_wt |
Pfami | View protein in Pfam PF01451, LMWPc, 1 hit |
PRINTSi | PR00719, LMWPTPASE PR00720, MAMMALPTPASE |
SMARTi | View protein in SMART SM00226, LMWPc, 1 hit |
SUPFAMi | SSF52788, SSF52788, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PPAC_MOUSE | |
Accessioni | Q9D358Primary (citable) accession number: Q9D358 Secondary accession number(s): O88739, O88740, Q9QWF5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 162 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families